대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.113.3-114
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- 2003
An aqueous extract isolated from Platycodon grandiflorum reduced acetaldehyde-induced collagen and alpha-SMA expression in hepatic stellate cells
- Lee, Kyung-Jin (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
- Shin, Dong-Weon (Division of Food Science, Chinju International University) ;
- Chung, Young-Chul (Korea Research Institute of Chemical Technolog) ;
- Kim, Young-Sup (Department of R&D, Jangsaeng Doraji Co., Ltd.) ;
- Ryu, Si-Yung (Department of R&D, Jangsaeng Doraji Co., Ltd.) ;
- Roh, Sung-Hwan (Department of R&D, Jangsaeng Doraji Co., Ltd.) ;
- Jeong, Hye-Gwang (Department of R&D, Jangsaeng Doraji Co., Ltd.)
- 발행 : 2003.10.01
초록
The increased deposition of extracellular matrix by hepatic stellate cells following liver injury in a process known as activation is considered a key mechanism for increased collagen content of liver during the development of liver fibrosis. In this study, we investigated the protective effects of an aqueous extract from the roots of Platycodon grandiflorum A. DC (Campanulaceae), Changkil (CK), on hepatic fibrosis in hepatic stellate cells. We report that CK reduces the accumulation of collagen in acetaldehyde-induced hepatic stellate cells. (omitted)
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