YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Herbal Medicine on Tibia Bone Changes in Ovariectomized Rats and SAM P6 Mice

한약이 난소제거 흰쥐와 SAM P6 생쥐의 골소주에 미치는 영향

  • Published : 1998.04.01
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Abstract

The effects of herbal medicine on travecular bone area were studied using ovariectomized rat as an animal model of Type I osteoporosis and SAM P6 as that of Type II. We counted red blood cells(RBC), hemoglobin(Hb), and hematocrit(Hct) using Couter`sR method. Each traditional boiling water extract of Achyrathis Radix, Psoraleae Fructus, Rehmanniae Radix Preparat, and Cornii Fructus and a systemic water extract of Astragali Ractiex was given 5g/kg/day, p.o., for 30 days in a group of 4-5 ovariectormized rats. One ml of blood was taken by tail vein at day 0, 7, 14, 21, and 30 days after administration of the extract. The traditional hot water extract of Cervi parvumn Corni (Cervi) was given the same dose as described above for 14 days in a group of 10 SAM P6 mice and systemic water extract of Astragali Radix was administered as the same dose as above for 30 days in 10 SAM P6 mice. Travecular bone area was measured 5 mcm decalcified and stained thin bone slice by image analysis using a digitalizer. In Type I, ovariectomized rats, administration of Astragali Radix, Rhemanniae Radix Preparat, and Corni Fructus decreased in RBC, Hb and Hct. In Type II, administration of Cervi increased in RBC and Hct and that of Astragali Radix was also elevated RBC. In Type I, any administration of herbal medicine used in this study did not elevate travecular bone area significantly except Corni Fructus showed a trend of increase in travecular bone area. However, Type II, Cervi and Astragali Radix increased in both mean and total travecular bone area. Thus, there are significant difference in response of herbal medicine in different types of osteoporosis.

Keywords

References

  1. J. Bone Joint Surg. v.56 The mechanical properties of cortical bone Reilly, D.T.;Burstein, A.H.
  2. Lancet v.341 Pathogeneiss of osteoporosis Dempster, D.W.;Lindsay, R.
  3. Seminars Arthr. Rheum v.20 no.4 Osteoporosis associated with rheumatoid arthritis:pathogenesis and management Joffe, I.;Epstein, S.
  4. Science v.142 Measurement of bone minerla in vivo.: An improved method. Cameron, J.R.;Sorenson, J.
  5. Histopathologic Technic and Practical Histochemistry(4th ed.) Lillie, R.D.;Fuller, H.M.
  6. J. Int. Med. v.232 The bone mineral density in acquired growth hormone deficiency correlates with circulating levels of insulin-like growth factor Ⅰ Johansson, A.G.;Burman, P.;Westermark, K.;Ljunghall, S.
  7. J. Am. Geriatrics Soc. v.41 Low curculatinf level of Insulin-like growth factors and testosterone in chronically instutytuinalized elderly men Abbasi, A.A.;Drinka, P.J.;Mattson, D.E.;Rudman, D.
  8. J. Clin. Endocrinol. Metab. v.67 Effect of excess endogenous androgens on bone density in young women Buchanan, J.R.;Hospodar, P.;Myers, C.;Leuenberger, P.;Demers, L.M.
  9. Am. J. Obstet. Gynecol. v.156 Controversies concerning the safety of estrogen replacement therapy Whitehead, M.I.;Fraser, D.
  10. Metabolic bone disease Bone metabolisim and calcium regulation Raisz, L.G.;Avioli, L.V.(ed.);Krane, S.M.(ed.)
  11. N. Engl. J. Med. v.328 Effect of calcium supplementation of bone lass in postmenopausal women Reid, I.R.;Ames, R.W.;Evans, M.C.;Gamble, G.D.;Sharpe, S.J.
  12. J. Bone Miner. Res. v.3 Fluoride content in human iliac boneL Results in controls, patients with fluorosis, and osteoporotic patients treated with fluoride Boivin, G.;Chapuy, M.C.;Baud, C.A.;Meunier, P.J.
  13. Life Sci. v.38 Effect of Ipriflavone on Flucocorticoid-induced osteoporosis in rats Yamazaki, I.;Shino, A.;Shimizu, Y.;Tsukuda, R.;Shirakawa, Y.;Kinoshita, M.
  14. N. Engl. J. Med. v.328 Prevention of corticosteroid osteoporosis: A comparison of calcium, calcitriol, and calcitonin Sambrook, P.;Birmingham, J.;Kelly, P.;Kempler, S.;Nguyen, T.;Pocock, N.;Eisman, J.
  15. N. Engl. J. Med. v.326 Treatment of postmenopausal osteoporosis with calcitriol or calcium Tilyard, M.W.;Spears, G.F.;Thomson, J.;Dovey, S.
  16. J. Clin. Invest. Bone turnover in postmenopausal osterporosis: Effect of calcitonin treatment Civitelli, R.;Gonnelli, S.;Zacchei, F.;Bigazzi, S.;Vattimo, A.;Avioli, L.V.;Gennari, C.
  17. 제 46회 대한약학회학술대회 초록집 Studies on osteoporosis using traditional herbal medicine 김연태;김진숙;이한구;김정숙;송계용
  18. 응용약물학회 v.5 한약에 의한 SAM P6와 SAM R1의 생리적인 변화 김정숙;김연태;이제현;하혜경;전원경;한상섭
  19. in The SAM model of senescence Takeda, T.;Hosokawa, M.;Higuichi, K.
  20. in the SAM model of senescence Osteoporotic bone chamges in SMA P6 are dur to a decrease in osteoblast progenitor cells Suda, T.;Miyama, K.;Uchiyama, Y.;Katagiri, T.;Yamaguchi, A.;Sato, T.;Takeda, T.(ed.)
  21. Proc. Soc. Exper. Biol. Med. v.166 Effect of ovariectomy on circulating calcutonin levels in the rat Cressent, M.;Bouizar, A.;Moukhtar, M.S.;Milhaud, G.
  22. Calcified tissue internat v.47 Progressive cancellous bone loss in rats after a-drenalectomy and oophorectomy Durbridge, T.C.;Morris, H.A.;Parsons, A.M.;Parkinson, I.H.;Moore, R.J.;Porter, S.;Need, A.G.;Nordin, B.E.;Vernon-Roberts, B.
  23. J. Clin. Endocrinol. Metab. v.71 A potential primate model for bone loss resulting from medical oophorectomy of menopause Mann, D.R.;Gould, K.G.;Collins, D.C.
  24. Fundamentals of Biostatistics Rosner, B.
  25. J. Clin. Endocrinol. Metab. v.69 Osteocalcin and deoxyribonucleic acid synthesis in vitro and histomorphometric indices of bone formation in postmenopausal osteoporosis Marie, P.J.;Sabbagh, a.;Vernejoul, M.C.;Lomri, A.
  26. Metabolic Bone Disease: in Harrisons's Principles of Internal Medicine v.2 Krane, S.M.;Holick, M.F.
  27. 생약학회지 v.27 no.4 노화촉진생쥐에서 녹용의 조혈작용에 관한 연구 김연태;김정숙
  28. 본초학 강병수;고운채;김선희;노승현;서영배;송호준;신민교;안덕균;이상인;이영종;이강희;주영승
  29. 한국한의학연구소논문집 v.1 no.1 녹용의 물추출액 두여가 난소를 절제한 흰쥐의 여성호르몬 변화에 미치는 영향 김미려;양제하;권용준
  30. 중약약리여응용 왕유생
  31. 생약학회지 v.27 no.4 황기뿌리의 성분연구(Ⅰ) 김진숙;김연태;김정숙
  32. The laboratory rat. (Vol. Ⅱ) Baker, H.J.;Lindsey, J.R.;Weisbroth, S.H.
  33. 實驗動物學 田嶋嘉雄前