• Archives of Plastic Surgery
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• 제43권6호
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• pp.491-497
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• 2016

Background Hypertrophic scarring is a pathological condition that occurs after trauma or surgery. Angiogenesis occurs more often with hypertrophic scarring than with normotrophic scarring. The regulation of angiogenesis is one of the key factors in hypertrophic scar management. Vascular endothelial growth factor (VEGF) is an essential factor in the angiogenetic response. This study investigated whether decreasing the level of VEGF is effective for treating hypertrophic scarring. Methods Ten 8-week-old female New Zealand white rabbits were included. Four defects were created on each ear by using a 6-mm punch. Bevacizumab (Avastin, Roche Pharma, Basel, Switzerland) was administered in one ear and normal saline was administered in the other ear. Treatment was administered starting on day 2, every 2 days, until day 14. The levels of VEGF were measured using enzyme-linked immunosorbent assay on day 10 and histologic results were analyzed on day 40. Results Bevacizumab induced-defects showed less hypertrophic scarring when compared with the control group as measured by the scar elevation index (SEI) and loose collagen arrangement. The SEI in the experimental group was $1.89{\pm}0.13$, compared to $1.99{\pm}0.13$ in the control group (n=30, P=0.005). Additionally, the VEGF level was lower ($38.72{\pm}11.03pg$ vs. $82.50{\pm}21.64pg$, n=10, P=0.001) and fewer vessels existed ($8.58{\pm}0.76$ vs. $7.2{\pm}1.20$, n=10, P=0.007). Conclusions Preventing excessive angiogenesis is effective for preventing scar formation, especially with hypertrophic scarring. Although it is not an approach that is sufficient alone for the management of scarring, it may be one of several important strategies for scar treatment.

• 대한간호학회지
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• 제45권6호
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• pp.939-948
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• 2015

Purpose: An emerging trend in Asian higher education is English-medium instruction (EMI), which uses English as the primary instructional language. EMI prepares domestic students for international leadership; however, students report difficulty in learning, and educators have raised questions concerning the effectiveness of EMI. The flipped learning model (FLM), in which lecture and homework activities for a course are reversed, was applied to an English-medium course offered by a college of nursing in Korea. The aims of this study were to: 1) revise an existing English-medium nursing course using the FLM; 2) explore students' learning experiences and their acceptance of the FLM; and 3) identify key factors in the success of FLM. Methods: We used a descriptive, cross-sectional, mixed-methods design and the participants were students at one nursing school in Korea. A series of course development meetings with faculties from the nursing school and the center for teaching and learning were used to develop the course format and content. We conducted course evaluations using the Flipped Course Evaluation Questionnaire with open-ended questions and focus group interviews. Results: Students (N=75) in a 15-week nursing course responded to a survey after completing the course. Among them, seven students participated in one of two focus groups. Overall, students accepted and favored the flipped learning strategy, and indicated that the method enhanced lecture content and their understanding of it. Factors associated with effective instruction included structured monitoring systems and motivational environments. Conclusion: The FLM requires sufficient preparation to facilitate student motivation and maximize learning outcomes.

• 가정과삶의질연구
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• 제26권6호
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• pp.1-20
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• 2008

This study investigates the influences of factors such as type and degree of family leisure among parents with five day work weeks on adolescents' perceived family strengths. Its findings are based on questionnaires collected from 525 male and female parents of middle school students. Factor analysis and MANOVA were employed for data analysis and $Scheff{\acute{e}}$ tests for post-hoc analysis. The main findings were as follows. First, adolescents whose parents work five days a week were at a higher level than other adolescents in terms of finances, family ties, communication, and social ties. Second, there were no significant differences concerning adolescents' family strength by type of family leisure. Third, adolescents with more family leisure activities scored higher than others in the areas of manageable strengths, financial levels, family ties, communication, and family social ties. Fourth, among families following the five day working system, adolescents who had more family leisure activities scored higher than the others in regards to manageable strengths, financial levels, family ties, communication, and family social ties. Additionally, where adolescents thought they had fewer family leisure activities, family-oriented adolescents tended to be engaged in higher physical-activity-oriented and hobby-oriented activities in relation to manageable strengths, financial level, family ties, and communication and hobby-oriented adolescents engaged in higher than average amounts of physical-activity, strengthening family social ties in the process. Fifth, concerning families not adhering to the five day working system, adolescents who had more family leisure activities scored higher than others in terms of manageable strengths, financial levels, family ties, communication, and family social ties. As the above results indicate, family leisure activities appear to be a key factor influencing family strength. Therefore, further support should be extended toward developing new forms of family leisure and additional studies should be devoted to the subject.

• 대한핵의학회지
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• 제20권2호
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• pp.47-52
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• 1986

A noninvasive procedure for diagnosis and quantitation of right-to-left intracardiac shunts will enhance the management of patients with cyanotic congenital heart disease. This study describes an application of radionuclide (RN) angiocardiography for quantitation of right-to-left shunt amount. Gamma variate model was fitted to radionuclide data recorded over the carotid artery. Data analysis was performed retrospectively in 35 patients who underwent cardiac catheterization within a week from the day of RN angiocardiography. Thirty one of the patient had right-to-left shunts and 4 of them had left-to-right shunts. Both the radionuclide and Fick measurements correlated well (r=0.93, 0.93, 0.89, p<0.01 in each measurements). Therefore, RN angiocardiography data may be used for accurate calculation of right-to-left shunts in cyanotic congenital heart disease patients.

• 동의생리병리학회지
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• 제16권4호
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• pp.782-787
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• 2002

This study was carried out to investigate the protective effect of chitosan on lipid peroxidation and key lipid parameters in Sprague-Dawley rat (SO rat) accutely exposured to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Male SO rats received single intraperitoneal (ip) injection of TCDD (40 j.lg/kg), and were given diet containing 3 or 5% chitosan for 4 weeks from 1 week before TCDD treatment. The gain in body weight was less in group treated with TCDD than in CON group, while that of Ch/H+ TCDD group (5% chitosan diet) increased. The decrease in liver and testis weight caused by TCDD was prevented by high dietary intake of chitosan (5% chitosan). Serum (total cholesterol, triglyceride, HDL-C, and LDL-C) and liver lipid parameters (total lipid, total cholesterol, and triglyceride) were significantly elevated in TCDD-induced rats, but these parameters excluding HDL-C were significantly reduced in high dietary intake of chitosan (5% chitosan). These findings suggest that chitosan is believed to be a possible protective effect against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat.

• 한국토양비료학회지
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• 제45권6호
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• pp.1187-1193
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• 2012

Water control is mainly one of the key factors that can affect nitrous oxide ($N_2O$) emissions from soils. This study was undertaken to determine the effect of intermittent drainage compared to continuous flooding (conventional water regime) on $N_2O$ emission to global warming potential (GWP) with NPK (standard cultivation practice), NPK+Straw, and PK fertilizations. Nitrous oxide emission rates were collected twice a week using a closed chamber method. With continuous flooding, nitrogen (N) application increased $N_2O$ emission by 106.6% ($0.64kg\;ha^{-1}$ in NPK) with respect to the PK treatment ($0.31kg\;ha^{-1}$), and straw addition to NPK enhanced 148.3% of seasonal $N_2O$ flux ($0.77kg\;ha^{-1}$ in NPK+Straw). Although seasonal $N_2O$ emission slightly increased by 16.1-42.9% with intermittent irrigation, its seasonal $CH_4$ emission drastically reduced at 43.5-52.8% resulting in a lower GWP at 48.9-58.5% with respect to that of continuously flooded treatments ($4.51Mg\;CO_2\;ha^{-1}$, PK; $7.60Mg\;CO_2\;ha^{-1}$, NPK; $14.55Mg\;CO_2\;ha^{-1}$, NPK+Straw). Rice yield, at similar fertilization with the continuously-flooded rice field, was not affected by intermittent irrigation. Conclusively, intermittent irrigation can be very effective and a rational soil management strategy to mitigate GWP with considering rice productivity in a temperate paddy rice field like Korea.

• Journal of Microbiology and Biotechnology
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• 제30권7호
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• pp.1067-1071
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• 2020

To understand the formation of initial gut microbiota, three initial fecal samples were collected from two groups of two breast milk-fed (BM1) and seven formula milk-fed (FM1) infants, and the compositional changes in gut microbiota were determined using metagenomics. Compositional change analysis during week one showed that Bifidobacterium increased from the first to the third fecal samples in the BM1 group (1.3% to 35.1%), while Klebsiella and Serratia were detected in the third fecal sample of the FM1 group (4.4% and 34.2%, respectively), suggesting the beneficial effect of breast milk intake. To further understand the compositional changes during progression from infancy to childhood (i.e., from three weeks to five years of age), additional fecal samples were collected from four groups of two breast milk-fed infants (BM2), one formula milk-fed toddler (FM2), three weaning food-fed toddlers (WF), and three solid food-fed children (SF). Subsequent compositional change analysis and principal coordinates analysis (PCoA) revealed that the composition of the gut microbiota changed from an infant-like composition to an adult-like one in conjunction with dietary changes. Interestingly, overall gut microbiota composition analyses during the period of progression from infancy to childhood suggested increasing complexity of gut microbiota as well as emergence of a new species of bacteria capable of digesting complex carbohydrates in WF and SF groups, substantiating that diet type is a key factor in determining the composition of gut microbiota. Consequently, this study may be useful as a guide to understanding the development of initial gut microbiota based on diet.

• 한국콘텐츠학회논문지
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• 제20권7호
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• pp.352-367
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• 2020

이 연구는 한국과 일본 간 갈등 문제를 다룬 한국 언론 보도의 프레임 유형과 의미화 전략을 비판적으로 검토했다. 이를 위해 2018년 10월 한국 대법원의 강제징용 배상 판결, 2019년 7월 일본 정부의 수출 규제 결정, 2019년 8월 한국 정부의 지소미아 종료 결정 등 갈등의 중요한 분기점이 된 세 시점에서부터 각 일주일 동안 조선일보, 한겨레, KBS 3개 언론사의 기사에 대한 프레임 분석과 텍스트 분석을 실시했다. 연구 결과 사건의 발생과 결과를 중심으로 갈등을 단순 중계하는 피상적 보도가 많고 맥락을 심층적으로 분석하거나 대안을 제시하는 보도는 적었다는 점이 드러났다. 또한 한일 갈등 국면에서 언론이 과도한 민족주의에 경도될 것이라는 예상과 달리, 한국 언론의 핵심 문제로 지적되는 정파적 보도 행태가 강하게 드러났다. 이 연구는 언론이 국가적 비상 상황인 한일 갈등마저 정치적 이해관계를 위해 이용하는 정파적 보도 양태를 극복해야 신뢰를 회복할 수 있다고 주장하였다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume II
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• pp.570-573
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• 2006

College GIS and remote sensing education usually consists of commercial software packages implementations in the classroom. Computer programming is quite important when college graduates work in private or public sectors relevant with GIS and remote sensing implementations. The objective of this paper was to develop a valley management system which implements GIS and remote sensing as the key components for education. The Valley Authority is entitled with water resource protection for sustainable drinking water supply of the second largest city in Taiwan. The test area consists of three different government agencies, Forest Service, EPA, and Water Resource Agency. Materials were provided by the Valley Authority in ArcGIS file format. MapObjects have made the GIS development process much easier. Remote sensing with image manipulation functions were provided by computer programming with Visual Baisc.NET and Visual C#.NET. Attributes inquiry are performed by these two computer languages as well. ArcGIS and ArcPad are also used for simple GIS manipulations of the test area. Comparison between DIY and commercial GIS can be made by college students. Functions provided by the developed valley management system depending on how many map layers have been used and what types of MapObjects components have been used. Computer programming experience is not essential but can be helpful for a college student. The whole process is a step-by-step sequence which college students can modify to depict their capability in GIS and remote sensing. The development process has gone through one semester, three hours every week in 18 weeks. College students enrolled in this class entitled with GIS showed remarkable progresses both in GIS and remote sensing.

• Journal of Ginseng Research
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• 제33권1호
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• pp.59-64
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• 2009

$Ca^{2+}$ and calmodulin (CaM), a key $Ca^{2+}$ sensor in all eukaryotes, have been implicated for defense responses of plants. Eukaryotic CaM contains four structurally and functionally similar $Ca^{2+}$ domains named I, II, III and IV. Each $Ca^{2+}$ binding loop consists of 12 amino acid residues with ligands arranged spatially to satisfy the octahedral symmetry of $Ca^{2+}$ binding. To investigate the altered gene expression and the role of CaM in ginseng plant defense system, cDNA clone containing a CaM gene, designated PgCaM was isolated and sequenced from Panax ginseng. PgCaM, which has open reading frame of 450 nucleotides predicted to encode a precursor protein of 150 amino acid residues. Its sequence shows high homologies with a number of other CaMs, with more similarity to CaM of Daucus carota (AAQ63461). The expression of PgCaM in different P. ginseng organs was analyzed using real time PCR. The results showed that PgCaM expressed at different levels in young leaves, shoots, and roots of 3-week-old P. ginseng. In addition, the expressions of PgCaM under different abiotic stresses were analyzed at different time intervals.