Journal of Pharmaceutical Investigation
- 제27권2호
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- Pages.109-117
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- 1997
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
나프록센의 비선형 체내동태에 미치는 페노바르비탈의 영향
Effect of Phenobarbital on the Nonlinear Pharmacokinetics of Naproxen
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Lee, Yong-Bok
(College of Pharmacy, Chonnam National University) ;
- Chae, Myung-Ae (College of Pharmacy, Chonnam National University) ;
- Koh, Ik-Bae (College of Pharmacy, Chonnam National University)
- 발행 : 1997.06.20
초록
In order to elucidate the effect of phenobarbital (PB) on the nonlinear pharmacokinetic behavior of naproxen (NAP), we compared the dose dependent hepatic intrinsic clearance, biliary excretion and protein binding of NAP in control rats to those in the PB-pretreated rats which were intraperitoneally pretreated with PB sodium (75 mg/kg) once a day for four days. NAP was injected via femoral (1.5 mg/kg) and portal(0.25, 0.5, 1.5, 15 and 30 mg/kg) vein to the control and PB-pretreated rats, respectively. And also, we measured the plasma free fraction of NAP with the equilibrium dialysis method and the biliary excreted total amounts of NAP in both rats. Plasma free fraction of NAP was decreased in lower concentration than
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