• Asian Pacific Journal of Cancer Prevention
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• v.17 no.4
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• pp.2291-2295
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• 2016

Small molecule tyrosine kinase inhibitors targeting HER 2 receptors have emerged as an important therapeutic approach in inhibition of downstream proliferation and survival signals for the treatment of breast cancers. Recent drug discovery efforts have demonstrated that naturally occurring polyphenolic compounds like delphinidin have potential to inhibit proliferation and promote apoptosis of breast cancer cells by targeting HER2 receptors. While delphinidin may thus reduce tumour size, it is associated with serious side effects like dysphonia. Owing to the narrow therapeutic window of delphinidin, the present study aimed to identify high affinity compounds targeting HER2 with safer pharmacological profiles than delphinidin through virtual screening approaches. Delphinidin served as the query parent for identification of structurally similar compounds by Tanimoto-based similarity searching with a threshold of 95% against the PubChem database. The compounds retrieved were further subjected to Lipinski and Verber's filters to obtain drug like agents, then further filtered by diversity based screens with a cut off of 0.6. The compound with Pubchem ID: 91596862 was identified to have higher affinity than its parent. In addition it also proved to be non-toxic with a better ADMET profile and higher kinase activity. The compound identified in the study can be put to further in vitro drug testing to complement the present study.

• The Journal of the Korea Contents Association
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• v.13 no.9
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• pp.216-226
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• 2013

This study is conducted to verify the effect on the job performance mediating job satisfaction of participant's self-leadership and empowerment for Senior Employment Programs. The questionnaire research targets, a total of 158, are used analysis on participants for Senior Employment Programs in Gwang-ju, Jeollanam-do, Jeollabuk-do, Jeju. In order to derive research result to use a SPSS Version 12.0 for Window program, and factorial analysis, reliability verification for each variable were used. Additionally, It was used to carry out hypothesis verification for Regression analysis. As a result, the study shows that the job performance is maximized by the mediation effect of job satisfaction with self-leadership and empowerment of participants on Senior Employment Programs. On the base of study result, this paper suggest for participants in Senior Employment Program to enforce method about Natural Reward Strategies, Meaning, Confidence, Impact.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.2
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• pp.511-519
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• 2016

The purpose of this study was to examine the effects of motivation for the selection of major and satisfaction in the major on the adaption of university life among university students and to present basic data to assist in the healthy adaption of university life. A survey was given to university students in Seoul and Chungcheong cities from October 13 to October 27, 2015 of 250 copies of the questionnaire distributed, a total of 242 copies were in the final analysis. For data analysis, SPSS 21.0 for Windows was used. As a result, there were correlations among the variables, the adaption of University life of university students was affected by the personal motivation, social motivation for the selection of major with the largest effect being class satisfaction. The explanatory power was 38%. In conclusion, it is important to develop teaching and learning programs and counselling students considering class satisfaction for improving the adaption to university life.

• Korean Journal of Veterinary Research
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• v.39 no.4
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• pp.738-742
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• 1999

The objective of this experiment was to investigate the effect of Newcastle disease virus (NDV) and infectious bursal disease virus (IBDV) vaccination on performance of broiler chicks for five weeks. Two types of poultry houses and three patterns of vaccination ($NDV^-/IBDV^-$, $NDV^+/IBDV^-$ and $NDV^+/IBDV^+$) were factorially assigned to six treatments. NDV, B1 strain and IBDV, Bursin-2 vaccine were orally administered at 5, 14 and 7, 18 days, respectively. Forty eight hundred chicks were grouped into four replications with two hundnyd hybro $\times$ hybro chicks per each treatment. Weight gain, feed conversion ratio (FCR), mortality and product index were surveyed at the end of experiment. Bursa index and IBDV antibody titer of chicks were weekly measured. Weight gain of chicks vaccinated with $NDV^+/IBDV^+$ was significantly increased compared to that of other treatments at both window and windowless poultry houses (p<0.05). Chicks vaccinated with $NDV^+/IBDV^+$ also showed significantly improving the FCR and mortality compared to those of other treatments at both poultry houses (p<0.05). The bursa indecies of both poultry houses were high from one-day- to three-weeks-old, but were low for the rest of two weeks. IBDV antibody of all chicks was detected 100% by agar gel precipitation (AGP) test at one day old, but was not detected in $NDV^-/IBDV^-$ and $NDV^+/IBDV^-$ treatments at four weeks old. However, it showed 100% in $NDV^+/IBDV^+$ treatment. Antibody titer using ELISA showed similar trend to that of AGP test. The results of this experiment confirmed that IBDV and NDV combined vaccine significantly improved the performance of broiler chicks.

• Journal of the Korean Society of Clothing and Textiles
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• v.40 no.1
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• pp.131-147
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• 2016

This study investigated the relationship between fashion behavior, impression management behavior, and career success. A conceptual model and hypotheses were established based on theoretical linkages between the constructs. Thereafter, empirical data were collected using a set of questionnaires. For this reason, the sample was taken from 720 office workers' who worked at 14's Korea Enterprise, 697 of which was used for an empirical analysis (sample: men over 30 years of age and more than three years continuous service). This study conducted an exploratory factor analysis and confirmatory factor analysis for the validity test. Cronbach's alpha test is used for the reliability test. Moreover, PLS structural equation modeling (SEM) was employed to test hypothesized relationships in the conceptual model (SPSS 20.0 window/Smart PLS 3.0). This study shows that the proposed model is reasonably fit to the actual data. The following results were obtained from the analyses. First, fashion behavior and impression management behavior is positively related to career success. The result shows that economics of the fashion behaviors sub-types were statistically more significant to influence career success. The self-focused of the impression management behavior sub-types were more than statistically significant to influence career success. This finding has great implications to understand self-management behavior and the career success of male office workers.

• Proceedings of the Korean Vacuum Society Conference
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• 2011.02a
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• pp.210-210
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• 2011

The effects of CH2F2 and N2 gas flow rates on the etch selectivity of silicon nitride (Si3N4) layers to extreme ultra-violet (EUV) resist and the variation of the line edge roughness (LER) of the EUV resist and Si3N4 pattern were investigated during etching of a Si3N4/EUV resist structure in dual-frequency superimposed CH2F2/N2/Ar capacitive coupled plasmas (DFS-CCP). The flow rates of CH2F2 and N2 gases played a critical role in determining the process window for ultra-high etch selectivity of Si3N4/EUV resist due to disproportionate changes in the degree of polymerization on the Si3N4 and EUV resist surfaces. Increasing the CH2F2 flow rate resulted in a smaller steady state CHxFy thickness on the Si3N4 and, in turn, enhanced the Si3N4 etch rate due to enhanced SiF4 formation, while a CHxFy layer was deposited on the EUV resist surface protecting the resist under certain N2 flow conditions. The LER values of the etched resist tended to increase at higher CH2F2 flow rates compared to the lower CH2F2 flow rates that resulted from the increased degree of polymerization.

• Journal of Korean society of Dental Hygiene
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• v.13 no.1
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• pp.146-157
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• 2013

Objectives : The purpose of this paper is to analyze the effects of short-term oral health care on children at community care centers, in order to allow them to maintain good oral health. Methods : The SPSS (Statistical Package for Social Science), Window Version 18.0 was used to analyze the data for the children's present conditions of oral health; their ability to maintain good oral health; their general knowledge about oral health; changes in their oral health awareness; habit formations concerning oral health; and the satisfaction level of oral health education. Results : 1. While the average number of teeth before the program is 19.84(6.19), that of teeth after the program is 21.33(6.10). 2. Average test scores on oral health information of post-program are improved more than those of pre-program. 3. The 8th measurement of O'Leary plaque index is 3.27, which shows significant changes. 4. Satisfaction level with the program is 4.75(0.45), which shows that children are satisfied with the program. Conclusions : The paper shows that in order to maintain the oral health of children at community care centers, their habit formation and practice for the oral health is important. It also shows that cooperation among communities and public health centers is important to develop various oral health education programs like the program.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.4
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• pp.2511-2519
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• 2015

This research was executed to develop a consultation program for female victims of domestic violence in the past and appraise its effectiveness. For the research, we selected 30 persons for an experimental group and a control group respectively, and practiced frequency analysis, reliability analysis, homogeneity check and T-test of independent sample by using SPSS 20.0 for Windows. The result of analysis is as follows. First, it was probed that the consultation program had the effect to improve the self-esteem of female victims of domestic violence, and reduce depression levels and anxiety. Second, it appeared that consultation program improved the psychological and social adaptation of female victims of domestic violence positively and cast an affirmative effect on the satisfaction of communication of subdivision and conflict-coping method. Therefore, it app[eared that this program had a close relation with the attitude etc. to solve the issues of interpersonal relations and communication of female victims of domestic violence. That is, it was verified that the program had the effect in that they escaped from the sequela of abuse and adapted themselves to mental society.

• Journal of The Korean Society of Integrative Medicine
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• v.4 no.2
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• pp.23-28
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• 2016

Purpose : The purpose of this study was to investigate the effects of transverse abdominal muscle contraction on pulmonary function in supine position. Methods : 10 female and 10 male college students were recruited this study. Pulmonary Function test was measured with QUARK SPIRO. To check the changes in lung function with transverse abdominal muscle contraction, we tested pulmonary function in the supine, with and without transverse abdominal muscle contraction. While the transverse abdominis was activating, we investigate in the change of forced expiration. All statistical analyses were performed using SPSS Statistics VER.12.0 for window version p-values less than 0.05 were used to identify significant differences. Statistical analysis was used Paired t-test to know difference between activated and non-activated TrA of forced expiration. Results : The subject with transverse abdominal muscle contraction showed significant increments in variable of FVC, FEV1, PEF compared to the pre-intervention results (p<0.01). Conclusion : These results indicate that spontaneous contraction of the TrA helps pulmonary function. And the selective contraction of the transverse abdominis at the end of forced inspiration makes increases in the lung capacity.

• The Journal of Korean Academic Society of Nursing Education
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• v.7 no.2
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• pp.254-263
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• 2001

The Purpose of this study was to find out the effects of education for prevention of sexual abuse (rape, sexual assault, sexual harassment etc.) of children in kindergarten teachers. Incidences of sexual abuse in Korea is ranked 3rd in the world. Sexual abuse of children, particularly, is one of the most serious crimes that affect both the victimized children and their family. The issue related to sexual abuse of children has been ignored, and there is a lack of systematic education to prevent sexual abuse of children either for children or their parents in Korea. Furthermore, lack of knowledge and poor attitude of teachers limit their capability to provide education for sexual abuse prevention to the children. The education for kindergarten teachers may change their knowledge of the sexual abuse and their attitude toward it and improve their capability in helping children. 114 Korean kindergarten teachers participated in this study. Research design was one group pretest-posttest design. The education given to the subjects included 2 hours of lecture. The education program was developed based on a survey. Preschool-aged-children, parents, and teachers were interviewed to reveal their educational needs based on their experiences related to sexual abuse. This program includes such as safety education, crisis management, resource person(s), and phone numbers of available hospital. Data was collected before and after the education was given to the subjects, to assess their knowledge and attitude toward child sexual abuse. Two instruments were used in this study. Using Cronbach's ALPHA validity and reliability of 2 instruments were tested. The analysis of the data was done with Window SPSS 10.0 for descriptive statistics, t-test and ANOVA. The results of this analysis were as follows : 1. After education, the score of kindergarten teachers knowledge was higher than before (t=-4.409, p=0.002). 2. After education, the score of kindergarten teachers attitude was higher than before (t=3.065, p=0.003). The findings from this study will provide an intervention strategy for prevention of sexual abuse in children.