• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.40 no.1
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• pp.3-10
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• 2014

Objectives: Although nerve growth factor (NGF) could promote the functional regeneration of an injured peripheral nerve, it is very difficult for NGF to sustain the therapeutic dose in the defect due to its short half-life. In this study, we loaded the NGF-bound heparin-conjugated fibrin (HCF) gel in the NGF-delivering implants and analyzed the time-dependent release of NGF and its bioactivity to evaluate the clinical effectiveness. Materials and Methods: NGF solution was made of 1.0 mg of NGF and 1.0 mL of phosphate buffered saline (PBS). Experimental group A consisted of three implants, in which $0.25{\mu}L$ of NGF solution, $0.75{\mu}L$ of HCF, $1.0{\mu}L$ of fibrinogen and $2.0{\mu}L$ of thrombin was injected via apex hole with micropipette and gelated, were put into the centrifuge tube. Three implants of experimental group B were prepared with the mixture of $0.5{\mu}L$ of NGF solution, $0.5{\mu}L$ HCF, $1.0{\mu}L$ of fibrinogen and $2.0{\mu}L$ of thrombin. These six centrifuge tubes were filled with 1.0 mL of PBS and stirred in the water-filled beaker at 50 rpm. At 1, 3, 5, 7, 10, and 14 days, 1.0 mL of solution in each tubes was collected and preserved at $-20^{\circ}C$ with adding same amount of fresh PBS. Enzyme-linked immunosorbent assay (ELISA) was done to determine in vitro release profile of NGF and its bioactivity was evaluated with neural differentiation of pheochromocytoma (PC12) cells. Results: The average concentration of released NGF in the group A and B increased for the first 5 days and then gradually decreased. Almost all of NGF was released during 10 days. Released NGF from two groups could promote neural differentiation and neurite outgrowth of PC12 cells and these bioactivity was maintained over 14 days. Conclusion: Controlled release system using NGF-HCF gel via NGF-delivering implant could be an another vehicle of delivering NGF to promote the nerve regeneration of dental implant related nerve damage.

• Journal of Korean Society for Atmospheric Environment
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• v.21 no.4
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• pp.439-458
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• 2005

An automated analysis system for water soluble constituents in $PM_{2.5}$ has been developed. The system consists of a high capacity multi tube diffusion scrubber (MTDS), a low temperature particle impactor (LTPI), and two ion (anion and cation) chromatography (IC) systems. Atmospheric particles have been collected by passing sample air through a thermostated MTDS followed by a LTPI. This system allows simultaneous measurements of soluble ions in $PM_{2.5}$ at 30 minutes interval. At the air sampling flow rate of 1.0L/min, the detection limits of the overall system are in the order of tens of $ng/m^3$. This system has been successfully used for the measurement of particulate components of Seoul air from April 2003 to January 2004. $SO_4^{2-},\;NO_3^-,\;NH_4^+,\;NO_2^-,\;Cl^-,\;Na^+,\;K^+,\;Ca^{2+},\;and\;Mg^{2+}$ are the major ionic species for $PM_{2.5}$ at Seoul. Among them, $SO_4^{2-},\;NO_3^-\;and\;NH_4^+$ are the most abundant ions, contributed up to $86\%$ of the total and the concentrations were higher than those in any other urban sites in the world except for Chinese cities. There are high pollutant episodes which contribute about $15\~20\%$ of annual average values of the major ions. During the episode, the all parcels were transported from the asian continent and $PM_{2.5}$ were significantly neutralized. This suggests that aged and long range transported pollutants caused the high pollutant episodes. They showed a distinct daily and seasonal variations:they showed a peak in the early morning caused by the night-time accumulation of particulate matters. Atmospheric reactions including gas-to-particle reactions and inter-particle reactions and meteorological parameters including relative humidity and ambient temperature were described with related to the $PM_{2.5}$ 5 concentrations. All of the ionic species showed higher concentrations during the spring than those for summer and winter.

• Journal of the Korean Applied Science and Technology
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• v.37 no.3
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• pp.516-525
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• 2020

The densities of aqueous solutions of the amphiphile 2-(2-hexyloxyethoxy)ethanol (C₆E₂) were measured at 279.15 K and 282.15 K by vibrating-tube densitometry. Then using the density data of the binary C₆E₂ (1)/water(2) system, the excess volumes and partial molar volumes were determined at various compositions. Excess volume V^E exhibits negative deviation for the whole region of composition, which implies relatively stronger attraction between molecules. At the C₆E₂ mole fraction of around 0.45, V^E was at its minimum. Partial molar volume ${\bar{V}}_1$ increases monotonously with the mole fraction x₁(=x) and ${\bar{V}}_2$ decreases with x. Any particular point in ${\bar{V}}_1$ and ${\bar{V}}_2$, which may point to molecular association, was unobserved.

• The Journal of Engineering Geology
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• v.25 no.4
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• pp.473-484
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• 2015

Geophysical exploration using electric resistivity, ground penetrating radar (GPR), and impedance high-frequency (ZHF) surveys was conducted in Gujwa-eup, Jeju City, Jeju Island, an island in the Korea Strait, to confirm the existence of new caves near known caves. The exploration revealed a number of anomaly zones, presumed to be caves; 27 sites at suitable locations and depth ranges were selected for drilling and further surveys. However, contrary to predictions, most of the anomaly zones were clinker layers or paleosols intercalated with lavas. Only five boreholes intersected caves. The clinker layers and paleosols were possibly detected as anomalies owing to their different physical properties from the other rocks. Two of the five cave-finding boreholes penetrated Yongcheon Cave; a new cave was found at the other. The two boreholes that penetrated Yongcheon Cave were drilled in areas where the cave has not been previously reported, and thus helped correct an error in the cave distribution map. The cave newly discovered in this boring exploration is 180 m long, and it is connected to the upstream part of Dangcheomul Cave (110 m). The cave contains well-developed lava helictites, lava levees, and ropy structures; carbonate speleothems such as soda straws, stalagmites, columns, and curtain shawls are also well preserved. Notably, the unique shape of the carbonate speleothems is attributed to their growth in relation to the cavern water that flowed into the cave along plant roots.

• Analytical Science and Technology
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• v.15 no.6
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• pp.502-508
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• 2002

See-through hollow cathode glow discharge cell has been developed for the trace analysis of metal ions. The systems consists of new glow discharge cell improved the cooling system. In the case of previous type of hollow cathode glow discharge cell, it had been utilized for the trace analysis of metal ions but it had a problem that the plasma becomes unstable by air-cooled device. In this study, the modified hollow cathode glow discharge cell has been developed in order to minimize the problem associated with the air-cooled device. thus the stability of the plasma with water-cooling device has been improved and also the higher plasma temperature has been measured. The fundamental characteristics of modified systems have been investigated. And the discharge parameters, such as discharge pressure, material, and diameter of cathode, have been studied to find optimum discharge conditions.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.7 no.2
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• pp.113-119
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• 2006

Brazing is an important manufacturing process in the fabrication of Heavy Water Reactor fuel rods, in which bearing and spacer pads are joined to Zircaloy-4 cladding tubes. The physical vapor deposition(PVD) technique is currently used to deposit metallic Be on the surfaces of pads as a filler metal. Amorphous Zr-Be binary alloys which are manufactured by rapid solidification process are under developing to substitute the conventional PVD-Be coating. In the present study, brazed joint with PVD and amorphous alloys of $Zr_{1-x}Be_{x}(0.3{\le}x{\le}0.5)$ as filler metals are compared by mechanism, microstructure and hardness. The thickness of brazed joint with amorphous alloys became much smaller than that of PVD-Be. The erosion of base metal did not occur in the brazed joint with amorphous alloys. The brazing mechanism for PVD-Be seems to be Be diffusion into Zr-4 with capillary action resulting from eutectic reaction while that for amorphous alloys are associated with the liquid phase formation in the brazed joint. The brazed joint microstructure with PVD-Be consists of dendrite while that with amorphous alloys is globular. The $Zr_{0.7}Be_{0.3}$ alloy shows the smooth interface with little erosion in the base metal and is recommended a most suitable brazing filler metal for Zircaloy-4.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.718-723
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• 2016

The use of the scroll compressor in the air conditioning of medium-sized vehicles has increased because of its low torque fluctuation, high energy efficiency and low noise. In addition, the main components of the compressor have been changed from steel to aluminum to reduce its weight, following studies on the constituent materials. The processing precision of the fixed scroll and orbiting involute scroll wrap of the scroll compressor must be below $10{\mu}m$. To ensure this, the surface roughness and contour tolerance are measured. To improve the hardness of the orbiting scrolls using aluminum subjected to anodizing treatment and as the base material, we used a sealing treatment and measured the resulting characteristics. The aluminum materials were made of an Al-Mg-Cu based alloy including small amounts of Ni, Fe, and Zn. The surface roughness was less than $3{\mu}m$ and the processing accuracy was within $10{\mu}m$. Also, the hardness of the nanodiamonds with CNTs used in the sealing treatment was more than 450. This was found to improve the hardness of the material by 50% or more compared to the water sealing treatment and there was little difference between the use of carbon nanotubes and nanodiamonds as sealing materials.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.1-11
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• 2016

The effect of the migration of nanoparticles near the wall of a channel on the convective heat transfer in a laminar flow of $SiO_2$ nanoparticle suspensions (nanofluids) under constant wall heat flux boundary conditions was numerically and experimentally investigated in this study. The dynamic thermal conductivity of the aqueous $SiO_2$ nanofluids was measured using T-type thermocouples attached to the outer surface of a stainless steel circular tube (with a length of 1 m and diameter of 1.75 mm). The nanofluids used in this study were synthesized by dispersing $SiO_2$ spherical nanoparticles with a diameter of 24 nm in de-ionized water (DIW). The enhancement of the thermal conductivity of the nanofluids (e.g., an increase of up to 7.9 %) was demonstrated by comparing the temperature profiles in the flow of the nanofluids with that in the flow of the basefluids (i.e., DIW). However, this trend was not demonstrated in the computational analysis, because the numerical models were based on continuum assumptions and flow features involving nanoparticles in a stable colloidal solution. Thus, to explore the non-continuum effects, such as the modification of the morphology caused by nanoparticle-wall interactions on the heat exchanging surfaces (e.g., the isolated and dispersed precipitation of the nanoparticles), additional experiments were performed using DIW right after the measurements using the nanofluids.

• Journal of The Geomorphological Association of Korea
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• v.21 no.4
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• pp.149-164
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• 2014

The representative landscapes in Jeju Island called as Ten sceneries of Yeongju originates with Ten sceneries of Tamra which were organized in the late seventeenth century by Jeju governor Lee Iktae. In order to compose ten representative sceneries in Jeju Island, he selected four strongholds such as Jocheon, Byeolbang, Seogwi and Myeongwol and six places of scenic beauty such as Seongsan, Baekrokdam, Yeonggok, Cheonjiyeon, Sanbang and Chwibyeongdam, and made a painting named as Ten sceneries of Tamra. Since the scenes of strongholds also exhibit a lot of geomorphic landscapes, the painting could be considered a collection of representative landforms in Jeju Island. The painting depicts several types of landform such as volcano, crater, river, waterfall, pool, wetland, cavern, tor and rocky coast. The volcanic edifice appears most frequently in the painting, reflecting the particular emotion of Jeju people on Mt. Halla and oreums. However, another volcanic landform, a lava tube, was not highly evaluated due to its negative images. Three famous waterfalls in Jeju Island were included in Ten sceneries of Tamra, and it suggests that they are essentially outstanding landforms, and besides, there are few sites related with fresh water in Jeju Island. The ten sceneries were entirely organized in spite of the limitation of selecting places at that time. The landscape images of Jeju Island, which had been shared as collective representation by Jeju people, were firstly externalized through Lee Iktae's painting, and have long been passed down and established a kind of scenic stereotype.

• Journal of the Korean Society of Hazard Mitigation
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• v.11 no.3
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• pp.117-125
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• 2011

River bed variation drops storage capacity of dams and reservoirs, and furthermore deteriorates safety of banks and peers. Therefore, understanding of bed variation is important to use and manage river water. Study section is downstream part of Ji- Cheon nearby Ji-Cheon Bridge which is located in Gum river basin. The river surveying at fourteen places with the length of 1,320m were undertaken on November 7, 2003 and September 24, 2004, and the results of river surveying were analyzed for the study. Real bed variation was compared with the simulation results of HEC-6 and GSTARS 3.0. Cross section data for the simulation of HEC-6 and GSTARS3.0 were composed of the basis of river surveying data on November 7, 2003. Hydrological data were acquired from Gu-Ryong watermark located at Ji-Chun Bridge. The research results revealed that when using Toffaleti equation, simulation results of two models were similar to the real bed variation. The bed variation simulated by using GSRARS 3.0 with only one stream tube was similar to the real bed variation. The bed variation simulated by using two models(HEC-6 and GSTRARS 3.0) with Toffaleti equation was also similar to the real bed variation. Therefore, it is expected that HEC-6 and GSTARS 3.0 models have applicability to predict the bed variation at the downstream of Ji-Cheon.