Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Mild Hyperthermia-induced Cell Cycle Arrest under P53-dependent Pathway in Human Cells

  • Jung, Hwa-Jin (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Yim, Sung-Vin (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Park, Seungjoon (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Jung, Joo-Ho (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Jung, Jee-Chang (Department of Pharmacology, College of Medicine, Kyung Hee University) ;
  • Seo, Young-Rok (Department of Pharmacology, College of Medicine, Kyung Hee University, Corresponding author)
  • Published : 2003.10.01
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Abstract

p53 has identified as a tumor suppressor protein to protect cells from DNA damage. p53, also well known for a transcription factor, can activate genes such as p21, bax, gadd45 and induce a number of the responses such as differentiation, senescence, DNA repair, apoptosis and the inhibition of angiogenesis to protect cells. Many mechanisms of p53 activation have been studied.(omitted)

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