Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effect of Dietary Coenzyme ${Q}_{10}$ on Lipid Peroxidation in Adriamycin-Treated Rats -III. Effect on Myocardial Ultrastructural Changes-

식이 중의 Coenzyme ${Q}_{10}$ 첨가가 Adriamycin을 투여한 흰쥐의 체내 지질과산화에 미치는 영향 -III. 심근 미세구조 변화에 미치는 영향-

  • Seo Jung Sook (Department of Food & Nutrition Yeungnam University)
  • Published : 1992.10.01
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Abstract

The present study was designed to evaluate the effect of pretreatment with coenzyme {{{{ { Q}_{10 } }}}} on adriamycin-induced myocardial ultrastructural changes in rats. Except control group 6 treat-ments included three levels of dietary conenzyme {{{{ { Q}_{10 } }}}} (0, 0.1 or 0.5g/kg diet) and two levels of ADR(1.0 or 2.0mg/kg B.W/week) Adriamycin treatment significantly decreased growth perfo-rmance of rats. But this decrement was not modified by dietary supplementation of coenzyme{{{{ { Q}_{10 } }}}} Electron microscopic examination revealed a progression of myocardial lesions were depen-dent upon the level of ADR injection. The most frequently observed fin structural alterations in rat myocardium were mitochondrial swelling dilation of the sarcoplasmic reticulum and the appearance of a perinuclear vacuolication. But these structural changes were somewhat reduced by dietary supplementation of coenzyme {{{{ { Q}_{10 } }}}}.

식이중에 첨가된 coenzyme ${Q}_{10}이 ADR을 투여한 흰쥐의 심근미세구조 변화에 미치는 영향을 검토하기 위하여 ADR 2수준(1.0 및 2.0mg/kg B.W/week)과 coenzyne ${Q}_{10} 3수준(0, 0.1및 0.5g/kg diet)에 의한 6개의 실험군과 basal diet만을 공급하는 대조군을 설정하여 8주간 실험동물을 사육하였다. 체중증가량은 ADR의 투여수준이 높을수록 유의적으로 감소되었으나 coenzyme ${Q}_{10}급여에 의한 회복효과는 나타나지 않았다. 전자현미경을 통한 관찰결과, ADR투여는 심근세포내 미세구조의 변성을 유도함이 확인 되었고 특히 mitochondria를 비롯한 세포기관의 소실 및 파괴를 관찰할 수 있었으나 coenzyne ${Q}_{10}을 미리 급여한 군에서는 그정도가 완화되었다.

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