• Journal of Home Health Care Nursing
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• v.27 no.2
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• pp.156-168
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• 2020

Purpose: This study aimed to examine factors influencing health-related quality of life (HRQOL) and compare them between young-aged and old-aged patients with cancer. Methods: Data of 291 patients (young-aged: 168, old-aged: 123) were obtained from the 10th wave of the 2015 Korea Health Panel Survey. The HRQOL was measured using the Korean version of Euro-QoL-5D. Independent t-test, analysis of variance, and multiple regression analysis were performed to identify factors influencing HRQOL. Results: The average HRQOL score was 0.87±0.10 and 0.82±0.15 among young-aged and old-aged, respectively. The factors differed partially between the two groups. For young-aged, the influencing factors were activity restriction, subjectively perceived health status, and smoking. For old-aged, the influencing factors were activity restriction, subjective health status, and unmet healthcare needs. Conclusion: Strategies to improve the HRQOL of elderly adults need to be developed considering the age group. Additionally, studies that include clinical factors such as symptoms are required to prepare need-based practical approaches for better quality of life of such patients.

• Archives of Pharmacal Research
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• v.17 no.4
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• pp.226-230
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• 1994

The characteristics of voltage-dependent ^{45}Calcium$ uptake and norepinephrine release as factors controlling neural activities in the hypothalamus which is an important regulatory site for cardiovascular function wre studied. Two groups of animals : male spontaneously hyperterisive rat (SHR) and age-matched nomotensive wistar rat (NW) were used in this study. Animals at 4, 6 and 16 weeks of age were sacrificed by decapitiation and the hypothalamus was dissected out. Voltage-dependent calcium uptake and norepinephrine release were determined from hypothalamic synaptosomes either in low potassium (5 mM) or high potassium (41 mM) stimulatory conditions by using ^{45}Ca$ isotope and HPLC-ECD techniques. Degrees of voltage-dependent ^{45}Calcium$ uptake and norepinephrine release evoked by calcium uptake in the hypothalamus of prehypertensive phase (4 weeks old) of SHR were significantly smaller than those in NW of the same age. However, in the developmental phase (6 weeks old) and the established phase (16 weeks old) of hyperrtension in SHR, degrees of voltage-dependent ^{45}Calcium$ uptake and norepinephrine release were similar to those of age-matched normotensive wistae eats. These data imply that the deficit in hypothalamic norepinephrine release might be an important underlying factor for the development of hypertension in SHR.

• Korean Journal of Child Studies
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• v.7 no.1
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• pp.67-84
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• 1986

The purpose of the present research was to investigate cross-modal transfer, especially tactual-to-visual transfer in infancy and to study the relation between failure of cross-modal transfer performance and length of familiarization period. The subjects of this study were 60 infants, 10 boys and 10 girls at each level: six, nine, and twelve months of age. All were normal, healthy, full-term babies. The mothers' educational achievement was controlled at more than 12 years of schooling. There were two separate experimental conditions, one 30-sec and one 60-sec familiarization period. Each experimental condition consisted of a tactual familiarization and a visual recognition memory test. Each child was presented with these 2 sets of cross-modal stimuli in one of the 2 experimental conditions. Infants' visual responses in the visual recognition memory test were videotaped for 20 seconds. Visual fixation time to novel and familiar stimuli was observed throughout the test. The data was analyzed with t-test, percentage of total fixation time to novel stimuli, and ANOVA. The results showed that: 1) Significant differences were found in the cross-modal transfer performance from touch to vision between the 3 age groups. This is, 6 and 9 month old infants didn't show cross-modal transfer in the 30-sec condition, but 12 month old infants did show cross-modal transfer in the 30-second. 2) In all 3 age groups, no significant differences were found in cross-modal transfer performance between the two conditions.

• Journal of Family Relations
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• v.22 no.2
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• pp.3-25
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• 2017

Objective: The purpose of this study was to examine the reliability and validity of the Korean version of the Helicopter Parenting Scale (HPS) using a sample of Korean young adults aged 19-34. This study is to expand the previous validation studies that exclusively focused on college students. Method: The survey data came from 1,140 young adults (398 19-24 year olds, 376 25-29 year olds, and 366 30-34 year olds) who had never been married and had at least one living parent. The young adults' perceived helicopter parenting was assessed by 10 items of the HPS for the mother and the father separately. All of the analyses including exploratory and confirmatory factor analyses were conducted for three age groups (19-24, 25-29, and 30-34 years) and for the mother and the father separately. Results: We found that three items were problematic for all age groups and for both the fathers' and mothers' helicopter parenting. After removing these three items, confirmatory factor analyses showed that the one-factor model fit our data well and the estimated factor loadings were suitable. The results were consistent throughout the age groups and the parent's gender. We also confirmed criterion-related validity using correlations between paternal and maternal helicopter parenting and three dimensions of parental career expectations indicated a reliable. Conclusion: The Korean version of HPS with seven items was found to be a reliable and valid measure for Korean young adults aged 19-34 years old.

• Speech Sciences
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• v.14 no.1
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• pp.63-72
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• 2007

In this study, the researchers evaluate the hypothesis that the reaction time (RT) in the brain is largely dependent on age and gender. The researchers tested English and Korean words using two types: reading as visual stimuli, and listening as auditory stimuli. The E-Prime program installed in functional magnetic resonance imaging (f-MRI) was used. There are 136 Korean subjects in three groups: 30 children (5th and 6th grade elementary school students), 76 young adults (college students), and 30 adults (35-53 years old). In the listening test, the variation for the two languages was different among the three age groups, regardless of gender, whereas the data did not show meaningful differences in the reading test. The findings will provide some meaningful information regarding perception and acquisition of a foreign language.

• Laboraroty Animal Research
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• v.34 no.4
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• pp.176-184
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• 2018

In this study, we observed chronological changes in the immunoreactivity and expression level of myelin basic protein (MBP), one of the most abundant proteins in the central nervous system, in the hippocampus of Zucker diabetic fatty (ZDF) rats and their control littermates (Zucker lean control; ZLC). In the ZLC group, body weight steadily increased with age; the body weight of the ZDF group, however, peaked at 30 weeks of age, and subsequently decreased. Based on the changes of body weight, animals were divided into the following six groups: early (12-week), middle (30-week), and chronic (52-week) diabetic groups and their controls. MBP immunoreactivity was found in the alveus, strata pyramidale, and lacunosum-moleculare of the CA1 region, strata pyramidale and radiatum of the CA3 region, and subgranular zone, polymorphic layer, and molecular layer of the dentate gyrus. MBP immunoreactivity was lowest in the hippocampus of 12-week-old rats in the ZLC group, and highest in 12-week-old rats in the ZDF group. Diabetes increased MBP levels in the 12-week-old group, while MBP immunoreactivity decreased in the 30-week-old group. In the 52-week-old ZLC and ZDF groups, MBP immunoreactivity was detected in the hippocampus, similar to the 30-week-old ZDF group. Western blot results corroborated with immunohistochemical results. These results suggested that changes in the immunoreactivity and expression of MBP in the hippocampus might be a compensatory response to aging, while the sustained levels of MBP in diabetic animals could be attributed to a loss of compensatory responses in oligodendrocytes.

• MALSORI
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• v.68
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• pp.17-32
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• 2008

The purpose of the present study is to investigate syntactic development of Korean by analysing the spontaneous speech data. Thirty children(3, 5, and 7-year-old and 10 per each age group) and 10 adults are employed as subjects for this study. Speech data were recorded and transcribed in orthography. Transcribed data are analysed syntactically: sentence(simple vs complex) patterns and clause patterns(4 basic types according to the predicate) etc. The results are as follows: 1) simple sentences show higher frequency for the upper age groups, 2) complex sentences with conjunctive and embedded clauses show higher frequency for the upper age groups.

• Korean Journal of Applied Biomechanics
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• v.15 no.3
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• pp.51-59
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• 2005

To examine the influence of aging on the mechanism of muscle fatigue, we compared the magnitude of central and peripheral fatigue in young and old women before, during and after a sustained submaximaI isometric contraction of elbow flexor muscles. Twelve women (6 young. $20.7{\pm}1.2$ years and 6 old, $68.8{\pm}29$ years) performed a contraction at 20% of maximal voluntary contraction (MVC) torque with their non-dominant arm. The old women were weaker than the young women, however their endurance time for the 20% contraction was longer compared with the young women ($1822{\pm}444$ vs. $1061{\pm}678$ sec, P <. 05). Both groups had a similar reduction in voluntary activation ratio (VA) during and after the fatiguing contraction. However, the old women showed much greater variability in VA before and after the contraction ($91.61{\pm}4.54%$ and $76.70{\pm}19.55\;%$ range of $79{\sim}99$ to $87{\sim}99%$ respectively) compared with the young women ($95.71{\pm}1.86\;%$ and $83.46{\pm}7.57\;%$ range of $39{\sim}75$ to $69{\sim}90%$, respectively). Furthermore, the EMG activity of the elbow flexor muscles and triceps brachii was greater for the old women compared with the young women throughout the fatiguing contraction, indicating different activation strategies with age. Indices of peripheral fatigue including twitch properties, showed that fatigue within the muscle was more rapid for the young women compared with the old women. These results suggest that although old women are weaker than young women, they have greater endurance due to mechanisms within muscle. Furthermore, old women showed great variability in their ability to optimally activate all muscle fiber compared with young women for an isometric contraction.

• International Journal of Costume and Fashion
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• v.5 no.1
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• pp.1-13
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• 2005

Two hundreds of female aged 19 years old and up were recruited to evaluate the postural changes and bilateral variation of asymmetry over age. To find out the differences among the age group, subjects were classified into 5 groups, early young age(19-29), late young age(30-39), early middle age(40-49), late middle age(50-59), and old age(60-). 35 body measurements were taken by the 3-D body scanner which allowed us to take measurements which cannot be measured using traditional methods, including the shape of a cross section, slice area surface are, and volume. Bilateral variations were observed as a function of age; Depth of scapular point level, scapular point to center back, and blade angle. Postural change of anterior cervical angle, upper anterior thoracic angle, upper posterior thoracic angle, posterior cervical angle, and center back/center front ratio were also exhibited. In each measurements, subjects were classified into normal, and abnormal group. Percentiles of abnormal in shoulder line angle, blade angle, neck point $\∼$ acromial point $\∼$ scapular point, posterior cervical angle, and upper posterior thoracic angle were increased over age group. The upper body of lateral view was classified into 3 types of posture based on the previous research; straight, erect(leaning back), and stooped(bent forward). The percentiles of subjects who have straight postures were decreased as a function of age, but those of stooped postures were increased. Subjects who have erect postures did not so. The stooped posture group shows the big cervical fossa angle, anterior cervical angle, posterior cervical angle, upper posterior thoracic angle, and the small upper anterior thoracic angle comparing to the straight and erect posture group. These results could be apply for clothing construction reflecting the changes in back, shoulder, neck, and the bilateral asymmetry according to the target age group.

• Allergy, Asthma & Respiratory Disease
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• v.6 no.6
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• pp.295-302
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• 2018

Purpose: It is thought that Mycoplasma pneumoniae infection is more prevalent and causes more severe pneumonia in school-age children and young adults than in preschool children; however, recent studies suggest that the infection may be underdiagnosed and more severe in preschool children. This study investigated the clinical characteristics of Mycoplasma pneumoniae pneumonia (MPP) and the risk factors of refractory MPP (RMPP) by age. Methods: We retrospectively reviewed the medical records of 353 children admitted due to MPP from January 2015 to December 2016. Demographics, clinical information, laboratory data and radiological findings were collected from all patients in this study. The patients were divided into 2 groups by the age of 6 years. Also, both preschool (< 6 years old) and school-age (${\geq}6$ years old) children were divided into RMPP and non-RMPP patients. Results: Total febrile days, febrile days before admission and the duration of macrolide antibiotic therapy were significantly longer in school-age children than in preschool children. School-age children had significantly greater risk of lobar consolidation (P=0.036), pleural effusion (P=0.001) and extrapulmonary complications (P=0.019). Necrotizing pneumonia and bronchiolitis obliterans tended to occur more frequently in preschool children than in school-age children. In both preschool and school-age children, lactate dehydrogenase (LDH) levels were significantly higher in RMPP patients than in non-RMPP patients. In preschool children, LDH > 722 IU/L (odds ratio [OR], 3.02; 95% confidence interval [CI], 1.44-6.50) and ferritin > 177 ng/mL (OR, 5.38; 95% CI, 1.61-19.49) were significant risk factors for RMPP, while LDH > 645 IU/L (OR, 4.12; 95% CI, 1.64-10.97) and ferritin > 166 ng/mL (OR, 5.51; 95% CI, 1.59-22.32) were so in school-age children. Conclusion: Clinical features of MPP were significantly different between preschool and school-age children. LDH and ferritin may be significant factors of RMPP in preschool and school-age children.