• Korean Circulation Journal
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• v.52 no.3
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• pp.205-217
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• 2022

Background and Objectives: The prognostic value of left atrial (LA) function in terms of long-term clinical outcomes after mitral regurgitation (MR) surgery remains unclear. Therefore, we investigated the impact of preoperative LA global longitudinal strain (LAGLS) on the long-term postoperative clinical outcomes in chronic severe MR patients who underwent mitral valve (MV) repair surgery. Methods: From January 2012 to December 2017, we analyzed 338 patients (mean age, 51.9±12.5 years; 218 males [64.5%]) treated with MV repair surgery for severe MR. The primary outcome was cardiovascular events, defined as the composite of all-cause death, newly developed atrial fibrillation (AF), and re-hospitalization for cardiovascular causes. Results: During a median follow-up of 45 months (interquartile range, 26-65), 30 (8.9%) cardiovascular events, 5 (1.5%) all-cause death, 8 (2.4%) newly developed AF, and 26 (7.7%) re-hospitalizations occurred. On multivariable analysis, baseline LAGLS was an independent predictor of cardiovascular events (adjusted hazard ratio [HR], 0.91; 95% confidential interval [CI], 0.85-0.97; p=0.004) and re-hospitalization (adjusted HR, 0.93; 95% CI, 0.86-1.00; p=0.037). According to the optimal cutoff value of LAGLS, patients with low LAGLS (<23.6%) had a significantly higher risk of cardiovascular events (adjusted HR, 2.70; 95% CI, 1.04-7.00; p=0.041) than those with high LAGLS (≥23.6%). In a subgroup analysis, patients with high LAGLS had better clinical outcomes regardless of whether the patient had a LA volume index <60 mL/m². Conclusions: In patients with chronic severe MR who received successful MV repair surgery, preoperative LAGLS is an independent predictor of long-term postoperative outcomes.

• Journal of Korea Foundry Society
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• v.11 no.4
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• pp.331-337
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• 1991

Various test specimens were prepared by austempering low alloyed Mo-Ni-Cu ductile iron blocks of high graphite nodule count at 270, 320 or $370^{\circ}C$ for 0.5, 1, 3 or 9hrs. Tensile test, CVN impact test and plane-strain fracture toughness test(compact tension specimen of 50mm W) were done for each heat treatment condition at room temperature. X-ray diffractometer and optical microscope were used to investigate the change of microstructure and relationships between microstructure and test results. The highest retained austenite volume percent at each austempering temperature was corresponded to the highest mechanical property. The highest elongation value of 17%, U.T.S. value of 1,600 MPa or $K_{IC}$ value of 90MPa${\surd}$m were reached at each optimum condition. The best heat treatment condition for fracture toughness were 3hrs' holding time combined with the austempering temperature of 270 and $320^{\circ}C$, and 1hr's of $370^{\circ}C$.

• Geotechnical Engineering
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• v.11 no.3
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• pp.43-54
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• 1995

The aim of the work described in this paper is to develope a constitutive model for the prediction of an unsaturated soil and to confirm the application'of the model, which is composed of the elastic and plastic part in consideration of the matric suction and the net mean stress. From test results, volume changes and deviator stresses are analyzed at each state and their relationships are formulated. The application of the model to silty sands is confirmed by the comparison between test and predicted results. During drying -wetting and loading -unloading processes for isotropic states, the agreement between predicted and test results are satisfactory. Predicted deviator stresses are well agreed with test results in shearing process. Overall acceptable predictions are reproduced in high confining pressure. Usefulness of the model is confirmed for the unsaturated soil except volumetric strain, which is not well agreed with the test results due to deficiency of dilatancy of the model in low confining pressure. It is, therefore. recommended to study the behavior of dilatancy for an unsaturated soil.

• Korean Journal of Materials Research
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• v.14 no.3
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• pp.168-174
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• 2004

The aim of this study is to investigate the effect of process conditions on the microstructual changes and mechanical properties of large 7175 aluminum die forgings. The cast billets of 370 and 720 mm in diameter were homogenized and die forged after direct chill casting. The size and volume fraction of second phase particles in 720 mm billet were larger than those of 370 mm billet. The interdendritic sites containing the second phase particles was considered to be a crack initiation region in the process of cold upsetting. The tensile and yield strength of die forged specimens of 720 mm billet in the direction of Land L T were higher than those of 370 mm billet. However, the tensile strength of these specimens were 5 to 10% lower than that of American military specification. The plane strain fracture toughness of die forged specimens of 370 mm cast billet showed almost the same level of 720 mm billet, which was die forged after free forging.

• Biomedical Science Letters
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• v.18 no.3
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• pp.268-275
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• 2012

Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 4-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 16 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 3 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gammaglutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.

• Computers and Concrete
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• v.2 no.3
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• pp.189-202
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• 2005

This paper presents an analysis of some experimental results concerning micro-structural tests, permeability measurements and strain-stress tests of four types of High-Performance Concrete, exposed to elevated temperatures (up to $700^{\circ}C$). These experimental results, obtained within the "HITECO" research programme are discussed and interpreted in the context of a recently developed mathematical model of hygro-thermal behaviour and degradation of concrete at high temperature, which is briefly presented in the Part 2 paper (Gawin, et al. 2005). Correlations between concrete permeability and porosity micro-structure, as well as between damage and cracks' volume, are found. An approximate decomposition of the thermally induced material damage into two parts, a chemical one related to cement dehydration process, and a thermal one due to micro-cracks' development caused by thermal strains at micro- and meso-scale, is performed. Constitutive relationships describing influence of temperature and material damage upon its intrinsic permeability at high temperature for 4 types of HPC are deduced. In the Part II of this paper (Gawin, et al. 2005) effect of two different damage-permeability coupling formulations on the results of computer simulations concerning hygro-thermo-mechanical performance of concrete wall during standard fire, is numerically analysed.

• Steel and Composite Structures
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• v.20 no.4
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• pp.889-911
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• 2016

Using the hyperbolic shear deformation plate model and including plate-foundation interaction (Winkler and Pasternak model), an analytical method in order to determine the deflection and stress distributions in simply supported rectangular functionally graded plates (FGP) subjected to a sinusoidal load, a temperature and moisture fields. The present theory exactly satisfies stress boundary conditions on the top and the bottom of the plate. No transversal shear correction factors are needed because a correct representation of the transversal shearing strain is given. Materials properties of the plate (elastic, thermal and moisture expansion coefficients) are assumed to be graded in the thickness direction according to a simple power-law distribution in terms of the volume fractions of the constituents. Numerical examples are presented and discussed for verifying the accuracy of the present theory in predicting the bending response of FGM plates under sinusoidal load and a temperature field as well as moisture concentration. The effects of material properties, temperature, moisture, plate aspect ratio, side-to-thickness ratio, ratio of elastic coefficients (ceramic-metal) and three distributions for both temperature and moisture on deflections and stresses are investigated.

• Steel and Composite Structures
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• v.29 no.3
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• pp.363-377
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• 2018

An efficient and free of shear locking finite element model is developed and employed to study free vibration of tapered bidirectional functionally graded material (BFGM) beams. The beam material is assumed to be formed from four distinct constituent materials whose volume fraction continuously varies along the longitudinal and thickness directions by power-law functions. The finite element formulation based on the first-order shear deformation theory is derived by using hierarchical functions to interpolate the displacement field. In order to improve efficiency and accuracy of the formulation, the shear strain is constrained to constant and the exact variation of the cross-sectional profile is employed to compute the element stiffness and mass matrices. A comprehensive parametric study is carried out to highlight the influence of the material distribution, the taper and aspect ratios as well as the boundary conditions on the vibration characteristics. Numerical investigation reveals that the proposed model is efficient, and it is capable to evaluate the natural frequencies of BFGM beams by using a small number of the elements. It is also shown that the effect of the taper ratio on the fundamental frequency of the BFGM beams is significantly influenced by the boundary conditions. The present results are of benefit to optimum design of tapered FGM beam structures.

• Computers and Concrete
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• v.16 no.6
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• pp.825-846
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• 2015

In this study, shear tests on steel fiber reinforced-prestressed concrete (SFR-PSC) members were conducted with test parameters of the concrete compressive strength, the volume fraction of steel fibers, and the level of effective prestress. The SFR-PSC members showed higher shear strengths and stiffness after diagonal cracking compared to the conventional prestressed concrete (PSC) members without steel fibers. In addition, their shear deformational behavior was measured using the image-based non-contact displacement measurement system, which was then compared to the results of nonlinear finite element analyses (NLFEA). In the NLFEA proposed in this study, a bi-axial tensile behavior model, which can reflect the tensile behavior of the steel fiber-reinforced concrete (SFRC) in a simple manner, was introduced into the smeared crack truss model. The NLFEA model proposed in this study provided a good estimation of shear behavior of the SFRPSC members, such as the stiffness, strengths, and failure modes, reflecting the effect of the key influential factors.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2003.10a
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• pp.269-273
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• 2003

There is a growing interest to replace the commercial steels with non-heat treated steels, which does not involve the spheroidization and quenching-tempering treatment. However, Non-heat treated steels should satisfy high strength and good formability without performing heat treatment. Therefore, it is important to investigate optimum materials showing a good combination of strength and formability after the drawing process. In this study, Dual-Phase Steels were studied as candidate materials for non-heat treated steels, which have different martensite morphologies and volume fractions obtained through heat-treatment of intercritical quenching (IcQ), intermediate quenching (ImQ) and step quenching (SQ). The mechanical properties of DP steels were measured by tension and compression tests. Also, the cold formability of three DP steels which have similar tensile strength value was investigated by estimating the deformation resistance and the forming limit. The deformation resistance which is important factor in determining die life was estimated by calculating the deformation energy. And the forming limit was estimated by measuring the critical strain revealing crack initiation at the notch tip of the specimens.