YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Antitumor Activity of Reaction Mixture of Chitin and Green Onion Extract

키틴과 파추출액 반응물의 항암 작용

  • Kim, Yeong-Shik (Natural Products Research Institute, Seoul National University) ;
  • Park, Kyung-Shin (Natural Products Research Institute, Seoul National University) ;
  • Chang, Il-Moo (Natural Products Research Institute, Seoul National University) ;
  • Hyun, Jin-Won (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
  • Park, Jae-Gahb (Laboratory of Cell Biology, Cancer Research Institute and Cancer Research Center, College of Medicine, Seoul National University) ;
  • Park, Ho-Koon (Korea Institute Science and Technology)
  • 김영식 (서울대학교 천연물과학연구소) ;
  • 박경신 (서울대학교 천연물과학연구소) ;
  • 장일무 (서울대학교 천연물과학연구소) ;
  • 현진원 (서울대학교 의과대학) ;
  • 박재갑 (서울대학교 의과대학) ;
  • 박호군 (한국과학기술연구원)
  • Published : 1994.10.30
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Abstract

Antitumor activity was tested by administration of reaction mixture of green onion extract and chitin to mice bearing sarcoma-180 cells. An intraperitoneal injection of mixture(20 mg/kg/day) to mice Have an 52% inhibition of tumor growth. Inhibition of tumor growth was found to be dose-dependent. When eighty miligrams of the mixture were administered, the weight of tumor was reduced significantly. HPLC analysis indicated the mixture was composed of N-acetyl-D-glucosamine, N-acetylchitobiose and N-acetylchitotriose.

Keywords