Journal of Pharmaceutical Investigation
- Volume 28 Issue 1
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- Pages.7-13
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- 1998
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
The Preparation of Controlled-Release Microcapsules for Captopril and Their Dissolution Characteristics
제어 방출협 캅토프릴 마이크로캅셀의 제조 및 용출 특성
- Choi, Hyun-Soon (College of Pharmacy, Chungnam National University) ;
- Ge, Jiang (College of Pharmacy, Chungnam National University) ;
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Lee, Gye-Won
(College of Pharmacy, Chungnam National University) ;
- Jee, Ung-Kil (College of Pharmacy, Chungnam National University)
- Published : 1998.03.20
Abstract
The captopril microcapsules were prepared and were investigated by measuring their size distribution using Scanning Electron Microscopy(SEM) and dissolution of captopril. Cetyl alcohol microcapsules prepared by emulsion melted-cooled method with various ratios of drug to cetyl alcohol were spherical and uniform. The release rate of cetyl alcohol microcapsules was decreased proportionally as the content of cetyl alcohol increased but, the particle size of microcapsules was increased. The surface of cetyl alcohol microcapsules was comparatively rough as drug content increased. Pellet type microcapsules were prepared using fluidized-bed coating system by spraying captopril solution on nonpareil-seeds followed by applying
Keywords
- Microcapsules;
- Emulsion melted-cooled method;
- Cetyl alcohol;
- Fluidized-bed coating system;
- $Eudragit{\circledR}$RS