The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Uncaria Rhynchophylla on Vestibular Compensation in Unilateral Labyrinthectomized Rats

조구등(釣鉤藤)이 일측(一側) 전정기관(前庭器官) 손상(損像) 흰쥐의 전정보상(前庭補償)에 미치는 영향(影響)

  • Song, Jin-Ho (Department of Physiology, School of Medicine & MRRC, Wonkwang University) ;
  • Lee, Sung-Ho (Department of Physical Education, College of Education, Wonkwang University) ;
  • Kim, Min-Sun (Department of Physiology, School of Medicine & MRRC, Wonkwang University) ;
  • Sohn, In-Chul (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University) ;
  • Park, Byung-Rim (Department of Physiology, School of Medicine & MRRC, Wonkwang University) ;
  • Kim, Jae-Hyo (Department of Acupuncture & Moxibustion, College of Oriental Medicine, Wonkwang University)
  • 송진호 (원광대학교 의과대학 생리학교실 & 의약자원연구센터) ;
  • 이성호 (원광대학교 사범대학교 체육교육과) ;
  • 김민선 (원광대학교 의과대학 생리학교실 & 의약자원연구센터) ;
  • 손인철 (원광대학교 한의과대학 경혈학교실) ;
  • 박병림 (원광대학교 의과대학 생리학교실 & 의약자원연구센터) ;
  • 김재효 (원광대학교 한의과대학 경혈학교실)
  • Published : 1999.09.30
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Abstract

The purpose of this study was to asses the etlect of Uncaria rhynchophylla (UR). one of the oriental herbs having a capability to block calcium channels, on affecting vestibular compensation (VC) in Sprague - Dawley rats. Animals were divided into a drug treatment group receiving, UR per oral for 10 days preceding unilateral labyrinthectomy (ULX) and a control group with saline ingestion, To evaluate behavioral changes. horizontal spontaneous nystagmus (SN) and roll head tilt (RHT) were recorded by a video camem with zoom lens in the course of vestibular compensation (VC). Immunohistochemical staining was performed by conventional ABC method to visualize cFos-like immunoreactive (cFLI) neurons in the medial vestibular nuclei (MVN) and cFLI cells were counted by image analyzer. Bodyweight was increased significantly, about 35g, by UR treatment for 10 clays before ULX. Compared with the control group, the drug group showed significant reduction of RHT 6 hrs after ULX as well as fast disappearance of SN at early stages of vestibular compensation. Also, recovery of the spatial and temporal cFLI expressions in the bilateral MVN was accelerated 24 hrs after ULX. These results suggest that Uncaria rhynchophyila has a beneficial effect to ameliorate vestibular compensation in unilateral labryinthectomized rats.

Keywords

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