• Parasites, Hosts and Diseases
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• v.54 no.2
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• pp.147-154
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• 2016

Toxoplasma gondii infection induces alteration of the host cell cycle and cell proliferation. These changes are not only seen in directly invaded host cells but also in neighboring cells. We tried to identify whether this alteration can be mediated by exosomes secreted by T. gondii-infected host cells. L6 cells, a rat myoblast cell line, and RH strain of T. gondii were selected for this study. L6 cells were infected with or without T. gondii to isolate exosomes. The cellular growth patterns were identified by cell counting with trypan blue under confocal microscopy, and cell cycle changes were investigated by flow cytometry. L6 cells infected with T. gondii showed decreased proliferation compared to uninfected L6 cells and revealed a tendency to stay at S or G2/M cell phase. The treatment of exosomes isolated from T. gondii-infected cells showed attenuation of cell proliferation and slight enhancement of S phase in L6 cells. The cell cycle alteration was not as obvious as reduction of the cell proliferation by the exosome treatment. These changes were transient and disappeared at 48 hr after the exosome treatment. Microarray analysis and web-based tools indicated that various exosomal miRNAs were crucial for the regulation of target genes related to cell proliferation. Collectively, our study demonstrated that the exosomes originating from T. gondii could change the host cell proliferation and alter the host cell cycle.

• Journal of Environmental Health Sciences
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• v.46 no.4
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• pp.388-397
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• 2020

Objectives: The aim of this study was to assess the association between the use of heated tobacco products (HTP) and suicidal behaviors such as suicidal ideation, suicide planning, and suicide attempts among adolescents in South Korea. Methods: The study used a cross-sectional design. Data was from the 15th Korea Youth Risk Behavior Web-based Survey (KYRBS) performed in 2019 by the Ministry of Education, Ministry of Health and Welfare, and Korean Center for Disease Control and Prevention. Heated tobacco product use was used as a main independent variable and suicide-related behaviors such as suicidal ideation, planning, and attempts were applied as dependent variables. Out of 60,100 students, 57,303 responded. Results: HTP use significantly increased the odds of a suicide attempt and suicide planning among adolescents. After controlling for confounders, when comparing 'current HTP users' with 'never HTP users', the adjusted odds ratio (OR) was 1.78 (95% confidence interval (CI): 1.38-2.30) for suicide attempts among adolescents. After controlling the confounders, comparing 'current HTP users' with 'never HTP users', the adjusted OR was 1.36 (95% CI: 1.06-1.73) for suicide planning among adolescents. For sadness/despair among adolescents, when comparing 'current HTP users' with 'never HTP users', the adjusted OR was 1.29 (95% CI: 1.11-1.50). However, HTP use had no significant association with suicidal ideation among adolescents. Conclusions: Current HTP users were more likely to attempt to commit suicide, and more likely to plan to commit suicide than never HTP users among adolescents. These results may be useful in developing a scientific basis for designing suicide prevention programs targeting adolescents.

• Journal of the Korean Society for Library and Information Science
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• v.44 no.1
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• pp.53-74
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• 2010

This study investigated the self-archiving venues that university faculty members have used, the types of content that they have made publicly accessible on the web, and their rationales for such decisions. The present study was based on the analysis of 480 survey responses and 41 telephone interviews from professors at 17 Carnegie Doctorate-granting universities in the U.S. It was found that faculty members tended to self-archive referred articles on their personal websites or research group websites. This indicated that the faculties perceived peer-review process to be important in self-archiving practices as a quality-control mechanism. The rate of self-archiving in institutional repositories was low, although several interviewees envisioned the potential of the repositories regarding the ability to preserve various types of research works in digital form.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2003.05a
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• pp.648-652
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• 2003

In the GPRS(General Packet Radio Service) network, the transport layer between SGSN(Serving GPRS Support Node) and GGSN (Gateway GPRS Support Node) is based on IP-Over ATM Network. which means that the connectionless IP traffic is transmitted through connection oriented ATM transport layer. Efficient resource management is needed to perform connection and disconnection of the pertinent VC because of the connectionless IP traffic being passed through ATM transport layer In this paper, Internet Web service traffic model in the GPRS network is applied to the various VC holding Cost Pricing Model. each method is compared through analyzing each VC utilization and setup rate.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.38C no.4
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• pp.371-377
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• 2013

Fishing boats more than 5 tons is obliged to VHF DSC by Fishing Vessels Act and Vessel Safety Act. The owner of the fishing vessel is equipped to the automatic position reporting device in accordance with the Notice of the Minister of Land, Transport and Maritime Affairs to regulations, shall be ensure to navigations safety and in order to respond quickly in the event of maritime accidents on fishing vessels. East sea set up to start in 2012, which is now underway the annual install plain to the yellow sea and the south sea for VHF coast stations. It is web-based remote operation of DSC on the remote control and monitoring in Fishery Information Communication Station for the coastal VMS construction project. All fishing vessels is VHF DSC in conjunction with the GPS that location information transmitted to the coast station. automatically by the DSC call. This paper has been studied on the communications coverage set up and traffic operation for realization a roaming service by navigation route tracking and RSSI techniques in parallel algorithm refer to VHF DSC coast stations in east sea.

• Journal of the Korean Society for information Management
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• v.35 no.3
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• pp.165-187
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• 2018

Despite repeated efforts to develop a methodological foundation for assembling collaborative authority data in South Korea, issues such as the establishment of a standard authority model and standard authority construction as well as the reconfiguration of existing entities in authority building have prevented such research from generating a cooperative push for nation-wide authority data and progressing toward concrete implementation. The formulation of a collaborative and well-utilized collection of national authority data accordingly calls for 1) a practical approach to supporting both established authority data contributors and newly organized avenues of mutual participation in authority building, 2) committed involvement on the part of national institutions capable of providing the project with sustained assistance, and 3) a standard identification system which allows multiple organizations to merge their data. This study addresses the challenges of the current environment by taking stock of the key components necessary for the creation of collaborative authority data and using a Semantic Web-based interoperable VIVO ontology model to propose a viable national authority data framework.

• Asian Pacific Journal of Cancer Prevention
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• v.15 no.6
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• pp.2571-2576
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• 2014

Background: Published studies on the association between the exonuclease 1 (EXO1) Glu589Lys polymorphism and cancer susceptibility have yielded conflicting results. Thus, a meta-analysis of published studies was performed to assess the possible association. Materials and Methods: All eligible case-control studies published up to January 2013 on the association between the EXO1 Glu589Lys polymorphism and cancer susceptibility were identified by searching PubMed, Web of Science, Science Direct and hand search. Either fixed-effect or random-effect models were used to calculate pooled odds ratios (ORs) with 95% confidence intervals (CIs) using the Comprehensive Meta-Analysis software version 2.2. Results: A total of 4,391 cancer cases and 4,339 controls from 10 studies were included. Overall, no significant association between the EXO1 Glu589Lys polymorphism and cancer susceptibility was observed in either genetic model. However; in subgroup analyses by cancer type, a significant association between EXO1 Glu589Lys and lung cancer risk was found (Lys vs Glu: OR=1.23, 95%CI=1.07-1.41, $p_{heterogeneity}$=0.05). Further, subgroup analysis by ethnicity indicated that there was a statistically increased cancer risk in Asians (Lys vs Glu: OR=1.42, 95%CI=1.30-1.55, $p_{heterogeneity}$=0.07; Lys/Lys vs Glu/Glu: OR=1.93, 95%CI=1.20-3.12, $p_{heterogeneity}$=0.01; Lys/Lys+Glu/Lys vs Glu/Glu: OR=1.52, 95%CI=1.37-1.68, $p_{heterogeneity}$=0.42; Lys/Lys vs Glu/Lys+Glu/Glu: OR=1.68, 95%CI=1.07-2.65, $p_{heterogeneity}$=0.02). However, significant association was absent in Caucasians. Conclusions: This meta-analysis suggests, for the first time, that the EXO1 Glu589Lys polymorphism is not associated with overall cancer susceptibility, although marginal associations were found for lung cancer and Asian subgroups. Additional well-designed studies with larger sample size focusing on different ethnicities and cancer types are needed to confirm these findings.

• Journal of Korea Multimedia Society
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• v.12 no.10
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• pp.1499-1507
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• 2009

With the abundance of digital contents, the necessity of precise indexing technology is consistently required. To meet these requirements, the intelligent software entity needs to be the subject of information retrieval and the interoperability among intelligent entities including human must be supported. In this paper, we analyze the unifying framework for multi-modality indexing that Snoek and Worring proposed. Our work investigates the method of improving the authenticity of indexing information in contents-based automated indexing techniques. It supports the creation and control of abstracted high-level indexing information through ontological concepts of Semantic Web skills. Moreover, it attempts to present the fundamental model that allows interoperability between human and machine and between machine and machine. The memory-residence model of processing ontology is inappropriate in order to take-in an enormous amount of indexing information. The use of ontology repository and inference engine is required for consistent retrieval and reasoning of logically expressed knowledge. Our work presents an experiment for storing and retrieving the designed knowledge by using the Minerva ontology repository, which demonstrates satisfied techniques and efficient requirements. At last, the efficient indexing possibility with related research is also considered.

• The Journal of Korean Society for School & Community Health Education
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• v.14 no.2
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• pp.1-14
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• 2013

Objectives: The purpose of this study was to identify the relationship of internet use time and health risk behaviors among adolescents and provide data to set up a strategy for preventing internet addiction. Methods: The data of the 2011 Youth Health Risk Behavior web-based Survey Collected by Korean Center for Disease Control was analyzed using t-test, ANOVA, Chi-square test for this study. Results: There were significant differences between boys and girls in internet use time. Boy's internet use time was different according to city size(F=13.20, p<.001), grade(F=35.85, p<.001), school record(F=298.95, p<.001), economic state(F=326.75, p<.001), living with parents(t=11.60, p<.001), father's education level(F=147.92, p<.001), and mother's education level(F=110.93, p<.001). Girls' internet use time was also different according to school grade(t=-8.68, p<.001), grade(F=61.03, p<.001), school record(F=233.32, p<.001), economic state(F=185.78, p<.001), living with parents(t=10.81, p<.001), father's education level(F=86.54, p<.001), and mother's education level(F=92.64, p<.001). Regarding the health risk behaviors, present smoking, present alcohol drink, drug use skipping breakfast, eating fast food, drinking soda, sexual behavior, suicidal attempt, engagement time in physical education classes, severe exercise, and sleeping satisfaction made differences in the internet use time. Conclusions: The results suggest that health risk behaviors are influenced by internet use time of adolescents. Thus, these results may be contribute to development of programs to prevent internet addiction.

• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.3009-3014
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• 2015

The epidermal growth factor (EGF) may play a pathological role in hepatocellular carcinoma (HCC). However, the conclusions of published reports on the relationship between the EGF $61^*A/G$ polymorphism and HCC risk remain controversial. To derive a more precise estimation we performed a meta-analysis based on 14 studies that together included 2,506 cases and 4,386 controls. PubMed, EMBASE, Web of Knowledge and the Chinese National Knowledge Infrastructure (CNKI) databases were used to retrieve articles up to August 1, 2014. The crude odds ratios (ORs) with 95% confidence intervals (95%CIs) were calculated to evaluate the association. Meta-analysis results showed a significant association between the EGF $61^*A/G$ polymorphism and HCC risk in all four genetic models (allele model: OR=1.25, 95%CI=1.12-1.40; dominant model: OR=1.32, 95%CI=1.14-1.54; recessive model: OR=1.33, 95%CI=1.12-1.58; ho-mozygous model: OR=1.59, 95%CI=1.33-1.90). Moreover, significant associations were observed when stratified by ethnicity, source of controls, etiology and genotype methods. Thus, this meta-analysis suggests that the G-allele of the EGF $61^*A/G$ polymorphism is associated with an increased risk of HCC, especially in Asians and Caucasians, without influence from the source of controls or etiological diversity. Further studies with larger population sizes are needed to confirm these results.