YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Drug Release Control of Poloxamer-Poly(acrylic acid) Interpenetrating Polymer Networks

폴록사머-폴리아크릴산 IPNs의 약물 조절 방출

  • 변은정 (이화여자대학교 약학대학) ;
  • 박주애 (이화여자대학교 약학대학) ;
  • 이승진 (이화여자대학교 약학대학) ;
  • 김길수 (이화여자대학교 약학대학)
  • Published : 1997.02.01
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Abstract

Poloxamer-poly (acrylic acid) (PAA) interpenetrating polymer networks (IPNs) were prepared via matrix polymerization of acrylic acid with poloxamer prepolymer. The equilibrium s welling of poloxamer/PAA IPNs was determined in various pH medium. The swelling of poloxamer/PAA IPNs was more affected by pH difference compared with the swelling of homo PAA gel due to protonation and deprotonation of the PAA network, followed by reversible formation and dissociation of the interpolymer complex due to hydrogen bonding between acidic hydrogens and ether oxygens. Nonionic/anionic/cationic drugs were incorporated into IPN matriceds as a model drug and their release behavior was studied. Nonionic, drug revealed release patterns depending solely on pH dependent swelling kinetics. In contrast, the release of ionic drugs was significantly affected by ionic drug-polymer interaction as well as the swelling kinetics.

Keywords

References

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