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Bioinformatics and Genomic Medicine (생명정보학과 유전체의학)

  • Kim, Ju-Han
    • Journal of Preventive Medicine and Public Health
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    • v.35 no.2
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    • pp.83-91
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    • 2002
  • Bioinformatics is a rapidly emerging field of biomedical research. A flood of large-scale genomic and postgenomic data means that many of the challenges in biomedical research are now challenges in computational sciences. Clinical informatics has long developed methodologies to improve biomedical research and clinical care by integrating experimental and clinical information systems. The informatics revolutions both in bioinformatics and clinical informatics will eventually change the current practice of medicine, including diagnostics, therapeutics, and prognostics. Postgenome informatics, powered by high throughput technologies and genomic-scale databases, is likely to transform our biomedical understanding forever much the same way that biochemistry did a generation ago. The paper describes how these technologies will impact biomedical research and clinical care, emphasizing recent advances in biochip-based functional genomics and proteomics. Basic data preprocessing with normalization, primary pattern analysis, and machine learning algorithms will be presented. Use of integrated biochip informatics technologies, text mining of factual and literature databases, and integrated management of biomolecular databases will be discussed. Each step will be given with real examples in the context of clinical relevance. Issues of linking molecular genotype and clinical phenotype information will be discussed.

Innovative Nuclear Power Plant Building Arrangement in Consideration of Decommissioning

  • Choi, Won-Jun;Roh, Myung-Sub;Kim, Chang-Lak
    • Nuclear Engineering and Technology
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    • v.49 no.3
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    • pp.525-533
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    • 2017
  • A new concept termed the Innovative Nuclear Power Plant Building Arrangement (INBA) strategy is a new nuclear power plant building arrangement method which encompasses upfront consideration of more efficient decommissioning. Although existing decommissioning strategies such as immediate dismantling and differed dismantling has the advantage of either early site restoration or radioactive decommissioning waste reduction, the INBA strategy has the advantages of both strategies. In this research paper, the concept and the implementation method of the INBA strategy will be described. Two primary benefits will be further described: (1) early site restoration; and (2) radioactive waste reduction. Several other potential benefits will also be identified. For the estimation of economic benefit, the INBA strategy, with two primary benefits, will be compared with the immediate dismantling strategy. The effect of a short life cycle nuclear power plant in combination with the INBA strategy will be reviewed. Finally, some of the major impediments to the realization of this strategy will be discussed.

Using Highly Secure Data Encryption Method for Text File Cryptography

  • Abu-Faraj, Mua'ad M.;Alqadi, Ziad A.
    • International Journal of Computer Science & Network Security
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    • v.21 no.12
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    • pp.53-60
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    • 2021
  • Many standard methods are used for secret text files and secrete short messages cryptography, these methods are efficient when the text to be encrypted is small, and the efficiency will rapidly decrease when increasing the text size, also these methods sometimes have a low level of security, this level will depend on the PK length and sometimes it may be hacked. In this paper, a new method will be introduced to improve the data protection level by using a changeable secrete speech file to generate PK. Highly Secure Data Encryption (HSDE) method will be implemented and tested for data quality levels to ensure that the HSDE destroys the data in the encryption phase, and recover the original data in the decryption phase. Some standard methods of data cryptography will be implemented; comparisons will be done to justify the enhancements provided by the proposed method.

ON SOME GENERALIZATIONS OF THE REVERSIBILITY IN NONUNITAL RINGS

  • Hryniewicka, Malgorzata Elzbieta;Jastrzebska, Malgorzata
    • Journal of the Korean Mathematical Society
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    • v.56 no.2
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    • pp.289-309
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    • 2019
  • This paper is intended as a discussion of some generalizations of the notion of a reversible ring, which may be obtained by the restriction of the zero commutative property from the whole ring to some of its subsets. By the INCZ property we will mean the commutativity of idempotent elements of a ring with its nilpotent elements at zero, and by ICZ property we will mean the commutativity of idempotent elements of a ring at zero. We will prove that the INCZ property is equivalent to the abelianity even for nonunital rings. Thus the INCZ property implies the ICZ property. Under the assumption on the existence of unit, also the ICZ property implies the INCZ property. As we will see, in the case of nonunital rings, there are a few classes of rings separating the class of INCZ rings from the class of ICZ rings. We will prove that the classes of rings, that will be discussed in this note, are closed under extending to the rings of polynomials and formal power series.

Customer Focused eBusiness

  • Ran, Im-Yeong
    • Proceedings of the Korea Database Society Conference
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    • 2001.11a
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    • pp.150-195
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    • 2001
  • Only 4% of all customers with problems complain average customer with a problem will: - Tell 7-10 people - Those people will tell another 5-7 - Those people will tell another 3-5 (omitted)

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The Process of PBL Package Development (PBL 패캐지(Learning Package) 개발절차 모형에 관한 연구)

  • Lee, Woo-Sook;Park, Mee-Young
    • The Journal of Korean Academic Society of Nursing Education
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    • v.7 no.1
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    • pp.126-142
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    • 2001
  • Although a call for the implementation of PBL in nursing education is getting increased, it has not been actively implemented as it could be. The main reason for this situation seems to be the lack of well designed learning packages. Well designed PBL packages can be the core factor for the successful implementation of PBL. However, this seems to be the hardest task for teachers wanting to implement PBL. Therefore, the purpose of this study is to develop a systematic framework of PBL package development process and provide the examples of its application. This framework of the process of PBL package development includes thirteen steps. First of all, the team needs to decide a topic to be explored in the package and then clusters concepts related to the topic. Second, the team selects a real situation and writes it as a story. Third, knowledge, skills, and attitudes that practitioners need to know to deal with the situation will be explored. Fourth, learning objectives will be written. The next, the team will check if the situation includes multidisciplinary concepts and content. Sixth, the story will be divided into several parts. Seventh, part 1 will be written. Eighth, clinical documents related to part 1 need to be prepared. Ninth, the team will write a suggested approach for students. Then, they need to prepare a tutor's guide for part 1. Eleventh, the team will prepare a list of reading materials and plan for lectures and clinical laboratory sessions. Twelfth, they will write part 2 ~ part N following the steps from the seventh to the eleventh. The last step is evaluating the package and amending it as needed. These thirteen steps are very detailed and easy to follow for beginners. It is expected that this framework will contribute to accelerate the implementation of PBL in nursing education.

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Comprehensive evaluation of structural geometrical nonlinear solution techniques Part II: Comparing efficiencies of the methods

  • Rezaiee-Pajand, M.;Ghalishooyan, M.;Salehi-Ahmadabad, M.
    • Structural Engineering and Mechanics
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    • v.48 no.6
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    • pp.879-914
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    • 2013
  • In part I of the article, formulation and characteristics of the several well-known structural geometrical nonlinear solution techniques were studied. In the present paper, the efficiencies and capabilities of residual load minimization, normal plane, updated normal plane, cylindrical arc length, work control, residual displacement minimization, generalized displacement control and modified normal flow will be evaluated. To achieve this goal, a comprehensive comparison of these solution methods will be performed. Due to limit page of the article, only the findings of 17 numerical problems, including 2-D and 3-D trusses, 2-D and 3-D frames, and shells, will be presented. Performance of the solution strategies will be considered by doing more than 12500 nonlinear analyses, and conclusions will be drawn based on the outcomes. Most of the mentioned structures have complex nonlinear behavior, including load limit and snap-back points. In this investigation, criteria like number of diverged and complete analyses, the ability of passing load limit and snap-back points, the total number of steps and analysis iterations, the analysis running time and divergence points will be examined. Numerical properties of each problem, like, maximum allowed iteration, divergence tolerance, maximum and minimum size of the load factor, load increment changes and the target point will be selected in such a way that comparison result to be highly reliable. Following this, capabilities and deficiencies of each solution technique will be surveyed in comparison with the other ones, and superior solution schemes will be introduced.

A Study on the Development of Computer Assisted Instruction for Definite Integral (정적분 단원에 관한 CAI프로그램 개발 연구)

  • 우제환
    • Journal of the Korean School Mathematics Society
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    • v.1 no.1
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    • pp.97-109
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    • 1998
  • The activities of teaching and learning are to try to reach the lesson object most closely in many ways. Considering that the lesson objects are to get the principle or law of a concept, to acquire the mathematical function, to master it through repeated exercises and to solve mathematical problems, we need many ways to reach such objects. Among the many ways, we can first think of one: the students will learn with curiosity and according to their own ability or advancing level in learning when teachers study and prepare necessary contents enough in advance by using computers, showing the right program to learners' needs. For example, defining definite integral by measuration by parts will help understand measuration by parts well and know the meaning of definite integral correctly, In teaching and learning by the use of this program, the educational effects are expected as follows. 1. It is thought that this program will stimulate the desire for and interest in learning because it used animation and acoustic effect. And voluntary and positive thinking activity will be shown. 2. It is expected that the conviction of formulas will be got and the concept of definite integral will be remembered firmly by showing how to measure the width of circle with the use of measuration by parts in various other ways instead of the ways used at present. 3. It is expected that students will feel the pleasure of mathematics in life when they recognize mathematical facts scattered really in our life rather than mathematical difficulties. 4. It is expected that the repeated review of programs already designed will remove the fear of incomplete parts and help review again. 5. It is certain that positive attitude in life will be formed as teacher-centered class is changed into learner-centered class and unwilling study is changed into self-oriented study. However, I think this program is insufficient for humanbeing-centered education given directly in contact with students on the ground of the variety in mathematical education and applications in many ways. And mechanically inhuman computers leave some solutions to be desired

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Relationship of Knowledge and Practical Will to Practice of Cancer Prevention Lifestyle by Late School-aged Children (학령기 후기 아동의 암 예방 생활습관 지식, 실천의지, 실천)

  • Cho, Mi-Hye;Kwon, In-Soo
    • Child Health Nursing Research
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    • v.16 no.4
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    • pp.259-267
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    • 2010
  • Purpose: This study was conducted to identify late school-aged children‘s knowledge, and practical will in the practice of cancer prevention lifestyle, and to examine the relations between these variables and factors that influence practice. Methods: The participants included 525 fifth and sixth grade students from 8 elementary schools in J and S cities. Data were collected in December 2008 using self-report questionnaires developed by the authors and were analyzed using the SPSS program. Results: Mean scores were, for knowledge of cancer prevention lifestyle, $0.76{\pm}0.11$ out of a possible 1, practical will, $4.05{\pm}0.55$ out of a possible 5, and practice, $3.66{\pm}0.41$ also out of 5. There were differences in knowledge (F=4.39, p=.013), practical will (F=18.35, p<.001), and practice (F=29.13, p<.001) according to academic achievement and in practical will (F=3.68, p<.001) and practice (F=3.01, p=.003) according to grade. There were positive correlations between knowledge and practical will (r=.205, p<.001), knowledge and practice (r=.181, p<.001), practical will and practice (r=.628, p<.001). Practice will and knowledge of cancer prevention lifestyle showed a significant influence on practice. Conclusion: Results of this study indicate that effective strategies should be developed to motivate the practical will for the practice of cancer prevention lifestyle during childhood.

Climate Change and Coping with Vulnerability of Agricultural Productivity (기후변화와 농업생산의 전망과 대책)

  • 윤성호;임정남;이정택;심교문;황규홍
    • Korean Journal of Agricultural and Forest Meteorology
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    • v.3 no.4
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    • pp.220-237
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    • 2001
  • Over the 20th century global temperature increase has been 0.6$^{\circ}C$. The globally averaged surface temperature is projected to increase by 1.4 to 5.8$^{\circ}C$ over the period 1990 to 2100. Nearly all land areas will have higher maximum temperature and minimum temperature, and fewer cold days and frost days. More intense precipitation events will take plate over many areas. Over most mid-latitude continental interiors will have increased summer continental drying and associated risk of drought. By 2100, if the annual surface temperature increase is 3.5$^{\circ}C$, we will have 15.9$^{\circ}C$ from 12.4$^{\circ}C$ at present. Also the annual precipitation will range 1,118-2,447 mm from 972-1,841 mm at present in Korea. Consequently the average crop periods for summer crops will be 250 days that prolonged 32 days than at present. In the case of gradual increase of global warming, an annual crop can be adapted to the changing climate through the selection of filial generations in breeding process. The perennial crops such as an apple should be shifted the chief producing place to northern or high latitude areas where below 13.5$^{\circ}C$ of the annual surface temperature. If global warming happens suddenly over the threshold atmospheric greenhouse gases, then all ecosystems will have tremendous disturbance. Agricultural land-use plan, which state that farmers decide what to plant, based on their climate-based advantages. Therefore, farmers will mitigate possible negative imparts associated with the climate change. The farmers will have application to use agricultural meteorological information system, and agricultural long-range weather forecast system for their agroecosystems management. The ideal types of crops under $CO_2$ increase and climate change conditions are considered that ecological characteristics need indispensable to accomplish the sustainable agriculture as the diversification of genetic resources from yield-oriented to biomass-oriented characteristics with higher potential of $CO_2$ absorption and primary production. In addition, a heat-and-cold tolerance, a pest resistance, an environmental adaptability, and production stability should be also incorporated collectively into integrated agroecosystem.

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