Journal of Pharmaceutical Investigation

The Korean Society of Pharmaceutical Sciences and Technology (한국약제학회)
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The Effect of Synthetic Polymer Membranes on the Skin Permeation of Anti-AIDS Drugs

항에이즈 약물의 경피흡수에 미치는 합성고분자 멤브레인의 영향

  • Lee, Kyung-Jin (College of Pharmacy, Pusan National University) ;
  • Kim, Dae-Duk (College of Pharmacy, Pusan National University) ;
  • Chien, Yie W. (College of Pharmacy, Rutgers-The State University of New Jersey)
  • Published : 1998.03.20
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Abstract

The effect of synthetic polymer membranes on the permeation rate of dideoxynucleoside-type anti-HIV drugs through hairless rat skin was studied using ethylene/vinyl acetate copolymer (EVA) and ethylene/methyl acrylate copolymer (EMA) membranes fabricated by solvent casting method. In vitro skin permeation kinetics study of DDC (2',3'-dideoxythymidine), DDI (2',3'-dideoxyinosine) and AZT (3'-azido-3'-deoxythymidine) across the (membrane/skin) composite was conducted for 24 hours at $37^{\circ}C$ using the Valia-Chien skin permeation system. The results showed that skin permeation rate of each drug across the (skin/membrane) composite was mainly dependent on the property of the membrane. Proper selection of the polymeric membrane which resembles hydrophilicity/lipophilicity of the delivering drug was important in controlling the skin permeation rate.

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