• 한국식품조리과학회지
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• 제13권4호
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• pp.500-506
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• 1997

본 연구에서는 methanol로 온시여과 후 계통분획하여 감압농축하여 얻은 참마의 $H_2O$ 분획물을 vitamin E와 함께 STZ으로 당뇨를 유발시킨 흰쥐에게 14일간 경구투여한 후 혈당과 지질대사에 미치는 영향을 실험하여 다음과 같은 결과를 얻었다. 당뇨대조군은 당뇨로 인한 대사상의 변화로 정상군과는 다른 대사적인 차이를 나타내었다. 당뇨대조군과 참마와 vit. E 투여에 따른 당뇨실험군에서는 식이의 섭취와 식이효율에는 유의적인 차이가 없었다. 체중의 변화는 14일 후 참마와 vit. E 병용투여군에서 정상군과 유사한 수준이었고 전 실험기간동안의 체중의 변화는 실험군간에 점차 낮아지는 경향을 보였으나 유의적인 차이를 보이지 않았다. 장기의 무게를 체중 100 g 당으로 환산하였을 때 심장의 무게는 당뇨실험 군 중 vit. E 투여군에서 낮게 나타났으며 췌장의 무게는 당뇨대조군에 비해 모든 실험군에 낮게 나타났으나 유의적인 차이는 보이지 않았다. 혈장 단백질 수준은 당뇨대조군에 비해 당뇨실험군 모두에서 높게 나타났다. 혈장 인슬린의 함량은 모든 실험군에서 유의적인 차이를 보이지 않았으나 참마투여군에서 약간 높은 수준이었다. 혈장 포도당 수준도 당뇨대조군에 비해 당뇨실험군에서 낮아지는 경향을 보였다. 혈장지질 수준에 미치는 영향을 보면 중성지방과 유리지방산 함량은 당뇨대조군에 비해 vit. E군에서 낮은 수준을 보였으며 HDL-cholesterol 수준은 모든 당뇨실험군에서 높게 나타났다. 혈장 cholesterol 수준의 경우도 당뇨대조군과 실험군에서 큰 차이는 없었으나 vit. E군에서 낮은 수준을 보였다. AST및 ALT활성도는 실험군 간에 큰 차이를 보이지 않았다. 본 연구 결과 참마의 $H_2O$ 분획물은 vitamin E 병용 투여시 지방대사와 인슬린활성에 작용하여 혈당강하에 영향을 주는 생리활성성분을 함유하는 식품으로 당뇨식이처방에 유용하리라 생각되며 vitamin E 보충에 의한 대사적인 변화에 대하여 더 구체적인 생화학적인 연구가 이루어져야 될 것으로 여겨진다.

• Journal of Nutrition and Health
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• 제32권3호
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• pp.239-247
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• 1999

With the increasing elderly population in Korea, dementia has become a mojor health problem in Korea. Several studies have been conducted on the association between dementia and dietary intake, especially vitamin E and vitamin C. The purpose of this study was to investigate the effect of vitamin E and vitamin C supplementation on the decrease in cognitive function induced by scopolamine(300mg/kg) in rats. Rats were divided into three groups : control, vitamin C, and vitamin E supplementation(2.4g Vit C or Vit E /100g diet) and fed the diets for 6 weeks. There were significant decreases in active avoidance response and brain acetylcholinesterase activity in the control group, but no significant differences were observed in the vitamin E and C groups after scopolamine treatment. Brain dopamine concentration of vitamin E and C groups was significantly higher than those of control group after scopolamine injection. The concentrations of brain norepinephrine also showed similar tendence, even though it was not statistically significant. These results indicate that vitamin E and vitamin C may protect against the cognitive function decrease induced by scopolamine. However, it is still unclear how vitamin E and C influence brain neurotransmitters and improve cognitive function. Further study is need to elucidate the role of vitamin E and C supplementation in the prevention of dementia.

• 한국가금학회:학술대회논문집
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• 한국가금학회 2002년도 가을 학술발표논문집
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• pp.128-129
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• 2002

본 연구결과로 $\omega$-3 지방산을 포함한 지방산의 계란내 이행정도는 flaxseed의 첨가와 지방산대사에 영향을 미치는 미량 사료 첨가물질의 병용첨가로 변화되는 것으로 나타났으며, 특히 생균물질과 lecithin의 생리적 기능에 의한 계란내 $\omega$-3 지방산의 급증이 특이적인 것으로 나타났다. 그러나 미량 사료 첨가물질의 지방대사 조절기전에 관해서는 추가연구가 필요한 것으로 판단된다.

• 한국의류학회지
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• 제23권7호
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• pp.980-986
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• 1999

This study was done to ivestigate the fabrics thatminimized harmfulness of UVB(ultraviolet B) and that might product Vit. {{{{ {D }`_{3 } ^{ } }} by UVB. Twelve female subjects wearing in three different types i.e fabric A(UVB 100% protection) fabric B(UVB 50% protection) and bikinii were exposed to outdoor environment (Air Temp : 25℃, 42% R,H Air velocity : 0.13m/s UV does :6KJ/m2) Blood samples were taken 24 hours before the after the experiment in order to examine concentration of vit.{{{{ {D }`_{3 } ^{ } }} in the blood. During the experiment axillary temperature skin temperature of 7 areas(forehead Chest Upper arm, Hand Thigh Lower leg, Foot) were measured. The more irradiated areas by UVB were the more the concentration of serum 25(OH){{{{ {D }`_{3 } ^{ } }} were significantly. Mean skin temperature was significantly low levekl in wearing the fabric of UVB 50% protection (p<0.001) Axillary temperature was significantly high level in wearing the fabric of UVB 50% protection (p<0.001). Therefore the fabric of UVB 50% protection intercepts the radiation and has advantage to give off body heat over other fabrics

• Journal of Nutrition and Health
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• 제54권1호
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• pp.1-9
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• 2021

This review describes the risk factors of the nutrition crisis in coronavirus disease 2019 (COVID-19) infections and suggests precision nutrition against long-term psychological and physiological stress. The mandatory quarantine and the social distancing are associated with an interruption of the lifestyle routine, resulting in psychological (i.e., boredom) and physiological stress. The stress with multiple causes and forms induces over-compensation of energy-dense food, such as sugary comfort food, and is defined as "food craving" because carbohydrates positively affect the psychological stability with serotonin secretion. The consumption of foods that promote an immune response against viral infections (vitamins & minerals; Cu, folate, Fe, Se, Zn, and Vit A, B6, B12, C, and D), reduce inflammatory cytokines (w-3 fatty acids, Vit D, fibers, and Mg), contain antioxidants (beta-carotene, Vit E, C, Se, and phenolics), and sleep-inducing proteins (serotonin, melatonin, and milk products) is essential. In addition, a reduced Vit D deficiency in winter due to less time spent outdoors under quarantine has been reported to be associated with viral infections. The case fatality rate of COVID-19 was significantly dependent on age, sex, race, and underlying health condition. To prevent malnutrition and cachexia in elderly people, weight loss and muscle wasting should be monitored and controlled. Inadequate protein intake, sedentary lifestyle, and inflammation are significant risk factors for sarcopenia. Moreover, relatively high intakes of fat or carbohydrate compared to low protein intake result in abdominal obesity, which is defined as "sarcopenic obesity." Keeping the food-safety guidelines of COVID-19, this study recommends the consumption of fresh and healthy foods and avoiding sugar, fat, salt, alcohol, and commercially frozen foods.

• 대한지역사회영양학회지
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• 제7권6호
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• pp.833-843
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• 2002

This study was carried out to investigate the effect of hygiene education on the microbiological changes of processing utensils and the environmental in the manufacture of cereals and to evaluate the Cd, Pb contents and nutrient compositions of 11 cereals. The result of microbiological evaluation was that fungi, coliforms and staphylococcus species were detected in employees, on equipment, utensils and environments in the first inspection. Fungi were detected in most of the cereals, staphylococcus species were detected in soybeans, perilla seeds and sea tangle How, and bacillus cereus was detected in sorghum and black sesame seeds. The water content of rice, barley, glutinous rice, brown rice and carrot flour in packaged products, and in carrot flour, angelica keiskei, carrot, sea mustard and potato in bulk products was in excess of 8.0%. The Pb content of cereals was 0.14-0.51 mg/kg and Cd was not found. The acid value of Job s tears flour and black sesame seed flour was higher than 5.0 mg/g oil. Cereals were manufactured from 41 different cereals and grains, legumes, seeds and nuts, vegetables, potatoes, seaweeds, fruits, glucose and salt. The average content of cereals and grains, legumes, and seeds and nuts in cereals was 75.75%, 16.19% and 4.93%, respectively. The mean nutrient content per 100 g of cereals was calories 365.8kcal, protein 13.3 g, fats 5.9 g, carbohydrates 63.4 g, Ca 91.8 mg, p 269.9 mg, Fe 3.15 mg, Na 76.2 g, K 421.8 mg, Zn 2.33 mg, Vit. A 12.5 R.E., Vit. B$_1$0.23 mg, Vit. $B_2$ 0.16 mg, Vit. $B_6$ 0.46 mg, Niacin 3.5 mg, Vit. C 1.36 mg, folic acid 62.3 $\mu$g and Vit. E 1.24 mg. When nutrients value of 48 g of cereals and 200 $m\ell$l of milk was compared to 1/3 of the RDA, the values were below than 60% of 1/3 of the RDA except Na, K, Vitamin $B_1$ and C contents. The average carbohydrate : protein : fat ratio of energy intake was 54.27 : 17.45 : 28.28, respectively. Therefore, a training program consisting of the education of the staff in surveillance and standard operating procedures, the elimination of dangerous procedures, sanitation checklist, the implementation of Preparation methods and standard recipes for cereals is required.

• 한국식품영양과학회지
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• 제21권2호
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• pp.201-206
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• 1992

적송화분과 리기다송화분을 시료로 하여서 일반성분, 무기질, 중금속, 비타민 및 유리당을 비교 분석하였다. 적송화분은 당질 함량이 58.5%로 리기다송화분 51.8%보다 다소 높았고 그외에는 리기다송화분이 조회분 4.0%, 조단백질 15.0%, 조지방 2.5%, 조섬유 17.5% 등으로 적송화분의 조회분 2.8%, 조단백질 13.4%, 조지방 2.1%, 조섬유 14.7% 보다 높았다. 무기질의 함량은 적송화분과 리기다송화분 모두 Mg, Cl, Ca, Fe, Mn, Na, Zn등을 비교적 많이 함유하고 있었다. 독성중금속 Cd의 함량은 각각 0.3ppm였고, Pb 는 0.1 ppm, 0.2ppm, Cu는 0.3ppm, 0.7ppm, As는 0.01ppm, 0.03ppm으로 식품중의 허용기준치보다는 낮았다. 비타민 B$_1$, B$_2$, C의 함량은 적송화분 (vit. B$_1$1.2mg, vit. B$_2$1.0mg, vit. C 68.9mg)보다 리기다송화분의 함량 (vit. B$_1$, 1.6mg, vit. B$_2$1.7mg, vit. C 77.1mg)이 높았고, 비타민 E의 함량은 적송화분(1.6mg)이 리기다송화분(0.8mg) 보다 배가 높았다. 유리 당의 함량은 자당이 각각6.6%, 6.9%, 과당은 각각 0.2%, 포도당은 각각 2.1%, 2.9% 였다. 그 외의 유리당은 본 실험에서는 검출되지 않았다.

• ETRI Journal
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• 제46권3호
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• pp.526-537
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• 2024

Monitoring fetal growth in utero is crucial to anomaly diagnosis. However, current computer-vision models struggle to accurately assess the key metrics (i.e., head circumference and occipitofrontal and biparietal diameters) from ultrasound images, largely owing to a lack of training data. Mitigation usually entails image augmentation (e.g., flipping, rotating, scaling, and translating). Nevertheless, the accuracy of our task remains insufficient. Hence, we offer a U-Net fetal head measurement tool that leverages a hybrid Dice and binary cross-entropy loss to compute the similarity between actual and predicted segmented regions. Ellipse-fitted two-dimensional ultrasound images acquired from the HC18 dataset are input, and their lower feature layers are reused for efficiency. During regression, a novel region of interest pooling layer extracts elliptical feature maps, and during segmentation, feature pyramids fuse field-layer data with a new scale attention method to reduce noise. Performance is measured by Dice similarity, mean pixel accuracy, and mean intersection-over-union, giving 97.90%, 99.18%, and 97.81% scores, respectively, which match or outperform the best U-Net models.

• Journal of Oral Medicine and Pain
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• 제25권1호
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• pp.53-62
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• 2000

Bone marrow culture systems are widely used to differentiate osteoclast-like cells in vitro using several osteotropic hormones. In this study, we isolated and cultured the mouse bone marrow cells with or without some osteotropic hormones such as parathyroid hormone(PTH), prostaglandin $E_2(PGE_2)$ and $l,25(OH)_2-vitamin$ $D_3$(Vit. $D_3$). We confirmed the formation of osteoclast-like cells morphologically and functionally by the expression of tartrate-resistant acid phosphatase(TRAP) and by their capability to resorb dentin slices. We also studied the effects of transforming growth $factor-{\beta}(TGF-{\beta})$ and epidermal growth factor(EGF) on the Vit. $D_3-induced$ osteoclast-like cell formation. In control, a few multinucleated cells were formed whereas PTH and $PGE_2$ increased the number of multinucleated cells. PTH, $PGE_2$ and Vit. $D_3$ induced the formation of TRAP-positive multinucleated cells. After culture of mouse bone marrow cells on the dentin slices with or without osteotropic hormones, giant cells with diverse morphology were found on the dentin slices under the scanning electronmicroscopy. After removing the attached cells, resorption pits were identified on the dentin slices, and the shape of resorption pits was variable. EGF increased the osteoclast-like cell formation induced by Vit. $D_3$, however, $TGF-{\beta}$ showed biphasic effect, which at low concentration, increased and at high concentration, decreased the osteoclast-like cell formation induced by Vit. $D_3$.

• Biomolecules & Therapeutics
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• 제9권4호
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• pp.249-257
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• 2001

The effect of oxidative stress on the alterations of different antioxidant enzyme activities was investigated in human skin melanoma cell line (SK-MEL-2). Oxidative stress was induced by the exposure to hydrogen peroxide ($H_2O$$_2$). SK-MEL-2 cells were treated with antioxidants such as vitamin E and selenomethionine in combination with $H_2O$$_2$. SK-MEL-$_2$ cells were exposed to various concentrations of $H_2O$$_2$ and measured the time course of changes in cell viability and antioxidant enzyme activities for 24 hr. Oxidative stress was induced by the exposure to 2.5mM hydrogen peroxide ($H_2O$$_2$) resulted in declining significantly for 24 hr. GPX and CAT activities peaked at 3 hr and returned to control levels by 24 hr. On the contrary, SOD activity was inactive before 6 hr but recovered at 24 hr. In case vitamin E (Vit E) and selenomethionine (Se-Met) were used at nontoxic concentrations (25$\mu$M Vit E/500$\mu$M Se-Met) to oxidative stress was induced by the exposure to hydrogen peroxide ($H_2O$$_2$) led to a 3- and 5-fold increase on the viability comparing to control and caused an increase in GPX activity respectively.