Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)
- 2003.10b
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- Pages.171-171
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- 2003
Structure-Related Cytotoxicity and Anti-Heaptofibric Effect of Asiaticoside Derivatives in Rat Hepatic Stellate Cell Line, Hsc-T6
- Kim, Jeong-Ran (School of Lifesciences and Biotechology, Korea University) ;
- Jung, Seung-Hyun (School of Lifesciences and Biotechology, Korea University) ;
- Lee, Eung-Seok (College of Pharmacy, Yeungnam University) ;
- Lee, Eun-Joo (Life Science Research Center, SK chemicals) ;
- Yi, Jung-Bum (Life Science Research Center, SK chemicals) ;
- Lee, Namkyu (Life Science Research Center, SK chemicals) ;
- Cho, Yong-Baik (Life Science Research Center, SK chemicals) ;
- Kwak, Wie-Jong (Life Science Research Center, SK chemicals) ;
- Park, Young-In (College of Pharmacy, Yeungnam University)
- Published : 2003.10.01
Abstract
Asiaticoside, a biologically active triterpenoid present in Centella asicatica, has been known to exert a variety of biological effect such as wound-healing, hepatoprotective, anti-inflammatory. In this study, we observed the effect of asiatic acid asiaticoside and its 16 derivatives on the cytotoxicity and the content of hydroxyproline in rat hepatic stellate cell line, HSC-T6 cell as a preliminary study for screening the anti-hepatofibrotic effect.(omitted)