Journal of Pharmaceutical Investigation
- Volume 23 Issue 1
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- Pages.27-32
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
Drug Interaction Between Phenytoin and Diltiazem in Rabbit
딜티아젬과 페니토인과의 약물상호작용
- Choi, Jun-Shik (College of Pharmacy. Chosun University) ;
- Chang, Il-Hyo (Department of Pharmacy. Kwangju Christian Hospital)
- Published : 1993.03.20
Abstract
Pharmacokinetic drug interaction between phenytoin and diltiazem was investigated following i.v. administration concomitantly to rabbits. Diltiazem was coadministered at doses of 1, 2 and 3 mg/kg, respectively, with phenytoin (5 mg/kg) to rabbits. Plasma concentration and AUC of phenytoin were increased significantly, but volume of distribution and total body clearance were decreased significantly (p<0.05) at doses of 2 mg and 3 mg/kg of diltiazem. From the results of this experiment, it is desirable that dosage regimen of phenytoin should be adjusted and that therapeutic drug monitoring should be practiced for reduction of side or toxic effect when phenytoin should be administered with diltiazem in clinical practice.
Keywords
- Pharmacokinetic interaction;
- Phenytoin;
- Diltiazem;
- Coadministration;
- Total body clearance;
- Distribution rate constant;
- Dosage regimen;
- Area under the curve (AUC)