The Journal of Internal Korean Medicine (대한한방내과학회지)

The Society of Internal Korean Medicine (대한한방내과학회)
권호 표지

Effects of Scolopendrae corpus on turmor promotion in two-stage carcinogenesis in mice

오공(蜈蚣)이 마우스에서 2단계(段階) 발암화(發癌化) 과정(過程)에 미치는 영향(影響)

  • Kim, Kil-Sub (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Hwang, Young-Guen (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Yoon, Cheol-Ho (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Seo, Un-Kyo (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Jong-Dae (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Jeong, Ji-Cheon (Dept. of Internal Medicine, College of Oriental Medicine, Dongguk University) ;
  • Nam, Kyung-Soo (Dept. of Pharmacology, College of Medicine, Dongguk University) ;
  • Kang, Jeong-Jun (Dept. of Internal Medicine, Hospital of Oriental Medicine, Hanseo University)
  • 김길섭 (동국대학교 한의과대학 내과학교실) ;
  • 황영근 (동국대학교 한의과대학 내과학교실) ;
  • 윤철호 (동국대학교 한의과대학 내과학교실) ;
  • 서운교 (동국대학교 한의과대학 내과학교실) ;
  • 김종대 (동국대학교 한의과대학 내과학교실) ;
  • 정지천 (동국대학교 한의과대학 내과학교실) ;
  • 남경수 (동국대학교 의과대학 약리학교실) ;
  • 강정준 (한서대학 한방병원 내과)
  • Published : 1999.09.29
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Abstract

To clarifiy the effects of Scolopendrae corpus(S-C) on turmor promotion in two-stage carcinogenesis in mice was investigated. In vivo system, S-C were seen to gave an inhibitory activity on TPA-induced mouse ear edema. In addition, the S-C were proved to have antitumor-promoting activity in two-stage mouse skin carcinogenesis induced by DMBA and two-stage mouse lung carcinogenesis induced by 4-NQO as a initiator plus TPA and glycerol as a promoter. Moreover, S-C significantly exhibited an cytolytic effect in $HepG_2$ cells and showed significant antitumor activity against Sarcoma-180 bearing mice by oral administration. These results suggest that S-C could be effective in adjuvant chemotherapy for human cancer.

Keywords

References

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