The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Effect of SAENGMAEGSAN extract on the Cardiovascular System and Regional Cerebral Blood Flow

생맥산(生脈散)이 심혈관계(心血管系) 및 국소뇌혈류량(局所腦血流量)에 미치는 영향(影響)

  • Shin, Dae-Chul (Dept. of Oriental Medicine, Graduate School, Dong Eui University) ;
  • Kim, Young-Kyun (Dept. of Oriental Medicine, Graduate School, Dong Eui University)
  • 신대철 (동의대학교 한의과대학 심계내과학교실) ;
  • 김영균 (동의대학교 한의과대학 심계내과학교실)
  • Published : 1999.09.29
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Abstract

SAENGMAEGSAN(SMS) has been used in oriental medicine for many years as a therapeutic agent for cerebral disease. The effect of SMS on the vascular system is not known. The purpose of this study was to determine the effect of SMS on blood pressure, regio-nal cerebral blood flow(rCBF). 1. Blood pressure did not change by SMS in rats. 2. rCBF was increased by SMS in a dose-dependent manner. 3. Pretreatment with propranolol. methylene blue and indomethacin significantly inhibited SMS induced increase in rCBF. These results suggest that SMS causes a diverse response of blood pressure, regional cerebral blood flow (rCBF) and pial arterial diameter. The increase in rCBF is also mediated by prostaglandins. cyclic GMP and adrenergic ${\beta}$receptor.

Keywords

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