• Membrane and Water Treatment
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• 제9권5호
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• pp.309-315
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• 2018

The applicability of the ultrafiltration process for color removal from dye-containing water has been examined in this study. The optimization of major process variables, such as dye concentration, chitosan concentration and transmembrane pressure on permeate flux and color removal efficiency was investigated. To find the most appropriate results for the experiment, the Box-Wilson experimental design method was employed. The results were correlated by a response function and the coefficients were determined by regression analysis. Permeate flux variation and color removal efficiency determined from the response functions were in good agreement with the experimental results. The optimum conditions of chitosan concentration, dye concentration and pressure were 50 mg/l, 50 mg/l and 3 bars, respectively for the highest permeate flux. On the other hand, optimum conditions for color removal efficiency were determined as 50 mg/l of dye concentration, 50 mg/l of chitosan concentration and 1 bar of pressure.

• 한국구조물진단유지관리공학회 논문집
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• 제19권5호
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• pp.92-103
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• 2015

Box-Wilson 실험계획법은 보통 중심합성계획법으로 알려져 있으며, 변동성이 존재하는 정보를 실험 계획적 방법으로 수집하는 설계 기법이다. 이 방법은 최소의 설계비용으로 가능한 많은 정보를 얻는 목적으로 고안되었다. 본 연구에서는 60 MPa급 고강도 자기충전형 콘크리트(HSSCC)를 대상으로 다양한 성능에 대한 여러 배합인자들의 효과를 효율적으로 파악하고 최적배합을 찾는 과정에 이 방법을 적용하였다. HSSCC의 배합인자(요인)와 물리적 성능(반응) 사이의 비선형적 관계는 2차 다항식으로 반응표면을 근사화 모델링하였으며, 요인점=25=32개, 축점=2k=10개, 중심점은 각 축에서 2번 씩 10개, 총 52개의 실험점에서 물시멘트비, 단위시멘트량, 잔골재비, 단위플라이애쉬량, 단위고성능감수량의 총 5개의 인자에 따른 압축강도, 통과능력, 재료분리저항성, 제조비용, 밀도 등의 총 5개의 반응을 파악하기 위한 실험이 실시되었다. 연구의 결과 Box-Wilson 실험계획법은 배합인자와 반응 사이의 관계를 과학적인 방법으로 계획하고 객관적으로 해석하는 데 매우 효과적이었으며, 수치해석적인 방법으로 최적배합을 계산할 수 있었다.

• Journal of Pharmaceutical Investigation
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• 제26권3호
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• pp.221-232
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• 1996

An abrasive, calcium hydrogen phosphate dihydrate (DCPD), was synthesized in a Box-wilson experimental design by reactions between phosphoric acid and milk of lime, and calcium chloride and sodium phosphate solutions, and stabilized with TSPP and TMP. The optimum conditions for preparation of DCPD from phosphoric acid with milk of lime were such as; reaction temp.; $51.9^{\circ}C$, conc. of lime; 25.9%, conc. of phosphoric acd; 77.9%, drying temp.; $60.2^{\circ}C$ and final pH; 6.46. The physico-chemical and pharmaceutical properties of DCPD were showed as follows: glycerin absorption value(68 ml/100g), whiteness(99.5%), particle size(10.9 nm), pH(7.8), and set test(pass). XRD and SEM of DCPD indicated a monoclinic system crystallographically. $N_2$ adsorption isotherm curve by BET showed non porous type II form. The micromeritic parameters of DCPD showed that surface area was $3.27{\sim}4.6\;cm^{2}/g$ and pore volume, pore area and pore radius were negligible. The rheogram of the toothpaste containing DCPD showed pseudoplastic flow with yield value of 321, and thixotropic behavior forming hysteresis loop. These results meet the requirements as abrasive standard, and sythesized DCPD is expected as a good dental abrasive such as a high quality grade in practice.

• 약학회지
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• 제44권6호
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• pp.545-551
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• 2000

Magnesium trisilicate was prepared by reacting Magnesium sulfate solution with Sodium silicate solution in this study. The optimum synthesis conditions base on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of Magnesium trisilicate were as follows; Reacting temperature : $57{\sim}90^{\circ}C$, Concentration of reactant solution : $19.1{\sim}20.0%$, Molar concentration ratio of two reactants : [Sod.silicate]/[Mg.sulfate] : $1.47{\sim}1.80$, Temperature of washing water : $45{\sim}48^{\circ}C$, Drying temperature : $65{\sim}82^{\circ}C$. The antacidic capacity of the five Magnesium trisilicate samples which shows the maximum antacidic efficacy was tested by pharmacopeia acid consuming capacity test. The five Magnesium trisilicate samples were identified by chemical analysis.

• 약학회지
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• 제45권1호
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• pp.23-28
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• 2001

Hydrotalcite was prepared by reacting with sodium carbonate, magnesium hydroxide and aluminum chloride solutions in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of hydrotalcite were as follows ; reacting temperature : 63~9$0^{\circ}C$, concentration of reactant solution : 18.20~19.82%, molar concentration ratio of two reactants [Mg(OH)$_2$] / (AICl$_3$.6$H_2O$) : 6.0, temperature of washing water : 29.0-34.4$^{\circ}C$, drying temperature : 56-77.6$^{\circ}C$. The physicochemical properties of hydrotalcite as medicine were studied by use of chemical analysis, bulk volume test and acid consuming capacity measurements.

• 약학회지
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• 제43권6호
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• pp.689-695
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• 1999

Hydrotalcite was prepared by reacting with sodium carbonate, magnesium oxide and aluminum sulfate solutions in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. It was found that the optimum synthesis conditions of hydrotalcite were as follows; reacting temperature : 48~63$^{\circ}C$, concentration of reactant solution : about 20%, molar concentration ratio of two reactants [MgO]/[Al. sulfate] ; 7.35~8.1, temperature of washing water : 34.4~37.4$^{\circ}C$, drying temperature : 74~81.5$^{\circ}C$. The physicochemical properties of hydrotalcite as medicine were studied by use of chemical analysis, D.S.C. thermogram, bulk volume test and acid consuming capacity measurements.

• 약학회지
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• 제47권1호
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• pp.5-9
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• 2003

Synthetic aluminum silicate was prepared by reacting aluminum sulfate solution with Sodium silicate solution in this study. The optimum synthesis conditions based on the yield of the product were established by applying Box-Wilson experimental design. The results were found to be as follows; Reactant temperature : 50∼72$^{\circ}C$, Concentration of two reactants : 10∼17.6％, Mole ratio of two reactants, [Sod. silicate]/[Al. sulfate) : 4.6∼5.0, Temperature of washing water : 25∼4$0^{\circ}C$, and Drying temperature of product : 50∼$65^{\circ}C$. The physical and chemical properties of synthetic aluminum silicate as medicine were investigated by means of chemical analysis, adsorption test and acid consuming capacity measurements.

• 약학회지
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• 제46권5호
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• pp.364-368
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• 2002

Optimal synthetic conditions of barium sulfate were investigated from the viewpoint of yield and bulkiness according to a randomized complete block design proposed by Box and Wilson. Barium chloride and Sodium sulfate were utilized as reactants in order to prepare barium sulfate in this study. The optimum Synthesis conditions of barium sulfate obtained from this study are as follows; Reactant temperature; 60~75$^{\circ}C$ (viewpoint of yield) and 60~71$^{\circ}C$ (viewpoint of bulkiness). Concentration of two reactants; 12.7~14.4％ (viewpoint of yield) and 5~10.5％ (viewpoint of bulkiness). Mole ratio of two reactants, [BaCl$_2$]/[Na$_2$SO$_4$]; 1.62~1.96 (viewpoint of yield) and 2.0 (viewpoint of bulkiness). Reacting time; 13~15 minutes (viewpoint of yield) and 12~14 minutes (viewpoint of bulkiness). Drying temperature of product; 86~10$0^{\circ}C$ (viewpoint of yield) and 6$0^{\circ}C$ (viewpoint of bulkiness).

• 약학회지
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• 제35권4호
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• pp.319-325
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• 1991

Aluminum phosphate gel was synthesized by reacting aluminum sulfate as a soluble aluminum salt to tribasic sodium phosphate in this study. The optimal synthesis conditions based on the yield of product were investigated by applying Box-Wilson experimental design. It was found that optimal synthesis conditions were as follows: Reaction temperature; $61~71^{\circ}C$, concentration of two reactants; 12.27~13.83%, concentration ratio of two reactants; [AI$_{2}$(SO$_{4}$)$_{3}$]/[Na$_{3}$PO$_{4}$]= 0.5, reaction time; 10.9~12.1 minutes, drying temperature of product; $60~72^{\circ}C$. Aluminum phosphate gel prepared by the optimal synthesis conditions was suspended with four types of natural and synthetic gums at the concentration of 0.375~1.5wv%. Their Theological properties of aluminum phosphate gels were examined with Haake-Rotovisco RV 20 rotational viscometer. It showed that the higher concentration of suspending agents and lower temperature, the higher viscosity. Aluminum phosphate gel suspended by pectin and agar showed plastic flow with rheopexy, and their gels suspended by sodium alginate and sod. CMC showed plastic flow with thixotropy.

• 약학회지
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• 제33권2호
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• pp.111-117
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• 1989

The optimum reaction conditions for the acid consuming capacity of aluminum silicate synthesized from the reaction of sodium silicate solution and potassium aluminum sulfate solution were investigated by Box-Wilson experimental design, and the micromeritic properties were examined by the means of BET $N_2$ adsorption, Hg penetrometer and methylen blue adsorption. The chemical composition of the samples were analyzed by gravitic method. The results were found to be as follows: optimum reaction temperature $54.7^{\circ}C$, both concentrations of reactant soln 15.7%, reactants molar ratio (Al/Si) 0.5 and drying temperature $65.0^{\circ}C$. The acid consuming capacity of the sample prepared by above optimum conditions was 68 ml and the chemical composition was $Al_2O_3{\cdot}3.6SiO_2{\cdot}3H_2O$. The relationship between acid consuming capacity and micromeritic properties could not found in the range of experiments. Therefore, it is assumed that the acid consuming mechanism of aluminum silicate depends on the neutralization of $Al_2O_3$ and buffer action of $SiO_2$ in sample.