대한약학회:학술대회논문집 (Proceedings of the PSK Conference)
- 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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- Pages.114.1-114.1
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- 2003
Effects of Mancozeb on cell-mediated immunity in mice.
- Chung, Ae-Hee (Seoul Metropolitan Government Research Institute of Public Health & Environment and Sookmyung Women's University) ;
- Pyo, Myoung-Yun (Seoul Metropolitan Government Research Institute of Public Health & Environment and Sookmyung Women's University)
- 발행 : 2003.10.01
초록
Mancozeb is a protective fungicide on plants and a polymeric complex of ethylene bisdithiocarbamate manganese with zinc salt. It is reported to induce teratogenic and carcinogenic effect in laboratory animals. But the immunomodulating effects of Mancozeb exposure have not been systemically evaluated. The purpose of this study was to investigate the effects of Mancozeb on cell-mediated immunity in mice. For ex vivo assessment, mice were orally exposed to Mancozeb dissolved in distilled water as concentrations of 2,500, 5,000, 10,000 mg/kg for single occasion (acute exposure) or 250, 1,000, 1,500 mg/kg/day 5 days a week for 30days(subacute). (omitted)
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