Synthesis Conditions and Rheological Characteristics of Aluminum Magnesium Silicate

규산알루민산마그네슘의 합성조건과 유동학적 특성

  • Published : 1995.02.01

Abstract

Aluminum magnesium silicate was synthesized by reacting the mixed solutions of sodium aluminate and magnesium chloride with sodium silicate solution in this study. The optimal synthesis conditions based on the yield of the product has been attained according to Box-Wilson experimental design. It was found that the optimal synthetic conditions of aluminum magnesium silicate were as follows: Reaction temperature=$69~81^{\circ}C$; concentration of two reactants, sodium aluminate and magnesium chloride= 13.95~14.44 w/w%; molar concentration ratio of the two reactants, [NaAlO$_{2}$]/MgCl$_{2}$]=3.63~4.00; reaction time= 12~15 min; drying temp. of the product=$70~76^{\circ}C$. Aluminum magnesium silicate synthesized under the optimal synthesis condition was dispersed in 0.75, 1.0 and 1.5w/w% aqueous solution or suspension of six dispersing agents, and the Theological properties of the dispersed systems prepared have been investigated at $15^{\circ}C$ and $25^{\circ}C$ using Brookfield LVT Type Viscometer. The acid-consuming capacity of the most excellent product was 272~278 ml of 0.1N-HCl per gram of the antacid. The flow types of 5.0 w/w% aluminum magnesium silicate suspension were dependent upon the kind and concentration of dispersing agents added. The apparent viscosity of the suspension was generally increased with concentration of dispersing agents and was not significantly changed or decreased as the temperature was raised. A dispersing agent, hydroxypropyl cellulose suspension, exhibited an unique flow behavior of antithixotropy. The flow behavior of the suspension dispersed in a given dispersing agent not always coincided with that of the dispersing agent solution or suspension itself.

Keywords

References

  1. Ger. Offen. v.2 Magnesium aluminum silicate Yokoi,H.;Haginake,T.;Inagaki,M.;Namerikawa,M.
  2. Rom. v.51 Preparation of magnesium alumino silicate gel Hoffmann,K.
  3. Jpn. Kakai Tokyo Koho, JP v.8 Magnesium aluminosilicate as gastric antacid Fuji Kagaku Kogyo Co., Ltd.Jpn.
  4. Jpn. Kakai Tokyo Koho, JP v.59 Magnesium aluminosilicate production for pharmaceuticlas, cosmetics, and foods Nippon Chemical Industrical Co. Ltd. Jpn.
  5. Brit. Medicinal magnesium aluminum silicate Fuji Chemical Industry Co.,Ltd.Jpn.
  6. 품목허가번호 no.131 제조허가사항 일양약품주식회사
  7. I. Arzneim-Forsch v.24 In vitro investigation of antacids Schnekenburger,J.
  8. Acta Pharm. Fenn. v.91 In Vitro evaluations of antacid suspensions marketed in Finland Tuderman,V.;Klinge,E.;Lind,H.
  9. Neusilin A Fuji Kagaku Kogyo Co., Ltd. Jpn.
  10. Federal Register v.38 Revaluation results of OTC antacids by FDA Fuji Chemical Industry Co., Ltd. Jpn.
  11. Yakhak Hoeji v.27 Evaluation of neutralizing capacities of antacid products Kim,N.D.;Park,K.H.;Cha,S.M.;Choi,J.S.
  12. Yakuzaigaku v.25 Studies on antacids Kaku,T.;Hatsumi,Y.
  13. Neusilin A A Collection of Literature on Clinical Tests Fuji Kagaku Kogyo Co., Ltd. Jpn.
  14. J. Soc. Cosmet. Chem. v.32 Rheological properties of magnesium aluminum silicate/xanthan gum dispersions Ciullo,P.A.
  15. Yakhak Hoeji v.35 Synthesis conditions and rheological characteristics of aluminum phosphate Shin,W.W.;Ahn,S.M.;Chung,D.H.;Kang,T.W.;Lee,K.P.
  16. J. Roy. Stat. Soc. Ser. v.B13 On the experimental attainment of optimum conditions Box,G.E.P;Wison,K.B.
  17. 最適反應條件の 追求-Box-Wilson 計劃とは.-化學の領域 v.15 岡用壽太郞
  18. J. Pharm. Sci. v.52 Adaptation of commercial viscometers for special applications in pharmaceutical rheology Ⅰ, The Brookfield Viscometer Wood,J.H.;Catacalos,G.;Lieberman,S.V.
  19. Chem. Ind. v.10 Cheng,D.C.H.