YAKHAK HOEJI (약학회지)
- Volume 38 Issue 5
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- Pages.586-594
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- 1994
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- 0377-9556(pISSN)
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- 2383-9457(eISSN)
General Pharmacology of DWQ-013, A New Synthetic Quinolone Antibiotics (Effects on the Central Nervous System)
신규 합성 퀴놀론계 항생물질(DWQ-013)의 일반 약리 작용 -중추신경계에 대한 작용-
- Lim, Seung-Wook (R & D Center, Daewoong pharmaceutical Co.) ;
- Kim, Young-Man (R & D Center, Daewoong pharmaceutical Co.) ;
- Yu, Young-Hyo (R & D Center, Daewoong pharmaceutical Co.) ;
- Lee, Jae-Wook (R & D Center, Daewoong pharmaceutical Co.)
- Published : 1994.10.30
Abstract
The general pharmacological effects of DWQ-013, a new synthetic quinolone antibacterial agent, were examined on the central nervous system in experimentral animals and the following results were obtained. Drug interaction of DWQ-013 with theophylline, fenbufen and nonsteroidal antiinflammatory drugs was also examined. DWQ-013 decreased touch escape effect on the general behavior and decreased body temperature at a concentration of 1000 mg/kg in mice. But DWQ 013 had no effect on the locomotor activity, rotarod perfomance and traction test in mice. Furthermore, DWQ-013 increased pentobarbital-induced sleeping time and affected the onset time in acetic acid-induced writhing test in mice. DWQ-013 reduced onset time and death time on strychnine-induced convulsions and death time on pentylenetetrazole-induced convulsions at a concentration of 1000 mg/kg in mice. But, the drug had no effect on the electroshock. DWQ-013 did not interact with fenbufen and any other NSAIDs but it did interact with theophylline. From these results, it could be suggested that DWQ-013 had less pharmacological effect than other quinolones on the central nervous system.