The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
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Nitric Oxide Generation from Peritoneal Macrophages by Salvia miltiorrhiza Root Water Extract

단삼(丹蔘) 수침액에 의한 복강대식세포로부터 산화질소의 발생

  • Jo, Hyun-Ju (Department of Digestive Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon, Seok-Jae (Department of Digestive Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • 조현주 (원광대학교 한의과대학 소화기내과학교실) ;
  • 문석재 (원광대학교 한의과대학 소화기내과학교실)
  • Published : 1999.09.29
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Abstract

Dansam, the root of Salvia miltiorrhiza Bge, (Labiatae), has a bitter taste and a slightly 'cold' property, and is nontoxic. In the present study, effect of Dansam on nitric oxide (NO) generation from peritoneal macrophags was examined. Dansam had no effect on NO generation by itself, whereas recombinant interferon-${\gamma}\;(rIFN-{\gamma})$ alone had modest activity. When Dansam was used in combination with $rIFN-{\gamma}$, there was a marked cooperative induction of NO generation in a dose-dependent manner, The optimal effect of Dansam on NO generation was shown at 6 hr after treatment with $rIFN-{\gamma}$. Furthermore, the effect of Dansam was mainly dependent on Dansam-induced tumor necrosis $factor-{\alpha}\;(TNF-{\alpha})$ secretion. These results suggest that Dansam induces NO generation from macrophages by the result of Dansam-induced $TNF-{\alpha}$ secretion.

Keywords

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