YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Preparation of Cefaclor-Containing Gelatin Microcapsules and Their Drug Release Characteristics

수용성 약물인 세파클러를 함유하는 젤라틴 마이크로캅셀의 제조 및 약물 방출특성

  • Published : 1997.02.01
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Abstract

In order to formulate a controlled release system for oral drug delivery, the microcapsules were prepared in w/o emulsion containing cefaclor as a water-soluble model drug by th e method of interfacial polycondensation. Gelatin wis selected as a suitable polymer for interfacial polycondensation. Gelatin solution containing drug was emulsified in an organic phase under mechanical stirring. After emulsification, terephthaloyl chloride was added as cross linking agent, followed by mechanical stirring, washing and drying. Physical characteristics of microcapsules were investigated by optical microscopy, scanning electron microscopy and particle size analysis. Mean particle sizes of gelatin microcapsules were, in the range, of about 20~50 ${\mu}$m. The microcapsules were in good apperance with spherical shapes before washing, but were destroyed partially after washing and drying, even though some microcapsules were still maintained in their shapes. Contents of cefaclor in the microcapsules were calculated by UV spectrophotometry after 3 days extraction with pH 4 carbonate buffer solution. The effects of cross linking time. pH. concentration of cross-linking agent, and temperature on drug release kinetics have been discussed extensively.

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References

  1. Novel Drug Delivery Systems(2nd ed) Fundamentals of Rate-controlled Drug Delivery Chien, Y. W.
  2. J. Antimicro. Chemother. v.26 The pharmacokinetics of the oral cephalosporins-a review Wise, R.
  3. Int. J. Antimicrobial Agents v.2 Cefaclor Wilson, R.
  4. J. Pharm. Dyn. v.7 Intestinal absorption mechanism of amino-β-lactam antibiotics. Ⅲ. Kinetics of carrier-mediated transport across the rat small intestine in situ Nakashima, E.;Tsuji, A.;Kagatani, S.;Yamana, T.
  5. Biochem. Pharmacol. v.33 Kinetics and mechanism of in vitro uptake of amino-β-lactam antibiotics by rat small intestine and relation to the intact-peptide transport system Nakashima, E.;Tsuji, A.;Mizuo, H.;Yamana, T.
  6. J. Pharm. Pharmacol. v.31 Saturable absorption of amino-cepalosporins by the rat instestine Ysuji, A.;Nakashima, E.;Asano, T.;Nakashima, R.;Yamana, T.
  7. J. Pharm. Sci. v.59 Luzzi, L. A.;Microencapsulation
  8. J. Pharm. Pharmacol. v.40 Preparation of biodegradable poly (±)lactide microparticles using a spray-drying technique. Bodmeier, R.;Chen, H.
  9. J. Microencapsulation v.8 Mixed-walled microcapsules made of cross-linked proteins and polysaccharides: Preparation and properties Levy, M. C.;Andry, M. C.
  10. J. Microencapsulation v.6 Preparation of nano- and microspheres by polycondensation techniques Arshady, R.
  11. Polymer Eng. & Sci. v.29 Microspheres and microcapsules: A survey of manufacturing techniques. Part 1. suspension cross-linking Arshady, R.
  12. The Theory and Practice of Industrial Pharmacy(3rd ed.) Microencapsulation Bakan, J. A.
  13. Handbook of Pharmaceutical Excipients(2nd ed.) Gelatin The American Pharmaceutical Association and the royal Pharmaceutical Society of Great Britain
  14. Biodegradable Hydrogels for Drug Delivery Drug release from hydrogels with biodegradable back bones Park, K.;Shalaby, W. S. W.;Park, H.
  15. J. Microencapsulation v.7 Controlled release of nifedipine from gelatin microspheres and microcapsules: in vitro kinetics and pharmacokinetics in man Leucuta, S. E.
  16. J. Pharm. Sci. v.65 Clofibrate microcapsules: Preparation and Release rate studies Madan, P. L.;Devendra, K.;price, J. C.
  17. Chem. Pharm. Bull. v.34 Studies on microcapsules. Ⅳ. Influence of properties of drugs on microencapsulation and dissolution behavior Koida, Y.;Kobayashi, M.;Samejima, M.
  18. J. Microencapsulation v.7 Encapsulation of water-soluble drugs by a modified solvent evaporation method. Ⅰ. Effect of process and formulation variables on drug entrapment. Alex, R.;Bodmeier, R.
  19. J. Controlled Release v.36 The effect of particle microstructure on the somatostatin release from poly(lactide) microspheres prepared by a w/o/w solvent evaporation method Herrmann, J.;Bodmeier, R.
  20. Microencapsulation of Drugs Controlled release of water-soluble drugs from hollow spheres: Experiments ad model analysis Omi, S.;Furuno, T.;Ikeda, A.;Iso, M.;Urushiyama S.;Yokota, H.