Journal of Pharmaceutical Investigation
- 제27권2호
- /
- Pages.99-108
- /
- 1997
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
점막 추출액중 치로트로핀 유리호르몬의 효소적 분해 및 안정화
Enzymatic Degradation and Stabilization of Thyrotropin Releasing Hormone in Various Rabbit Mucosa Extracts
-
Chun, In-Koo
(College of Pharmacy, Dongduk Women's University) ;
- Shin, Dong-Won (College of Pharmacy, Dongduk Women's University)
- 발행 : 1997.06.20
초록
To evaluate the feasibility of mucosal delivery of thyrotropin releasing hormone (TRH) through various mucosae, enzymatic degradation and stabilization of TRH in the nasal, rectal and duodenal extracts of rabbits were studied. TRH in the extracts was assayed by HPLC and its degradation was found to follow apparent first-order kinetics. The residual concentrations of TRH in the mucosal extracts of nasal, rectal and duodenal segments after 24 hr of incubation were found to be
키워드