새로운 Capsaicin 유도체 DA-5018의 구조 및 물리화학적 성질 연구

Structural and Physicochemical Studies on DA-5018, a New Capsaicin Derivative

  • Kim, Heung-Jae (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Lee, Jong-Jin (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Lee, Eung-Doo (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Shim, Hyun-Joo (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Lee, Sang-Deuk (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Ok, Kwang-Dae (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Kim, Won-Bae (Research Laboratories, Dong-A Pharm. Co., Ltd.) ;
  • Park, No-Sang (Korea Research Institute of Chemical Technology (KRICT) Division of Medicinal Chemistry)
  • 발행 : 1997.06.20

초록

The physicochemical and structural properties of new capsaicin derivative, DA-5018, were examined. The reference standard of this compound was obtained by the recrystallization. A method for the determination of the dissociation constant of the compound is described. pH-solubility and distribution coefficient were determined by chromatographic method. Fundamental properties on thermal behaviors were investigated by TG, DTA and DSC. Structural analysis based on spectroscopic method coincided with the chemical structure of DA-5018. Approximate dissociation constant of the compound determined by UV spectral method was 9.35. Solubilities and partition coefficients in various pH buffer solution appeared pH-dependency. No crystal transition or further transition was found in the thermal analysis. This compound showed good stability, but pH 13 buffer and acetone made some degradative products.

키워드