Journal of Pharmaceutical Investigation
- Volume 23 Issue 1
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- Pages.33-39
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- 1993
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- 2093-5552(pISSN)
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- 2093-6214(eISSN)
The Effect of Cholesterol on the Property of Vesicle
Vesicle의 성질에 대한 콜레스테롤의 효과
- Cho, Iw-Han (Department of Advanced Materials Engineering, Korea Advanced Institute of Science and Technology) ;
- Moon, Kwon-Gi (Department of Chemistry, Chungbuk National University) ;
- Shin, Jae-Sup (Department of Chemistry, Chungbuk National University)
- Published : 1993.03.20
Abstract
Polymerized vesicles were prepared from monomeric cholesterol-containing surfactant. These vesicles were used to extract the free cholesterol. To introduce spacer group into [cholesteryloxycarbonylmethyl] [2-(methacryloyloxy)ethyl]dimethylammonium chloride (CHODAMA), [5-[ (cholesteryloxy)carbonyl]pentyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-5) and [10-[(cholesteryloxy)carbonyl]decyl] [2-(methacryloyloxy)ethyl]dimethylammonium bromide (CHODAMA-10) were synthesized, In both case of polymerized vesicle with CHODAMA-5 and CHODAMA-10, the permeability was decreased and the amount of extracted cholesterol was also decreased, compared with the polymerized vesicle of CHODAMA.