생약학회지 (Korean Journal of Pharmacognosy)

  • 제28권1호
  • /
  • Pages.21-25
  • /
  • 1997
  • /
  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

왕고들빼기로부터 얻은 Triterpene Acetate의 혈청 콜레스테롤 저하효과

Serum Cholesterol Lowering Effect of Triterpene Acetate Obtained from Lactuca indica

  • 김미정 (상지대학교 생체기능과학연구소) ;
  • 이은 (상지대학교 생체기능과학연구소) ;
  • 차배천 (상지대학교 생체기능과학연구소) ;
  • 최무영 (상지대학교 생체기능과학연구소) ;
  • 임태진 (상지대학교 생체기능과학연구소) ;
  • 박희준 (상지대학교 생체기능과학연구소)
  • Kim, Mi-Jeong (Bioscience Research Institute, Sangji University) ;
  • Lee, Eun (Bioscience Research Institute, Sangji University) ;
  • Cha, Bae-Chun (Bioscience Research Institute, Sangji University) ;
  • Choi, Moo-Young (Bioscience Research Institute, Sangji University) ;
  • Rhim, Tae-Jin (Bioscience Research Institute, Sangji University) ;
  • Park, Hee-Juhn (Bioscience Research Institute, Sangji University)
  • 발행 : 1997.03.30
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초록

The diets with three types of triterpenoid constituents, which were isolated from Lactuca indica, provoked significant changes of serum lipoprotein-cholesterol meta bolisms of hypercholesterolemic rats induced by high-cholesterol diet, together with the reduction of atherogenic index. Especially, triterpene acetates which have triterpene moieties such as ${\beta}-amyrin$, ${\alpha}-amyrin$, lupeol, pseudotaraxasterol, taraxasterol and germanicol showed a considerable hypocholesterolemic activity. The rat given orally with triterpene acetates did not exhibit a significantly higher value of atherogenic index than that of normal rats.

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