Post-Antibiotic Effect of DW-116, a New Quinoloen

새로운 퀴놀론 항균제 DW-116의 Post-Antibiotic Effect

  • Published : 1998.04.01

Abstract

The post-antibiotic effects (PAE) of DW-116 were evaluated against Bacillus subtilis ATCC 6633, Bacillus cereus ATCC 27348, Staphylococcus aureus ATCC 25923 , Escherichia coli ATCC 25922 and Pseudomonas aeruginosa MB4-16, repectively. Against gram-positive bacteria, PAEs of DW-116 were longer duration (20-35 min) than those of rufloxacin(1O-20 min), and shorter than those of ciprofloxacin (50-90 min). Especially, against E. coli, DW-116 and ciprofloxacin obtained approximately 3 hrs of PAES.

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References

  1. Quinolone antimicrobiol agents(2nd edn.) Invitro activity of the quinolones Eliopoulos, G.M.;Eliopoulos, C.T.;Hooper D.C.(ed.);Wolfson, J.S.(ed.)
  2. J. Antimicrob. Chemother v.39 In vitro and in vivo activities of DW-116, a new quinolone Choi, K.H.;Hong, K.S.;Kim, S.K.;Lee, D.K.;Yoon, S.J.;Choi, E.C.
  3. USA Patent no. 5496947-A. 6 Novel quinolone carboxylic acid derivatives Yoon, S.J.;Chung, Y.H.;Lee, C.W.;Oh, Y.S.;Choi, D.R.;Kim, N.D.
  4. Program and Abstracts of the 35th Interscience Conference on Antimicrobiol Agents and Chemotherapy The pharmacokinetic studies of DW-116. Lee, W.Y.;Hwang, Y.H.;Sung, S.K.;Moon, E.Y.;Chung, S.J.;Lee. D.K.
  5. J. Antimicrob. Chemother. v.32 The post-antibiotic effect Mackenzie, F.M.;Gould, I.M.
  6. Antimicrob. Agents Chemother. v.35 Impact of pH and cation supplement on in vitro post-antibiotic effect Gudmunsson, A.;Erlendsdottir, H.;Gottfredsson, M.;Gudmunsson, S.
  7. National Committee for Clinical Laboratory Standards Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria thar Grow Aerobically-third edition: approved standard M7-A3 NCCLS
  8. Chemotherapy v.40 Post-antibiotic effects of cefdnir on E. Coli, K. pneumoniae, S. aurues and S. pyogenes Howard, B.M.A.;Pinney, R.J.;Smith, J.T.
  9. Antimicrob. Agents Chemother v.32 Comparison of two methods for determining in vitro post-antibiotic effects of three antibiotics on E. coli. Rescotte, D.L.;Nix, D.E.;Holden, P.;Schentag, J.J.
  10. Yakhak Hoeji v.40 Post-antibiotic effect of LB 20304, a new quinolone antibiotic Ahn, M.J.;Paek, K.S.;Kim, M.Y.;Kim, I.C.;Kwak, J.H.