• 한방재활의학과학회지
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• 제28권1호
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• pp.1-17
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• 2018

Objectives The purpose of this study was to evaluate the effect of Jeopgolsan (JGS) extract on anti-oxidant, anti-inflammatory activities in RAW 264.7 cells and on factors related with fracture healing in skull fractured rat. Methods Experimental animals were divided into four groups: normal group without any treatment (Normal), contral group were treated orally with distilled water (Control), Experimental group were treated orally with JGS at a concentration of 200 mg/kg/day (JGS 200) and Experimental group were treated orally with JGS at a concentration of 200 mg/kg/day (JGS 400). Rats in each group except the normal group were induced fractures in the skull. The 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity and 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid (ABTS) radical scavenging activity were measured to evaluate antioxidant activity. The production of nitric oxide (NO), $interleukin-1{\beta}$ ($IL-1{\beta}$), interleukin-6 (IL-6) and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) in the RAW 264.7 cells were measured to evaluate anti-inflammatory activity. The production of osteocalcin calcitonin, carboxy-terminal telepeptides of type II collagen (CTX II), transforming growth $factor-{\beta}$ ($TGF-{\beta}$), bone morphogenetic protein-2 (BMP-2), Insulin and alkaline phosphatase (ALP) in serum of rats were measured to evaluate the effects of fracture healing at 0, 2, 4, and 6th week. X-rays were taken every 3 week from 0 to 6th week to evaluate fracture healing effect. Results 1. No cytotoxicity was observed. 2. DPPH and ABTS radical scavenging activity were increased in a concentration dependent manner, indicating anti-oxidant effect. 3. NO, $IL-1{\beta}$, IL-6, and $TNF-{\alpha}$ were not significantly changed, indicating no anti-inflammatory effect. 4. Osteocalcin, Calcitonin, $TGF-{\beta}$ and ALP were significantly increased in the experimental groups. 5. CTX II, insulin were significantly decreased in the expermental groups. 6. Radiologic examination showed that union of fracture was promoted. Conclusions From above results, JGS showed significant results in factors related with fracture healing and radiologic examination. Threfore, JGS is expected to be effective in the treatment of fracture.

• 정보처리학회논문지A
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• 제18A권2호
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• pp.39-44
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• 2011

본 논문은 통합 비디오 코덱에 적용할 수 있는 DCT와 양자화 회로에 대한 고성능 구조를 제안한다. 제안된 구조는 JPEG, MPEG-1/2/4, H.264, VC-1과 같은 동영상 압축 표준들에 사용되는 모든 변환과 양자화에 적용할 수 있다. 통합 DCT 회로 구조를 위해 8x8 DCT의 변환행렬을 재배치하는 순열행렬을 정의하였고 $4{\times}4$ DCT의 변환행렬과 통합하기 위해 $8{\times}8$ 변환행렬을 4개의 $4{\times}4$ 변환행렬로 나누었다. $8{\times}8$ DCT는 재배치와 분할된 변환행렬을 기반으로 $4{\times}4$ DCT 연산을 반복하여 수행된다. 구현된 회로는 사용자가 변환 계수를 입력하기 때문에 앞으로 등장할 어떤 종류의 DCT 변환에도 매우 쉽게 확장할 수 있다. DCT 회로의 곱셈기들은 회로 크기를 최소화하기 위해 양자화 회로에서 사용되는 곱셈기들과 공유하였다. 이때, 양자화 회로는 회로 구현에 필요한 자원과 처리 시간의 증가 없이 DCT 회로와 통합된다. 제안된 DCT와 양자화 회로는 RTL로 구현하였고 FPGA가 탑재된 보드에서 동작을 검증하였다.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제38권
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• pp.29.1-29.9
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• 2016

Background: The objective of this study was to evaluate xenograft degradation velocity when treated with 4-hexylresorcinol (4HR). Methods: The scapula of a cow was purchased from a local grocery, and discs (diameter 8 mm, thickness 1 mm) were prepared by trephine bur. Discs treated with 4HR were used as the experimental group. Untreated discs were used as the control. X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FT-IR), antibacterial test, endotoxin test, and scanning electron microscopy (SEM) were performed on the discs. In vivo degradation was evaluated by the rat calvarial defect model. Results: The XRD and FT-IR results demonstrated successful incorporation of 4HR into the bovine bone. The experimental disc showed antibacterial properties. The endotoxin test yielded results below the level of endotoxin contamination. In the SEM exam, the surface of the experimental group showed needle-shaped crystal and spreading of RAW264.7 cells. In the animal experiments, the amount of residual graft was significantly smaller in the experimental group compared to the control group (P = 0.003). Conclusions: In this study, 4HR was successfully incorporated into bovine bone, and 4HR-incorporated bovine bone had antibacterial properties. In vivo experiments demonstrated that 4HR-incorporated bovine bone showed more rapid degradation than untreated bovine bone.

• Journal of Korean Neurosurgical Society
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• 제43권6호
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• pp.259-264
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• 2008

Objective : Total laminectomy (TL) is an effective surgical technique for the treatment of cervical ossification of the posterior longitudinal ligament (OPLL) along multiple levels. However, kyphosis and probable neurological deterioration have been frequently reported after laminectomy. We analyzed the changes in the cervical curvature after TL and subsequent changes in neurological status. Methods : We retrospectively reviewed the records of 14 patients who underwent TL for the treatment of cervical OPLL between Jan. 1998 and Dec. 2003. TL was selected according to the previously determined criteria. The curvature of the cervical spine was visualized on a lateral cervical spine X-ray and measured using Ishihara's Curvature Index (CI) before the operation and at the last follow-up examination. Perioperative neurological status was estimated using the modified Japanese Orthopedic Association score and the Improvement Rate (IR) at the same time as the images were evaluated. Results : The mean age of the patients was 57 years, the male/female ratio was 10:4, and the mean follow-up period was 41 months. The mean number of OPLL was 4.9, and the mean number of operated levels was also 4.9. The CI decreased after TL (p=0002), which was indicative of a kyphotic change. However, this kyphotic change showed no correlation with the length of the follow-up period, number of operated levels and preoperative CI. Neurological examination at the last follow-up showed an improved neurological status in all patients (p=0.001). There was no neurological deterioration in any case during the follow-up period. Moreover, there was no correlation between IR and the degree of kyphotic change. Postoperative complications, such as C5 radiculopathy and epidural bleeding, resolved spontaneously without neurological sequelae. Conclusion : Kyphotic change was observed in all but one patient who underwent TL for the treatment of cervical OPLL. However, we did not find any contributing factors to kyphosis or evidence of postoperative neurological deterioration.

• 한국균학회지
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• 제26권2호통권85호
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• pp.256-264
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• 1998

한국에서 자생하고 소나무와 외생균근을 갖는 송이에 대한 18S ribosmal DNA의 DNA 서열을 조사하였다. 4개의 지역에서 채집된 송이의 514 bp 분석결과 18S rDNA의 서열는 모두 동일하였고, 경북대학교 미생물연구실의 연구 결과와는 4 bp가 차이가 나타났다. NCBI의 BLAST search결과, T. matstake와 제일 유사한 것으로 나타났다. 분석된 514 bp의 서열비교에서는 다른 버섯균과 차이가 있는 서얼 부분을 파악하였다. 또한, 이러한 자료를 이용하여 유사도 분석에서 각각의 속에 속하는 균들은 같은 묶음을 나타내고 있으나, 과 혹은 그 이상의 단위에서의 비교는 좋은 결과가 나오지 않았다. 본 연구를 통해 외생균근의 확인 작업에 필요한 primer 제작을 위한 사전 자료를 얻었으며, 또한 조사된 염기서열도 분석할 수 있었다.

• 재활간호학회지
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• 제4권2호
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• pp.251-264
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• 2001

The purpose of study was to compare body image between diabetes mellitus patients who used insulin pump therapy and didn't use insulin pump therapy. The study design was comparative survey study the subjects were 60 diabetes mellitus patients who used insulin pump therapy and 60 diabetes mellitus patients who didn't use insulin pump therapy at B hospital in Busan. The data were collected from 15th April to 20th August, 1998. The instrument used for this study were Osgood's body image scale. The collected data were analyzed frequency, percentage, $X^2$-test, mean, standard deviation, t-test, ANOVA, Scheffe test. The results were as follows 1. Demographical characteristics between diabetes mellitus patients who used insulin pump therapy and didn't use insulin pump therapy were no significant difference. 2. Characteristics related disease between diabetes mellitus patients who used insulin pump therapy and didn't use insulin pump therapy were significant difference in paticipation of D.M. meeting, no of paticipation of D.M. meeting. 3. Body inmage score of diabetes mellitus patients was $69.08{\pm}18.13$. In body image, diabetes mellitus patients who used insulin pump therapy were higher than that didn't use insulin pump therapy(t=1.964, P<.05) 4. In body image's each item, common-strange item, noble-humble item, competent-incompetent item, light-heavy item, diabetes mellitus patients who used insulin pump therapy were higher than diabetes mellitus patients who didn't use insulin pump therapy(P<.05). 5. In body image according to economic status, marital status, occupational status were significantly difference. 6. In body image according to causes of regular hospital visiting, paticipation of diabetes mellitus class were significantly difference. In conclusion, diabetes mellitus patients who used insulin pump therapy were more positive than diabetes mellitus patients who didn't use insulin pump therapy.

• 약학회지
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• 제38권3호
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• pp.250-264
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• 1994

Omeprazole(OMZ)-cholestyramine(CHL) and various OMZ-Dowex resin complexes were prepared by reaction between OMZ and activated resins in 0.1N NaOH solution. And their physical properties were tested by means of infrared(IR), differential scaning caloimeter(DSC), X-ray diffraction. Chemical stability of OMZ-CHL was increased markedly compared with OMZ and the decomposition of OMZ-CHL followed the pseudo first-order kinetics and the rate constants were $2.743{\times}10^{-4}/day$ at $20^{\circ}C$, $7.83{\times}10^{-3}day^{-1}$ under 80% RH and $1.68{\times}10^{-2}day^{-1}$ under UV radiation, respectively. On the other hand, the rate constants of OMZ were $2.996{\times}10^{-4}day^{-1}$ at $20^{\circ}C$, $1.17{\times}10^{-2}day^{-1}$ under 85% RH, and $4.07{\times}10^{-2}day^{-1}$ under UV radiation, respectively. The rates of dissolution of OMZ-CHL bulk and OMZ-CHL tablet were 100% and more than 85% in 15 minutes, respectively, which were increased than OMZ base and OMZ-tablet. In the acute toxicological test, the value of oral $LD_{50}$(mouse) was 4.608 g/kg. OMZ-CHL was pelletized using lactose, polyethyle neglycol(PEG), D-sorbitol, Avicel PH 101, sodium laurylsulfate and polyvinylpyrrolidone(PVP) K-30, and enteric coated with HPMCP, Myvacet, acetone, ethanol and cetanol, of which dissolution rate was found to be more than 85% in 10 minutes. From the above results, it was found that OMZ-CHL is a useful means for development of new oral dosage forms of OMZ.

• 대한치과기공학회지
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• 제32권3호
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• pp.255-264
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• 2010

Purpose: This study was conducted to corroborate factors affecting dental technicians recognition states of their job consciousness. Methods: Self-administering questionnaires were distributed directly to some 200 registered female dental technicians in metropolis, small & medium-sized cities, farming and fishing villages of whom 153(76.5%) female dental technicians and female students responded in December, 2009. Information on recognition states of female dental technicians and female students in department of dental technology possible occupational mind and other general characteristics was gathered. Analysis of data was processed by use of X2-test and multiple regression analysis. Results: The recognition states of occupational satisfaction were higher in female students than female dental technicians(p<.05). They were observed that between respondents with more than five years of work and less than five years of career(p<.05). Statistically significant differences were observed in recognition values of female dental technicians occupational satisfaction between high and low groups of internal characteristic of their position and all ceramic part(p<.05). Conclusion: For woman dental technicians, the most predictive variables for recognition values of occupational satisfaction were an age, between groups, which of part and career(p<.05). Finally, this result suggests the facts that in order to achieve self-realization through the work experience, women herself should get rid of the dichotomous diagram and should change the consciousness of traditional role normals.

• Tribology and Lubricants
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• 제32권5호
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• pp.141-146
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• 2016

The diketopyrrolopyrrole (DPP) pigment is a bicyclic 8-π-electron system containing two lactam units. Typical DPP derivative pigments have melting points of over 350°C and very low solubility in most solvents, and show absorption in the visible region with a molar extinction coefficient of 33,000 dm²mol⁻¹ and strong photoluminescence with maxima in the range 500–600 nm. X-ray structure analyses of DPP show that the whole molecule is almost in one plane. The phenyl rings are twisted out of the heterocyclic plane and the intermolecular hydrogen bonding between neighboring lactam NH and carbonyl units influences the structure of the DPP pigment in the solid state. In this study, mono-N-alkylation and mono-N-arylation were undertaken for Pigment Red 264 or Pigment Orange 73 with alkyl halide and aryl halide, respectively, in the presence of sodium tert-butoxide as a base catalyst to improve the solubility of DPP pigments and their application as CO₂ indicators. The synthetic yield was in the range 11–88%. The indicator dyes are highly soluble in organic solvents and shows pH-dependent absorption (λ_max 501 and 572 nm for the protonated and deprotonated forms, respectively) and emission (λ_max 524 and 605 nm for the protonated and deprotonated forms, respectively) spectra. The mono-N-alkylated and mono-N-arylated DPP pigment was identified by ¹H-NMR (¹H-Nuclear Magnetic Resonance Spectrometer), FT-IR (Fourier Transform Infrared Spectroscopy), and MS (Mass Spectrometry). According to the results of color and hue properties obtained by a color matching analyzer, the synthesized DPP pigment material can be used as a CO₂ indicator.

• 한국방송∙미디어공학회:학술대회논문집
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• 한국방송공학회 2011년도 추계학술대회
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• pp.172-175
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• 2011

높은 효율을 가진 비디오 압축 코덱인 H.264/AVC는 예전보다 압축 성능을 향상 시키기 위한 방법 중 하나로 율-왜곡 최적화 기법이라는 것을 사용한다. 이 기법은 압축된 결과를 가지고 손실과 압축률 두 가지를 모두 고려하여 어떤 경우가 더 최적의 압축인가 하는 것을 판별하는데, 여기서 모든 경우에 대해 압축을 수행해야 함으로 이전 보다 몇 배나 높은 복잡도를 가질 수 밖에 없다. 이러한 문제를 해결하고자 하는 노력으로 본 논문에서는 SAHTD(Sum of Absolute Hadamard Transform Difference)라는 기준을 사용하여 이를 이용해 율-왜곡 최적화 기법을 사용하지 않거나, 사용을 최소화 하면서 압축 효율을 유지하는 방법을 제시하였다. 본 논문에서는 휘도 신호 $8{\times}$8과 $4{\times}4$블록을 위한 방법을 제시하고 있다. 이 두 가지 크기의 블록에 대해서 SAHTD값을 구해 SAHTD가 낮은 순으로 모드들을 정렬하고, 이것이 가장 낮은 3개의 모드를 선택해 이것 중에 MPM이 포함되지 않았을 경우에 대해서는 MPM을 포함해 4개의 모드를 선택해 압축을 수행하도록 한다. 여기서 얻은 모드들 중에 SAHTD값이 일정 값 이상 더 낮은 모드가 존재할 경우, 그 모드들에 대해서만 율-왜곡 최적화 기법을 수행한다. 이를 통해 최적의 모드일 가능성이 낮은 모드들에 대한 부가적인 연산 수행을 방지하게 된다. 휘도신호 16x16이나 색차 신호 압축의 경우에는 SAHTD를 사용하여 가장 낮은 SAHTD값을 갖는 모드를 최적의 모드로 결정한다. JM 참조 소프트웨어를 통한 실험결과 제안된 기법은 기존 JM의 방식에 비해 화면 내 프레임의 부호화 시간의 82.2% 감소와 0.042dB의 PSNR 감소율, 0.527%의 비트 증가율을 보여주었다.