대한약학회:학술대회논문집 (Proceedings of the PSK Conference)

대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Inhibition of cyclooxygenase-2 expression by Caffeoyl-4-dihydrocaffeoyl quinic acid in macrophages

  • Chung, Yung-Chul (Division of Food Science, Jinju International University) ;
  • Choi, Chul-Yung (Department of Pharmacy and Research Center for Proteineous Materials, Chosun University) ;
  • Kim, Ji-Young (Korea Research Institute of Bioscience and Technology) ;
  • Chun, Hyo-Kon (Korea Research Institute of Bioscience and Technology) ;
  • Gho, Young-Hee (Korea Research Institute of Bioscience and Technology) ;
  • Jeong, Hye-Gwang (Korea Research Institute of Bioscience and Technology)
  • 발행 : 2003.10.01
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초록

Inducible cyclooxygenase-2 (COX-2) has been implicated in the processes of inflammation and carcinogenesis. Thus, the potential COX-2 inhibitors have been considered as anti-inflammatory or cancer chemopreventive agents. In this study, we investigated the effect of Caffeoyl-4-dihydrocaffeoyl quinic acid (CDCQ) isolated from Salicornia herbacea on the expression of cyclooxygenase (COX-2) in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages. When CDCQ was treated with LPS, the prostaglandin $E_2$ production and COX-2 gene expression induced by LPS were markedly reduced in a dose-dependent manner. (omitted)

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