• Title/Summary/Keyword: viscosity agent

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Formulation Design and Evaluation of Ketorolac Tromethamine Hydrogel for Transdermal Delivery System (경피흡수를 위한 케토롤락 하이드로겔의 제제설계 및 평가)

  • Cho, In-Sook;Lee, Gye-Won;Lee, Jong-Hwa;Jee, Ung-Kil
    • Journal of Pharmaceutical Investigation
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    • v.33 no.1
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    • pp.21-28
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    • 2003
  • Ketorolac tromethamine(KT) is a nonsteroidal agent with potent analgesic and moderate anti-inflammatory activity. The lipid-water partition coefficient of KT was evaluated and KT gel was formulated as a gel containing different pH, different concentrations of polymer (poloxamer 407, carbopol 941), propylene glycol, ethanol and various enhancers. The resulting KT gels were evaluated with respect to their viscosity, in vitro drug permeation rate through hairless mouse skin and stability. In n-octanol and chloroform, the lipid-water partition coefficient of KT was the highest at pH 4 phosphate buffer. The apparent viscosity of KT gel increased with an increase in gel pH, polymer and enhancer concentration. But the apparent viscosity of KT gel decreased with an increase in ethanol concentration. The permeation rate of KT through hairless mouse skin from gels different pH was maximum at pH 4 which is close to KT $pK_{a}$ 3.54. The permeation rate decreased with an increase in polymer, propylene glycol concentration. But the permeation rate increased with an increase in ethanol. The increase of drug concentration from 1 to 3% induced linear increase in permeation rate. The best enhancer was the combination of $Labrasol^{\circledR},\;Transcutol^{\circledR}$, oleic acid and l-menthol. In the accelerated stability test(25, 40 and $50{\circ}C$), pH 5 gel was most stable and pH 4 gel was most unstable for 90 days.

A Study on the Factors Affecting the High Fluid Mortar Containing Ground Granulated Blast-furnace Slag (고로슬래그 미분말을 함유한 고유동 모르터의 유동성상에 미치는 영향 요인에 관한 연구)

  • Kim, Jae-Hun;Yoon, Sang-Chun;Jee, Nam-Yong
    • Journal of the Korea Institute of Building Construction
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    • v.2 no.4
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    • pp.145-152
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    • 2002
  • High fluid concrete unlike OPC concrete is made with various material, and the phase of fresh concrete is considerably different. In order to understand fluidity phase and mix properties of high fluid concrete, concrete is required to access as suspension structure which consists of aggregate and paste. The focus of this paper is to analyze the test results and quantify the effect of mix proportions of mortar and fineness modulus of sand on the properties of fresh mortar. The effect of water-binder ratio. sand-binder ration. contents of ggbs (by mass of total cementitious materials). and various contents of water reducing agent on the yield stress and plastic viscosity of the mix is studied. Based on the experimental results, the fellowing conclusions can be drawn: (1) The mixing time needed for high fluid mortar was approximately two times more than that of ordinary portland mortar. (2) The fluidity phase of mortar could be explained by yield stress of mix and the fluidity of mortar. (3) As the content of ggbs increased, yield stress of mortar was decreased and plastic viscosity of it was increased. (4) For the high fluid mortar, it was appeared that sand-binder ratio should be below 1.5.

Study on Mixing Condition of the Rubber Composite Containing Functionalized S-SBR, Silica and Silane : I. Effect of Mixing Temperature (변성 S-SBR Silica-Silane 고무복합체의 배합조건에 대한 연구 : I. 배합온도의 영향)

  • Jang, Suk-Hee;Kim, Wook-Soo;Kang, Yong-Gu;Han, Min-Hyun;Chang, Sang-Mok
    • Elastomers and Composites
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    • v.48 no.2
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    • pp.94-102
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    • 2013
  • Characteristics of rubber mixture were evaluated in order to find the optimum mixing conditions of compounds containing silica and silane at various temperatures. With different mixing temperatures of 105, 120, 130, 140 and $160^{\circ}C$, the viscosity of the compound mixed at $105^{\circ}C$ showed a very high viscosity value. Compounds mixed the temperature range from at $120^{\circ}C$ to $140^{\circ}C$ showed lower viscosity than the compound mixed at $105^{\circ}C$. However, the difference was found to be small in those temperature ranges. On the contrary, at the mixing temperature of $160^{\circ}C$, the viscosity of compound increased again. Through the physical and dynamic observations, it was verified that at the mixing temperature below $120^{\circ}C$ only insufficient silica-silane reaction has been obtained. In addition, with the elevated mixing temperature of $160^{\circ}C$, Cross-linking occurred during mixing by the sulfur contained in coupling agent. In the temperature ranges from $120^{\circ}C$ to $140^{\circ}C$, because of the fast coupling reaction at higher temperature, it was thought to be more advantageous during reaction even though the trend of viscosity and dynamic mechanical property was not clear.

A Study on Adhesion Characteristics and Physical Properties of Animal Glue Added Genipin (제니핀을 첨가한 아교의 접착 특성과 물성 변화 연구)

  • Lee, Jun Ho;Yu, Ji A;Chung, Yong Jae
    • Journal of Conservation Science
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    • v.34 no.3
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    • pp.157-166
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    • 2018
  • In this study, gelatin binding ability was increased by adding cross linking agent to improve adhesive characteristic of animal glue. Animal glue added genipin measured gel strength and viscosity, the structural analysis, the color retention degree, elution degree, and rupture strength. And the water resistance and ultraviolet light resistance with the addition of genipin were compared. As a result of the study, the gel strength and viscosity increased with the amount of genipin. As a result of the structural analysis, in gelatin, the absorption peak of the triple structure of collagen structurally stabilized was observed. As a result of the color retention degree, the film was observed because of the lowered brightness. The amount of elution glue was increased with addition of genipin at $50^{\circ}C$ distilled water condition and rupture strength has increased with the amount of genipin. In the water resistance and light fastness, there was no appearance before and after deterioration due to the addition of genipin. Based on the results of this study, it confirmed the adhesive characteristics of animal glue added genipin and examined the experimental method applicable for animal glue. After the addition of genipin, flexibility, re-solving, adhesive force, and curing speed, which are unique characteristics of glue, can be improved without disappearing, so it is expected that it will be applicable to production of animal glue and conservation of cultural heritage when homogeneous glue is secured.

Study on the Non-isothermal Crystallization Kinetics of Branched Polypropylene (분지형 폴리프로필렌의 비등온결정화 거동 연구)

  • Yoon, Kyung-Hwa;Shin, Dong-Yup;Kim, Youn-Cheol
    • Polymer(Korea)
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    • v.36 no.2
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    • pp.245-250
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    • 2012
  • Branched polypropylenes (PP) with long chain branch were prepared by solid state reaction with three different branching agent of 0.3 wt% content. The chemical structures, non-isothermal crystallization behavior and complex viscosity of the branched PP were investigated by FTIR, DSC, optical microscope, and dynamic rheological measurement. The chemical structure of the branched PP was confirmed by the existence of =C-H stretching peak of the branching agent at 3100 $cm^{-1}$. There was no distinct change in melting temperature in case of PP-D-0-3 and PP-F-0-3, but PP-H-0-3 indicated a decrease in melting temperature. The decrease in melting temperature was interpreted by the fact that the degradation reaction of PP was more dominant than branched reaction, and confirmed by a decrease in complex viscosity. The non-isothermal crystallization behavior of the branched PP was analyzed using by Avrami equation. The Avrami exponent of PP was 3, and the values of the branched PP with DVB and FS were below 3. The activation energy of PP calculated by Kissinger method was 25 kJ/mol, and there were no big difference in activation energies of the branched PPs compared to PP.

Study on Bleaching Effect of Neutralization Agent (Sodium Meta Silicate and Triethylamine) Regarding Its Concentration - Focused on 10% Urea Hydrogen Peroxide Bleaching Gel - (도자기 표면 변색에 대한 중화제(Sodium Meta Silicate 및 Triethylamine)의 농도별 표백 효과 - 10% 과산화요소 표백겔을 중심으로 -)

  • Ham, Chul Hee
    • Korean Journal of Heritage: History & Science
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    • v.44 no.4
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    • pp.130-141
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    • 2011
  • This paper examined the bleaching effect of the two types of gel made with neutralizing agent such as sodium meta silicate gel & triethylamine gel mixed with carbopol resin 940 & 934 which has thickness effect in broad pH region and mixed with 10% hydrogen peroxide. Sodium meta silicate gel(1.6g included) provided pH 10, the most suitable environment for bleaching. The result of comparison of the baseline colour changes(${\Delta}E*ab$) and colour changes according to time(${\Delta}E*ab$) is as following. Group1(carbopol 940, sodium meta silicate, Urea Hydrogen Peroxide) showed 112% efficiency at CS-2; 63.3% at CS-4; 87.4% at CS-6. Group2(carbopol 934, sodium meta silicate, Urea Hydrogen Peroxide) showed 77.3%, 67.3%, 109.6% at CS-8, CS-10, CS-12 respectively; CT-1, CT-3, CT-5 of Group3(carbopol 940, triethylamine, Urea Hydrogen Peroxide) showed 36.8%, 73.2%, 74%; In Group4(carbopol 934, triethylamine, Urea Hydrogen Peroxide), efficiency of CT-6, CT-8, and CT-10 was 81.7%, 95.4%, and 95.7%. The paper showed that various concentration of neutralizing agent such as sodium meta silicate and triethylamine have bleaching effect. Viscosity of the gel including sodium meta silicate was higher than the gel including triethylamine. High viscosity helps the bleaching gel sit on the smooth slope of the ceramics. As a result, sodium meta silicate is considered to provide thickening and bleaching effect required in producing 10% hydrogen peroxide gel.

Evaluation of Manufacturing and Biological Properties of Y Zone Care Hydrogel Solution (Y존 케어 하이드로젤솔루션의 제조 및 생물학적 특성 평가)

  • Eun-Ji Kim;In-Kyoung Kim
    • Journal of Advanced Technology Convergence
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    • v.3 no.2
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    • pp.25-31
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    • 2024
  • In recent industrialization and development due to information and communication technology, modern women in modern society are exposed to physical and mental health due to numerous stresses. Popular inflammations are attributable to a decrease in lactic acid bacteria, frequent antibiotic use, and a decrease in immunity. It is necessary to develop products that are helpful and reflected. The inner care gel currently introduced on the market can increase beneficial bacteria and maintain a healthy y-zone. The inner gel contains a hydrogel component. 90% is made up of water, and other components act as support for supporting water and are formed through crosslinking between polymer chains. Hydroxyethyl cellulose (HEC) is a hydroxyethyl ethylenetel of cellulose. The purpose of use is to act as a binder, an emulsion stabilizer, a viscosity enhancer (water-soluble), and a film forming agent. CA (crosslinker) is a crosslinking agent and serves to bind. Hydrogel in the beauty field acts as a film forming agent that gently wraps around the skin by forming a thin film and serves as an emulsion stabilizer that helps to prevent separation of other raw materials. It also acts as a thickener by increasing viscosity in cosmetics. In addition, it is used for glucose monitoring, nursing care, cell transplantation, and wound treatment in the bio field. Currently, it is understood that no products using functional hydrogel have been released, so in this study, a Y zone care hydrogel solution was manufactured to find out the antibacterial properties of the functional hydrogel, and a new solution was developed. As a result, it was confirmed that the appropriate Ph was applied to the Y zone, and after culturing Candida albicans in PDB medium, all three products of the Y zone care hydrogel solution showed an antibacterial effect of 0.5-1.0mm

Influence of Foaming Agents on the Properties of Foamed Concretes Having Various Densities

  • Kim, Jin-Man;Jeong, Ji-Yong
    • Journal of the Korea Institute of Building Construction
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    • v.12 no.1
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    • pp.22-30
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    • 2012
  • Four types of foaming agents, including Alcohol Ethoxy Sulfate (AES), Alpha Olefin Sulfonate (AOS), Vegetable Soap (VS), and Fe-Protein (FP), are widely used in the construction field. These have different surface tensions and viscosities in water of the same concentration, affecting the flow speed of liquid, size and distribution of foam, and foam stability. However, there is a lack of data regarding the properties of foam concrete using various foam agents. The purpose of this study is to investigate influence of foaming agents on the properties of foamed concretes with various densities. We find that the foaming agent type has little effect on the density, compressive strength, and thermal conductivity of foam concrete, but considerably affects the unit weight of foam, flow and flexural strength of foamed concrete. While almost all properties of foam concrete are affected by density in fresh or hardened state, the potential energy changed by slurry density and the viscosity of foam are dominant factors in the flowability of foam slurry.

Quality Characteristics of Snow Crab Cream Soup with Yam and Potato as a Thickening Agents (참마와 감자를 농후제로 사용한 홍게 크림수프의 품질 특성)

  • Oh, Young-Sub
    • Culinary science and hospitality research
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    • v.13 no.1 s.32
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    • pp.112-118
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    • 2007
  • This study was carried out to investigate the quality characteristics of snow crab cream soup in order to seek the possibility of using fresh yams and potatoes instead of roux as thickening agents. The highest crude lipid(p<.05) and moisture(p<.001) were examined for the snow crab cream soup with yams and with potatoes as thickening agents($S_1$),($S_2$). The highest pH levels of $S_2(5.75)$ for the snow crab cream soup with yams and with potatoes were 75% and 25%. respectively. The highest lightness of 71.51(L value) was found in the 100% potato as a thickening agent($S_5$)(p<.001). The redness(a value) and yellowness(b value) were increased by adding potatoes to the snow crab soup(a=p<.001), (b=p<.01). Viscosity was increased by potato contents, and highest for the snow crab cream soup($S_5$) (p<.001). In sensory evaluation, the highest sensory scores for flavor and texture(p<.001) of mean 5.11 and 5.05, respectively, were obtained from the snow crab cream soup with yams(75%) and with potatoes(25%)($S_4$). The highest overall acceptability of mean 5.11 was found in the snow crab cream soup with yams(50%) and with potatoes(50%) as thickening agents($S_3$)(p<.001).

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Preparation and Physical Properties of PU Flame-Retardant Coatings Using Benzoic Acid Modified Polyester Containing Phosphorus and HDI-Trimer (인 함유 벤조산 변성폴리에스테르와 HDI-Trimer에 의한 PU 난연도료의 제조 및 도막물성)

  • Lee, Ae-Ri;You, Hyuk-Jae;Chung, Dong-Jin;Hahm, Hyun-Sik;Park, Hong-Soo
    • Journal of the Korean Applied Science and Technology
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    • v.21 no.1
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    • pp.62-68
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    • 2004
  • PU flame-retardant coatings (APHD) containing phosphorous were prepared by blending of hexamethylene diisocyanate-trimer, white pigment, dispersing agent, flowing agent, and previously prepared benzoic acid modified polyester (APTB) that contains phosphorous. Physical properties of the prepared APHD were examined. With the introduction of BZA (contained in APTB), the film viscosity and film hardness of APHD decreased. With the introduction of caprolactone group, the flexibility, impact resistance, accelerated weathering resistance of APTBs increased. Flame retardancy of the coatings was tested. In a vertical burning method, APHD shows 210${\sim}$313 seconds, and in a $45^{\circ}$ Meckel burner method, shows 1.3${\sim}$4.0$cm^2$ of char length, which indicates that the coatings are good flame-retardant coatings. Moreover, the amount of afterglow and flame retardancy of the coatings are decreased with increasing BZA content.