Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Chitosan on the Lipid Metabolism in Treated 2,3,7,8-Tetrachlorodibenzo-p-dioxin in Rats

다이옥신 처리에 대한 키토산이 지질대사에 미치는 효과

  • Hwang Seock Yeon (Department of Clinical Pathology, Chungbuk National University Hospital) ;
  • Yang Jin Bae (College of Oriental Medicine, Taejon University) ;
  • Chang Cheoul Soo (Department of Clinical Pathology, Kimcheon Health Siences College) ;
  • Kim Tae Up (Department of Pathology, College of Oriental Medicine, Wonkwang University) ;
  • Lee Hyung Chul (Department of Pathology, College of Oriental Medicine, Wonkwang University)
  • 황석연 (충북대학교병원 임상병리과) ;
  • 양진배 (대전대학교 한의과대학) ;
  • 장철수 (김천대학 임상병리과) ;
  • 김태업 (원광대학교 한의과대학 병리학교실) ;
  • 이형철 (원광대학교 한의과대학 병리학교실)
  • Published : 2002.08.01
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Abstract

This study was carried out to investigate the protective effect of chitosan on lipid peroxidation and key lipid parameters in Sprague-Dawley rat (SO rat) accutely exposured to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Male SO rats received single intraperitoneal (ip) injection of TCDD (40 j.lg/kg), and were given diet containing 3 or 5% chitosan for 4 weeks from 1 week before TCDD treatment. The gain in body weight was less in group treated with TCDD than in CON group, while that of Ch/H+ TCDD group (5% chitosan diet) increased. The decrease in liver and testis weight caused by TCDD was prevented by high dietary intake of chitosan (5% chitosan). Serum (total cholesterol, triglyceride, HDL-C, and LDL-C) and liver lipid parameters (total lipid, total cholesterol, and triglyceride) were significantly elevated in TCDD-induced rats, but these parameters excluding HDL-C were significantly reduced in high dietary intake of chitosan (5% chitosan). These findings suggest that chitosan is believed to be a possible protective effect against 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in rat.

Keywords

References

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