Proceedings of the Korean Society of Toxicology Conference (한국독성학회:학술대회논문집)

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Non-radio isotopic endpoint for local lymph node assay in Balb/c mice using ELISA based on Bromdeoxyuridine incorporation

  • Lee, Jong-Kwon (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Park, Jae-Hyun (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Kim, Hyung-Soo (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Yun, So-Mi (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Chung, Seung-Tae (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Juno H. Eom (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Park, Seung-Hee (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Gi ho Seo (Division of Immunotoxicology, National Institute of Toxicological Research) ;
  • Oh, Hye-Young (Division of Immunotoxicology, National Institute of Toxicological Research)
  • Published : 2002.11.01
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Abstract

A murine local lymph node assay (LLNA) has been developed as an alternative test to guinea pig maximization test. The disadvantage of LLNA is the need for the use of radioactive material. In this study, we aimed to investigate the development of non-radio isotopic endpoint for local lymph node assay in Balb/c mice using Enzyme-linked immunosorbent assay (ELISA) based on Bromodeoxyuridine (BrdU) incorporation.(omitted)

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