YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Synthesis of Azabicyclo[3.2.1]octane Skeleton of Tropane Alkaloid

트로판 알칼로이드의 아자비시크로[3.2.1]옥탄 골격합성

  • Published : 1997.02.01
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Abstract

Synthesis of an optically active azabicyclo[3.2.1]octane skeleton as a backbone of the tropane alkaloids has been achieved by employing intramolecular Mannich reaction. Utilizat ion of (R)-${\alpha}$-methylbenzylamine as a chiral auxiliary provided an excellent cyclization of amino dioxolane precursor. However, this auxiliary did not afford high asymmertic induction for the preparation of the optically active cyclization precursor.

Keywords

References

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