Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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Historical Control Data from 4-week Repeated Toxicity Studies in Crj:CD (SD) Rats

  • Lee, Jung-Min (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Lee, Min-Ah (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Do, Hyeon-Nam (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Bae, Re-Ji-Na (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Lee, Mi-Ju (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Kim, Myoung-Jun (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Jang, Ho-Song (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Park, Sun-Hee (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Lee, Hye-Yeong (Pathology Department, Biotoxtech Co., Ltd.) ;
  • Kang, Jin-Seok (Department of Biomedical Laboratory Science, Namseoul University) ;
  • Kang, Jong-Koo (Laboratory Animal Medicine, College of Veterinary Medicine, Chungbuk National University)
  • Received : 2012.02.27
  • Accepted : 2012.07.04
  • Published : 2012.09.30
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Abstract

Reference ranges of standard experimental parameters are useful for comparisons in toxicology. The aim of this study was to collect data from 4-week repeated toxicity studies in Crl:CD (SD) rats, a strain widely used for toxicity and efficacy research, for establishing domestic reference values. Data on body weight, food consumption; urinalysis, hematological, and blood biochemical parameters; and organ weights were collected from 16 toxicity studies in 220 Crl:CD (SD) rats (110 males and 110 females). The studies had been performed at a single testing facility over the last 3 years and involved animals sourced from a single breeder. The findings were collated as means, standard deviations, percentages, and ranges. Urine volume, uterus weight, eosinophil, and basophil counts, and triglyceride, total bilirubin, and gammaglutamyl transpeptidase levels showed standard deviations of 30% or more. These historical control data would help to interpret the effects of test substances in routine toxicity and efficacy studies.

Keywords

References

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