대한미생물학회지 (The Journal of the Korean Society for Microbiology)

대한미생물학회 (The Korea Society for Microbiology)
권호 표지

Orientia tsutsugamushi 감염에 의한 사람 제대정맥 내피세포에서 부착분자 발현의 변화

Increased Expression of Adhesion Molecules on Human Umbilical Vein Endothelial Cells by Orientia tsutsugamushi Infection

  • 이은봉 (서울대학교 의과대학 미생물학교실) ;
  • 한승훈 (서울대학교 의과대학 미생물학교실) ;
  • 김상욱 (서울대학교 의과대학 미생물학교실) ;
  • 인경수 (서울대학교 의과대학 미생물학교실) ;
  • 성승용 (서울대학교 의과대학 미생물학교실) ;
  • 김익상 (서울대학교 의과대학 미생물학교실) ;
  • 최명식 (서울대학교 의과대학 미생물학교실)
  • Lee, Eun-Bong (Department of Microbiology, Seoul National University College of Medicine) ;
  • Han, Seung-Hoon (Department of Microbiology, Seoul National University College of Medicine) ;
  • Kim, Sang-Wook (Department of Microbiology, Seoul National University College of Medicine) ;
  • Ihn, Kyung-Soo (Department of Microbiology, Seoul National University College of Medicine) ;
  • Seong, Seung-Yong (Department of Microbiology, Seoul National University College of Medicine) ;
  • Kim, Ik-Sang (Department of Microbiology, Seoul National University College of Medicine) ;
  • Choi, Myung-Sik (Department of Microbiology, Seoul National University College of Medicine)
  • 발행 : 2000.04.30
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초록

Scrub typhus is caused by Orientia tsutsugamushi characterized by fever, headache, lymphadenopathy and eschar formation. Infiltration of inflammatory cells around blood vessels and within the affected organs isS known to be pathologic hallmark of the scrub typhus. Recently, expression of adhesion molecules on vascular endothelial cells was implicated as an important pathogenic mechanism in rickettsial disease. This study was performed to examine the expression of adhesion molecules and to investigate its role in the pathogenesis of O. tsutsugamushi infection. The expression of adhesion molecules on human umbilical vein endothelial cells (HUVEC) was measured by flow cytometry and indirect immunofluorescence. Expression of E-selectin, ICAM-1 and VCAM-1 was significantly increased 4 hours after the infection and persisted at least for 24 hours. Expression of those molecules was not induced by killed O. tsutsugamushi. Adhesion of polymorphonuclear cells and mononuclear cells to HUVEC was increased after the infection with O. tsutsugamushi. In conclusion, adhesion molecules are expressed on HUVEC during the infection of live O. tsutsugamushi and those molecules can contribute to the infiltration of inflammatory cells during the infection.

키워드

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