• Title/Summary/Keyword: visual damage

Search Result 336, Processing Time 0.026 seconds

Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina

  • Park, Dae Won;Jeon, Hyelin;So, Rina;Kang, Se Chan
    • Nutrition Research and Practice
    • /
    • v.14 no.3
    • /
    • pp.203-217
    • /
    • 2020
  • BACKGROUND/OBJECTIVE: Centella asiatica, also known as Gotu kola, is a tropical medicinal plant native to Madagascar, Southeast Asia, and South Africa. It is well known to have biological activities, including wound healing, anti-inflammatory, antidiabetic, cytotoxic, and antioxidant effects. The purpose of this study was to determine the efficacy of extracts of C. asiatica against age-related eye degeneration and to examine their physiological activities. MATERIALS/METHODS: To determine the effects of CA-HE50 (C. asiatica 50% EtOH extract) on retinal pigment cells, we assessed the cytotoxicity of CoCl2 and oxidized-A2E in ARPE-19 cells and observed the protective effects of CA-HE50 against N-methyl-N-nitrosourea (MNU)-induced retinal damage in C57BL/6 mice. In particular, we measured factors related to apoptosis and anti-oxidation and the protein levels of rhodopsin/opsin. We also measured glucose uptake to characterize glucose metabolism, a major factor in cell protection. RESULTS: Induction of cytotoxicity with CoCl2 and oxidized-A2E inhibited decreases in the viability of ARPE-19 cells when CA-HE50 was administered, and promoted glucose uptake under normal conditions (P < 0.05). In addition, CA-HE50 inhibited degeneration/apoptosis of the retina in the context of MNU-induced toxicity (P < 0.05). In particular, CA-HE50 at 200 mg/kg inhibited the cleavage of pro-caspase-3 and pro-poly (ADP-ribose)-polymerase and maintained the expressions of nuclear factor erythroid 2-related factor 2 and heme oxygenase-1 similar to normal control levels. Rhodopsin/opsin expression was maintained at a higher level than in normal controls. CONCLUSION: A series of experiments confirmed that CA-HE50 was effective for inhibiting or preventing age-related eye damage/degeneration. Based on these results, we believe it is worthwhile to develop drugs or functional foods related to age-related eye degeneration using CA-HE50.

The research regarding an information system risk management process characteristics (정보시스템 위험관리 프로세스 특성에 관한 연구)

  • Kim, Tai-Dal;Lee, Hyung-Won
    • The KIPS Transactions:PartD
    • /
    • v.14D no.3 s.113
    • /
    • pp.303-310
    • /
    • 2007
  • Information system failure is various such as program test unpreparedness, physical facilities for damage prevention unpreparedness from simple software error. Although cross is trifling the result causes vast damage. Recently, became difficult by simple outside security system to solve this problem. Now, synthetic countermove establishment and suitable confrontation connected with danger came in necessary visual point about general Information Technology of enterprise. In connection with, in this paper, various informations and system and control about data that can happen information inside and outside considering integrity for IT resource, solubility, confidentiality within organization studied about special quality to model synthetic Risk Management System that can of course and cope in danger.

The Clinical Effects of Chuna Treatment in Painful Neck Disease (추나요법(推拿療法)이 경항부 통증질환에 미치는 임상적(臨床的) 효과(效果))

  • Kim, Ki-Ok;Lee, Jong-Soo
    • The Journal of Korea CHUNA Manual Medicine
    • /
    • v.1 no.1
    • /
    • pp.67-82
    • /
    • 2000
  • To clarify the effect of chuna treatment reached at neck pain, the faculties of Oriental Rehabilitation Medicine in Hospital of Oriental Medicine, Kyung Hee Medical Center had carried out chuna treatment for 72 patients who had neither structural defectiveness of cervical spine nor neural injury but simple soft tissue damage among people who visited the hospital with the neck pain since Jun. 11, 1997 to Dec. 31 in the year. The way of study: 32 out of 72 patients were treated by acupuncture treatment going with chuna treatment (calling 'Group A') and the other 40 patients were cured by only acupuncture (calling 'Group B'). The treatment in both Group A and B were performed 6 times totally at intervals of a time for 2 days. To judge the effect of treatment, both method-visual analog scale(VAS) and ,check of ROM-were performed each time. The results of study 1. Each one in Group A itself, according to the number of the treatment in progress, showed the note worthy decrease of pain and improvement of range of motion(ROM) in the cervical(P <0.001). 2. Each one in Group B itself, according to the number of the treatment in progress, showed the note worthy decrease of pain and improvement of range of motion(ROM) in the cervical(P <0.001). 3. In the degree of improvement in pain, the Group A who had been treated by both acupuncture and chuna treatment at the same lime showed some meaningful decrease in pain compared to the Group B with acupuncture treatment alone(P <0.001). 4. In the degree of improvement in ROM, the Group A who were treated by both chuna and acupuncture treatment had meaningful improvement compared to Group B who got the only acupuncture treatment(P <0.001).

  • PDF

Effects of Pre-eccentric Exercise on Exercise Induced Muscle Damage (사전 원심성 운동이 운동 유발 근 손상에 미치는 효과)

  • Kim, Byoung-Ju;Lim, Young-Eun;Yoon, Se-Won;Park, Seung-Kyu;Kim, Tae-Youl
    • The Journal of Korean Physical Therapy
    • /
    • v.20 no.1
    • /
    • pp.1-9
    • /
    • 2008
  • Purpose: This study examined the effects of pre-eccentric exercise to the quadriceps for the prevention of delayed onset muscle soreness (DOMS) and recovery of muscular function, depending on the training intensities. Methods: Subjects were divided into one of three groups that control group, a low intensity eccentric exercise group (LIEE group) and a high intensity eccentric exercise group (HIEE group). Subjects who underwent pre-eccentric exercise undertook exercise at an intensity of 25% and 75% of maximal voluntary contractions, respectively. After undertaking pre-eccentric exercise for eight weeks, eccentric exercise was applied again to induce DOMS. Measurements were conducted to examine pain and muscular function changes before, immediately after, after the induction of DOMS, and at the first, third, fifth and seventh days after the induction of DOMS. Results: Subjects who underwent pre-eccentric exercise showed a significant difference from the control group for the changes in the visual analogue scale (VAS) pain threshold, pressure pain threshold and muscle thickness by isometric contraction from measuring DOMS, and in particular, pain threshold by isometric contraction had remarkable effect in the LIEE group of subjects. For the change of the root mean square values using mechanomyography (MMG) as the measurement of muscular function recovery, subjects who had undertaken pre-eccentric exercise group showed a significant difference as compared to the control group. Conclusion: Pre-eccentric exercise was very effective in preventing and recovering delayed onset muscle soreness and was helpful to prevent and recover from decreased muscular function. The difference based on the intensity of exercise was not great, but it was more effective in the low intensity eccentric exercise group of subjects. Therefore, it can be considered that pre-eccentric exercise has a high application value as a physical therapy intervention for prevention and rehabilitation of sports injuries.

  • PDF

Techniques for Characterizing Surface Deterioration of Epoxy Exposed to Ozone Damage (오존에 노출된 에폭시 코팅재의 표면 열화특성 평가기술)

  • Choi, Sung-Min
    • Journal of the Korea institute for structural maintenance and inspection
    • /
    • v.18 no.3
    • /
    • pp.167-177
    • /
    • 2014
  • New technologies for water purification are continuously emerging to address global water quality problems, and one such technology involves advanced hermetic water purification facilities made by concrete that utilize ozone treatment processes. Better knowledge about surface deterioration of epoxy coating exposed to ozone treatment is needed as a foundation for development of improved methods and materials in the future. This study utilized atomic force microscopy (AFM), nanoindentation methods, and existing indirect methods such as visual observation, changes in mass, surface observation and chrominance analysis, to evaluate epoxy water-resistance and anti-corrosiveness. This study considered six different epoxy formulations to assess typical degradation characteristics of epoxy surfaces with regard to water-resistance/anti-corrosiveness. AFM and nanoindentation techniques emerged as promising direct methods with potential to provide quantitative measures of surface quality that are improvements upon existing indirect methods. The experiments also confirmed that some of the epoxy-coatings were severely iMPacted by ozone exposure, and thus the results demonstrate that concern about such deterioration is justified.

A Study on the Low Velocity Impact Response of Woven Fabric Composites for the Hybrid Composite Train Bodyshell (하이브리드 복합재 철도차량 차체 적용 적층판의 저속충격특성 연구)

  • Lee Jae-Hean;Cheong Seong-Kyun;Kim Jung-Seok
    • Composites Research
    • /
    • v.18 no.3
    • /
    • pp.7-13
    • /
    • 2005
  • This paper presents a study on the low velocity impact response of the woven fabric laminates for the hybrid composite bodyshell of a tilting railway vehicle. In this study, the low velocity impact tests for the three laminates with size of $100mm\times100mm$ were conducted at three impact energy levels of 2.4J, 2.7J and 4.2J. Based on the tests, the impact force, the absorbed energy and the damaged area were investigated according to the different energy levels and the stacking sequences. The damage area was evaluated by the visual inspection and the C-scan device. The test results show that the absorbed energy of [fill]8 laminate is highest whereas (fill2/warp2)s is lowest. The [fill]8 laminate has the largest damage area because of the highest impact energy absorption.

Monitoring the failure mechanisms of a reinforced concrete beam strengthened by textile reinforced cement using acoustic emission and digital image correlation

  • Aggelis, Dimitrios G.;Verbruggen, Svetlana;Tsangouri, Eleni;Tysmans, Tine;Van Hemelrijck, Danny
    • Smart Structures and Systems
    • /
    • v.17 no.1
    • /
    • pp.91-105
    • /
    • 2016
  • One of the most commonly used techniques to strengthen steel reinforced concrete structures is the application of externally bonded patches in the form of carbon fiber reinforced polymers (CFRP) or recently, textile reinforced cements (TRC). These external patches undertake the tensile stress of bending constraining concrete cracking. Development of full-field inspection methodologies for fracture monitoring are important since the reinforcing layers are not transparent, hindering visual observation of the material condition underneath. In the present study acoustic emission (AE) and digital image correlation (DIC) are applied during four-point bending tests of large beams to follow the damage accumulation. AE helps to determine the onset of fracture as well as the different damage mechanisms through the registered shifts in AE rate, location of active sources and change in waveform parameters. The effect of wave propagation distance, which in large components and in-situ can well mask the original information as emitted by the fracture incidents is also discussed. Simultaneously, crucial information is supplied by DIC concerning the moments of stress release of the patches due to debonding, benchmarking the trends monitored by AE. From the point of view of mechanics, conclusions on the reinforcing contribution of the different repair methodologies are also drawn.

Cushioning Efficiency Evaluation by using the New Determination of Cushioning Curve in Cushioning Packaging Material Design for Agricultural Products (농산물 포장용 지류완충재의 새로운 완충곡선 구현을 통한 완충성능 평가)

  • Jung, Hyun Mo
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
    • /
    • v.19 no.1
    • /
    • pp.51-56
    • /
    • 2013
  • From the time the product is manufactured until it is carried and ultimately used, the product is subjected to some form of handling and transportations. During this process, the product can be subjected to many potential hazards. One of them is the damage caused by shocks. In order to design a product-package system to protect the product, the peak acceleration or G force to the product that causes damage needs to be determined. When a corrugated fiberboard box loaded with products is dropped onto the ground, part of the energy acquired due to the action of the gravitational acceleration during the free fall is dissipated in the product and the package in various ways. The shock absorbing characteristics of the packaging cushion materials are presented as a family of cushion curves in which curves showing peak accelerations during impacts for a range of static loads are shown for several drop heights. The new method for determining the shock absorbing characteristics of cushioning materials for protective packaging has been described and demonstrated. It has been shown that cushion curves can be produced by combining the static compression and impact characteristics of the material. The dynamic factor was determined by the iterative least mean squares (ILMS) optimization technique in which the discrepancies between peak acceleration data predicted from the theoretical model and obtained from the impact tests are minimized. The approach enabled an efficient determination of cushion curves from a small number of experimental impact data.

  • PDF

Bridge Inspection and condition assessment using Unmanned Aerial Vehicles (UAVs): Major challenges and solutions from a practical perspective

  • Jung, Hyung-Jo;Lee, Jin-Hwan;Yoon, Sungsik;Kim, In-Ho
    • Smart Structures and Systems
    • /
    • v.24 no.5
    • /
    • pp.669-681
    • /
    • 2019
  • Bridge collapses may deliver a huge impact on our society in a very negative way. Out of many reasons why bridges collapse, poor maintenance is becoming a main contributing factor to many recent collapses. Furthermore, the aging of bridges is able to make the situation much worse. In order to prevent this unwanted event, it is indispensable to conduct continuous bridge monitoring and timely maintenance. Visual inspection is the most widely used method, but it is heavily dependent on the experience of the inspectors. It is also time-consuming, labor-intensive, costly, disruptive, and even unsafe for the inspectors. In order to address its limitations, in recent years increasing interests have been paid to the use of unmanned aerial vehicles (UAVs), which is expected to make the inspection process safer, faster and more cost-effective. In addition, it can cover the area where it is too hard to reach by inspectors. However, this strategy is still in a primitive stage because there are many things to be addressed for real implementation. In this paper, a typical procedure of bridge inspection using UAVs consisting of three phases (i.e., pre-inspection, inspection, and post-inspection phases) and the detailed tasks by phase are described. Also, three major challenges, which are related to a UAV's flight, image data acquisition, and damage identification, respectively, are identified from a practical perspective (e.g., localization of a UAV under the bridge, high-quality image capture, etc.) and their possible solutions are discussed by examining recently developed or currently developing techniques such as the graph-based localization algorithm, and the image quality assessment and enhancement strategy. In particular, deep learning based algorithms such as R-CNN and Mask R-CNN for classifying, localizing and quantifying several damage types (e.g., cracks, corrosion, spalling, efflorescence, etc.) in an automatic manner are discussed. This strategy is based on a huge amount of image data obtained from unmanned inspection equipment consisting of the UAV and imaging devices (vision and IR cameras).

Packaging technology of fresh-cut produce (신선편의식품 포장기술)

  • Kim, Ji Gang
    • Food Science and Industry
    • /
    • v.50 no.2
    • /
    • pp.12-26
    • /
    • 2017
  • Processing steps such as washing and cutting, involved in preparing fresh-cut produce causes tissue damage, leading to rapid quality deterioration. Major defects of fresh-cut produce are discoloration, softening, off-odor development, and microbial growth. Packaging of fresh-cut produce has been changed to reduce these quality problems. Flexible packaging film is widely used to pack fresh-cut produce. Vacuum packaging was the popular packaging method in the beginning of fresh-cut industry in Korea. Vacuum packaging creates high $CO_2$ and low $O_2$ levels to control browning of fresh-cut produce. However, these conditions induce some visual defects and off-odor development. Discoloration problem was also found when fresh-cut produce was packaged with conventional packaging film or plastic tray. Modified atmosphere (MA) packaging is effective for prolonging shelf-life of fresh-cut produce by decreasing $O_2$ and increasing $CO_2$ concentration in the package. Retail MA packaging using different oxygen transmission rate (OTR) film and micro-perforated film has started to be applied to fresh-cut produce in Korea. Proper MA package design that provides optimum range of $O_2$ and $CO_2$ partial pressures is one of the major challenges in the industry. An initial package flushing with $N_2$ or an low $O_2$/high $CO_2$ atmosphere is also used to more rapidly establish steady-state MA condition. Film OTR and $O_2$ flushing affects the fermentative volatile production, off-odor development, electrolyte leakage, discoloration, $CO_2$ injury, microbial population of fresh-cut produce. There is also a demand for convenient packaging to attract consumers. Rigid fresh-cut produce container for retail market has increased since the packaging provides excellent protection from physical damage during transport. Rigid tray used as actual serving vessel for the consumer is increasing in Korea. The tray with flexible lid to wrap or seal fresh-cut produce is more and more gaining popularity. Further practical technology to control quality change and microbial growth for each fresh-cut product has been studied since various fresh-cut items were required. The fresh-cut industry also focuses on searching for more convenient and environmentally friendly packaging.