The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 27 Issue 1
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- Pages.104-111
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- 1993
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- 1225-6714(pISSN)
Trace Element Analysis by Neutron Activastion Analysis in the Human Cancer Tissue
폐암조직에서 중성자 방사화 분석법을 이용한 미량 원소 분석
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Lim, Sang-Moo
(Department of Nuclear Medicine, Korea Cancer Center Hospital) ;
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Zo, Jae-Il
(Department of Thoracic Surgery, Korea Cancer Center Hospital) ;
- Shim, Young-Mog (Department of Thoracic Surgery, Korea Cancer Center Hospital) ;
- Chung, Young-Ju (Korea Atomic Energy Research Institute) ;
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Cho, Seung-Yeon
(Korea Atomic Energy Research Institute) ;
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Chung, Yong-Sam
(Korea Atomic Energy Research Institute)
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임상무
(원자력병원 핵의학과) ;
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조재일
(원자력병원 흉부외과) ;
- 심영목 (원자력병원 흉부외과) ;
- 정영주 (한국원자력 연구소) ;
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조승연
(한국원자력 연구소) ;
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정용삼
(한국원자력 연구소)
- Published : 1993.06.15
Abstract
Trace elements are important components in the biological system, as a structural material and metabolic controller. Neutron activation analysis (NAA) with high neutron flux and high energy resolution Ge (Li) detector coupled to multichannel analyzer (MCA) has been one of the most accurate method for the determination of ultra-trace level components, and is applicable to biological material. In human body, the NAA can be used for quantitation of trace elements in various organs and tissue with endocrinological and metabolic disease and industrial metal poisoning. In this study, Triga Mark III nuclear reactor in Korea Atomic Research Institute was used for quantitation of trace eleement in human lung cancer tissues by neutron activation analysis. In the squamous cell carcinoma tissues, Br, Hg, La, Sb, Sc, Cl, Fe and I content were lower than normal lung tissues, and K, Rb and Se content were higher. In the adenocarcinoma tissues, Fe, Au, La, Sc and Zn content were lower than normal lung tissues, and Rb, Co and Se content were higher. Rb content was higher in the adenocarcinoma tissues than in the squamous cell carcinoma tissues. Fe and Na content were higher in the squamous cell carcinoma tissues than in the adenocarcinoma tissues.