• The Korean Journal of Physiology
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• v.25 no.2
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• pp.147-158
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• 1991

The effects of noradrenaline on the spontaneous contraction recorded from a strip of mucosa-free antral circular muscle were studied in the guinea-pig stomach, and the changes in slow waves and membrane resistance were analyzed in order to elucidate the mechanism for the excitatory response to noradrenaline. Electrical responses of circular muscle cells were recorded using glass microelectrodes filled with 3 M KCI. Electrotonic potentials were produced to estimate membrane resistance by the partition stimulating method. All experiments were performed in tris-buffered Tyrode solution which was aerated with 100% $O_2$ and kept at $35^{\circ}C$. The results obtained were as follows: 1) The spontaneous contractions were potentiated dose-dependently by the application of noradrenaline. 2) Through the experiments using adrenoceptor-blockers, the strong excitatory effect via $[\alpha}-adrenoceptors$ and the weak inhibitory efffect via ${\beta}-adrenoceptors$ were noted. 3) Noradrenaline produced hyperpolarization of membrane potential, and increases in the amplitude and the maximum rate of rise of slow waves. 4) In the presence of apamin, Ca-dependent K channel blocker, the characteristic hyperpolarization was not developed. However, the excitatory effect of noradrenaline on spontaneous contraction remained. 5) Membrane resistance was reduced during the hyperpolarized state by the application of noradrenaline, and the change of membrane resistance and the hyperpolarized state were completely abolished by apamin. From the above results, following conclusions could be made: Excitatory responses to noradrenaline result from the dominant ${\alpha}-excitatory$, and the weak ${\beta}-inhibitory$ action of noradrenaline. Hyperpolarization of membrane potential by noradrenaline is due to the activation of Ca-dependent K channel.

• The Korean Journal of Physiology and Pharmacology
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• v.15 no.6
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• pp.371-382
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• 2011

We performed experiments using Aplysia neurons to identify the mechanism underlying the changes in the firing patterns in response to temperature changes. When the temperature was gradually increased from $11^{\circ}C$ to $31^{\circ}C$ the firing patterns changed sequentially from the silent state to beating, doublets, beating-chaos, bursting-chaos, square-wave bursting, and bursting-oscillation patterns. When the temperature was decreased over the same temperature range, these sequential changes in the firing patterns reappeared in reverse order. To simulate this entire range of spiking patterns we modified nonlinear differential equations that Chay and Lee made using temperature-dependent scaling factors. To refine the equations, we also analyzed the spike pattern changes in the presence of potassium channel blockers. Based on the solutions of these equations and potassium channel blocker experiments, we found that, as temperature increases, the maximum value of the potassium channel relaxation time constant, ${\tau}_n(t)$ increases, but the maximum value of the probabilities of openings for activation of the potassium channels, n(t) decreases. Accordingly, the voltage-dependent potassium current is likely to play a leading role in the temperature-dependent changes in the firing patterns in Aplysia neurons.

• The Korean Journal of Physiology
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• v.6 no.2
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• pp.49-56
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• 1972

This experiment was designed to explore specific functional relationship between the vestibular canals and the extraocular oblique muscles by observing the isometric tension responeses of the muscles to the selected vestibular canal excitation. The vestibular excitation was simulated by either stimulation of the individual canal nerve or endolymphatic fluid displacement in each canal. Each canal nerve was subjected to square wave pulses with a monopolar wire electrode placed closely to the ampullary nerve endings for electrical stimulation, and a fine stainless cannula was introduced into the each canal toward the ampulla and a minute amount $(0.5{\sim}3.5\;microliter)$ of fluid was injected in or ejected out by means of a microsyringe connected to the cannula to produce ampullopetal or ampullofugal displacement of endolymphatic fluid. The superior oblique muscle was contracted by the excitation of homolateral canals and was relaxed by contralateral canals. On the contrary, the inferior oblique was contracted by the contralateral canals and was relaxed by the homolateral canals. Summation of excitatory and inhibitory canal effects from the bilateral vestibular system was demonstrable on the tension changes of the oblique muscles. Excitation of either dual or triple canals of the unilateral vestibular system also caused summation effect on the tension response of the oblique pair; thus multiple signals from the different ampullary receptors seems to be converged into the relevant ocular motor muclei. Since the superior and inferior obliques are known to receive their motor fibers from the contralateral trochlear nuclei and intermediate nuclei of the homolateral oculomotor complex respectively, the above experimental evidences indicate that the ocular motor nuclei for oblique muscles receive excitatory signals from the contralateral vestibular canals and inhibitory signals from the homolateral canals.

• Journal of Ocean Engineering and Technology
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• v.22 no.4
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• pp.65-71
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• 2008

In many cases, open-type plate breakwaters use plates with multiple holes; the holes serve as energy dissipaters and weight reducers. Because of the multi-holes configuration, stress concentration should be considered during the design process. Among several design loading conditions, the loads from a possible collision with a man-made vessel or other unexpected events many damage a multi-perforated steel plate. In that case, the structural behavior of a multi-perforated steel plate is quite significant, and is not well understood. This study presents a collision analysis for a multi-perforated steel plate. First, four different perforation topologies (three with circles and one with squares) were selected to investigate the effect of different hole shapes on the structural response. Second, the wave force at a specific site was calculated and loaded onto a steel plate as a static load. The static stresses were used for reference values. Third, two rigid body impacters (cubical & cylindrical) were applied to the steel plates to investigate the transient stress responses. In addition, two different impacting angles ($45^{\circ}\;&\;90^{\circ}$) were selected to investigate the angle effect. From the collision analysis, the significance of the transient stresses was emphasized.

• Journal of Ocean Engineering and Technology
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• v.32 no.1
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• pp.1-8
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• 2018

In order to analyze the response of the offshore structure numerically, the linear potential theory is generally applied for simplicity, and only the radiation damping is considered among various damping forces. Therefore, the results of a numerical simulation can be different from the motion of the structure in a real environment. To reduce the differences between the simulation results and experimental results, the viscous damping, which affects the motion of the structure, is also taken into account. The appropriate damping model is essential for the numerical simulation in order to obtain precise responses of the offshore structure. In this study, various damping models such as linear or quadratic damping and the nonlinear drag force from numerous slender bodies were used to simulate the free decay motion of the platform, and its characteristics were confirmed. The optimized damping model was found by comparing the simulation results to the experimental results. The hydrodynamic forces and wave exciting forces of the structure were obtained using WAMIT, and the free decay test was simulated using OrcaFlex. A free decay test of the scale model was performed by KRISO.

• Proceedings of the Korean Geotechical Society Conference
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• 2005.03a
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• pp.1118-1125
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• 2005

In this study, seismic safety of CFRD(Concrete-Face Rockfill Dam) type "D" dam in operation is evaluated from the results of 1-g shaking table test using similitude laws. Model dam is made by similitude law considering the grain size of prototype dam component. After the model dam is impounded to the normal water level(N.W.L), it is excited by artificial earthquake wave corresponding to standard design respond spectrum of the "D" dam site. Displacement response behavior of the dam is examined through the measurement of vertical and horizontal displacement of dam crest. Also, amplification characteristics of acceleration with dam height is examined through the measurement of acceleration with dam height. Finally, the purpose of this study is to evaluate seismic safety of "D" dam in operation. From the results of acceleration measurement, it was found that acceleration of dam crest was amplified about 1.52 times compared to the acceleration of dam bottom and amplification phenomenon is outstanding at three quarters of dam height from the bottom of dam. From the analysis of displacement behavior, it was estimated that vertical displacement of prototype dam is 6.8cm (0.1% of dam height) and horizontal displacement 12.3cm(0.2% of dam height). These percentages is much lower than 1% of dam height(general stability criteria). Therefore, it was concluded that seismic stability of "D" dam against an estimated earthquake is guaranteed.

• Journal of the Korean Society for Nondestructive Testing
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• v.29 no.1
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• pp.15-20
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• 2009

The results of crack evaluation by conventional UT(Ultrasonic Test)is highly depend on the inspector's experience or knowledge of ultrasound. Phased array UT system and its application methods for small crack length evaluation will be a good alternative method which overcome present UT weakness. This study was aimed at checking the accuracy of crack length evaluation method by electronic scanning and discuss about characteristics of electronic scanning for crack length evaluation. Especially ultrasonic phased array with electronic scan technique was used in carrying out both sizing and detect ability of crack as its length changes. The response of ultrasonic phased array was analyzed to obtain the special method of determining crack length without moving the transducer and detect-ability of crack minimal length and depth from the material. A method of crack length determining by electronic scanning for the small crack is very real method which has it's accuracy and verify the effectiveness of method compared to a conventional crack length determination.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2001.05a
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• pp.478-483
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• 2001

We experimentally attempted to understand the vibration characteristics of a flexible pipe excited by vortex shedding. This has been extensively studied in the past decades (For example, see ［2-9］). However, there are still areas that need more study. One of them is to study the relation between spatial characteristics of a flow induced vibrating pipe, such as its length, the distribution of wave number, and frequency responses. A non-linear mechanism between the responses of in-line and cross-flow directions is also an area of interests, if the pipe is relatively long so that structural modal density is reasonably high. In order to investigate such areas, two kinds of instrumented pipe were designed. The instrumented pipes, of which the lengths are equally 6m, are wound with rubber and silicon tape in different ways, having different vortex shedding conditions. One has uniform cross-section of diameter of 26. 7mm, and the other has equally spaced by 4 sub-sections, which are composed of different diameters of 75.9, 61.1, 45.6 and 26.7mm. Both pipes are towed in a water tank (200m ${\times}$ 16m ${\times}$ 7m) so that they experienced different vortex shedding excitations. The towing pipe experiments exhibit several valuable features. One of them is that the natural frequencies and their corresponding strain mode shapes dominate the strain response of the uniform pipe. However, for those of non-uniform pipe, the responses are more likely local and many modes participate in it.

• Coupled systems mechanics
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• v.6 no.3
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• pp.229-249
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• 2017

A new technique to mitigate irregular buildings with soil structure interaction (SSI) effect subjected to critical seismic waves is presented. The L-shape in plan irregular building for various reasons was selected, subjected to seismic a load which is a big problem for structural design especially without separation gap. The L-shape in plan building with different dimensions was chosen to study, with different rectangularity ratios and various soil kinds, to show the effect of the irregular building on the seismic response. A 3D building subjected to critical earthquake was analyzed by structural analysis program (SAP2000) fixed and with SSI (three types of soils were analyzed, soft, medium and hard soils) to find their effect on top displacement, base shear, and base torsion. The straining actions were appointed and the treatment of the effect of irregular shape under critical earthquake was made by using tuned mass damper (TMD) with different configurations with SSI and without. The study improve the success of using TMDs to mitigate the effect of critical earthquake on irregular building for both cases of study as fixed base and raft foundation (SSI) with different TMDs parameters and configurations. Torsion occurs when the L-shape in plan building subjected to earthquake which may be caused harmful damage. TMDs parameters which give the most effective efficiency in the earthquake duration must be defined, that will mitigate these effects. The parameters of TMDs were studied with structure for different rectangularity ratios and soil types, with different TMD configurations. Nonlinear time history analysis is carried out by SAP2000 with El Centro earthquake wave. The numerical results of the parametric study help in understanding the seismic behavior of L-shape in plan building with TMDs mitigation system.

• Journal of the Society of Naval Architects of Korea
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• v.32 no.3
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• pp.37-43
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• 1995

The procedure and the results of the full scale strain measurement of the long-range high-speed foil catamaran are described. The wave induced stresses at the center struts of the foils were measured during the sea trials in order to evaluate the hydrodynamic force acting on the foils and to verify the structural safety of the foil structures. From the statistical properties of the measured response of the stress, the most probable maximum values of the lift force and the stresses at the foils in service life of the ship are predicted and compared with the design parameters of the foils which were applied in the design of the subject ship. The available prediction processes of the measured stress are studied and the results of the applied processes are compared with each other.