Journal of Korean Society of Occupational and Environmental Hygiene (한국산업보건학회지)

Korean Industrial Hygiene Association (한국산업보건학회)
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Study on the Acute and Sub-Acute Inhalation Toxicity of 1-Bromopropane in SD Rats

Rat를 이용 1-Bromopropane의 급성 및 아급성 흡입독성 연구

  • Kim, Hyeon-Yeong (Industrial Chemicals Research Center, Industrial Health Research Institute, Korea Industrial Safety Corporation) ;
  • Jeong, Jae-Hwang (Industrial Chemicals Research Center, Industrial Health Research Institute, Korea Industrial Safety Corporation) ;
  • Chung, Yong-Hyun (Industrial Chemicals Research Center, Industrial Health Research Institute, Korea Industrial Safety Corporation) ;
  • Lee, Yong-Muk (Industrial Chemicals Research Center, Industrial Health Research Institute, Korea Industrial Safety Corporation) ;
  • Sur, Gil-Soo (Department of Chemical Engineering, Yeungnam University)
  • 김현영 (한국산업안전공단 산업보건연구원) ;
  • 정재황 (한국산업안전공단 산업보건연구원) ;
  • 정용현 (한국산업안전공단 산업보건연구원) ;
  • 이용묵 (한국산업안전공단 산업보건연구원) ;
  • 서길수 (영남대학교 공과대학 화학공학과)
  • Published : 1998.11.13
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Abstract

The purpose of this study was to investigate the acute(4 hrs) and repeated-dose(6 hrs a day, 5 days a week, 8 weeks) toxic effects of 1-bromopropane(1-BP) on Sprague-Dawley (SD) rats which were treated by inhalation. The results were as follows ; 1. The median lethal concentration($LC_{50}$) was estimated 14,374 ppm(confidence limit 95% ; 13,624~15,596 ppm) in acute inhalation. Abnormal clinical signs related to the 1-BP were not observed with the acute inhalation dose. Gross findings of necropsy revealed no evidence of specific toxicity related to the 1-BP. 2. By sub-acute inhalation the body weights of male and female were significantly reduced(p<0.001) by the dose of 1,800 ppm compared with control group, while the relative weights of liver were significantly increased(p<0.001) in both sexes. However there were no significant variation in food consumption, urine biochemistry, hematology and blood biochemistry for the exposed rats compared with the control rats. Abnormal clinical signs and gross findings of necropsy related to the 1-BP were not shown. No toxicologic lesions were observed by the histopathological test.

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