YAKHAK HOEJI (약학회지)
- Volume 38 Issue 5
- /
- Pages.511-515
- /
- 1994
- /
- 0377-9556(pISSN)
- /
- 2383-9457(eISSN)
Inhibitory Activitv of (1,3-Dioxolan-2-yl and Dioxan-2-yl)methylaminium Derivatives against Acetylcholinesterase
Acetylcholinesterase에 대한 (1,3-Dioxolan-2-yl 및 Dioxan-2-yl)methylaminium유도체의 저해 작용
- Phi, Taek-San (Agency for Defense Development) ;
-
Kim, Yun-Bae
(Agency for Defense Development)
;
- Kim, Jee-Cheon (Agency for Defense Development) ;
-
Cho, Young
(Agency for Defense Development)
;
-
Sok, Dai-Eun
(Agency for Defense Development)
;
- Cha, Seung-Hee (Agency for Defense Development) ;
- Seo, Won-Jun (Agency for Defense Development)
- 피택산 (국방과학연구소) ;
-
김윤배
(국방과학연구소)
;
- 김지천 (국방과학연구소) ;
-
조영
(국방과학연구소)
;
-
석대은
(국방과학연구소)
;
- 차승희 (국방과학연구소) ;
- 서원준 (국방과학연구소)
- Published : 1994.10.30
Abstract
We examined the inhibitory activity of (1,3-dioxolan-2-yl and 1,3-dioxan-2-yl)methylaminium derivatives(A; 1-8) against acetylcholinesterase. Derivatives of six-membered 1,3-dioxane exhibited more potent inhibitory effect than corresponding 5-membered 1,3-dioxolanes. The presence of methyl group at C4 position of dioxane ring was effective to increase the inhibitory potency of heterocyclic analogues. The activity of N-phenacyl-aminiums was greater than that of N,N,N-trimethyl-aminiums. In general, the terminal methyl group on 1,3-dioxane ring and the phenacyl group in ammonium compound A were assumed to be important factors to enhance the inhibitory action.
Keywords