• Title/Summary/Keyword: vehicle component

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인진호탕합시호소간탕가감방(茵陳蒿湯合柴胡疏肝湯加減方)이 간손상(肝損傷)에 미치는 영향(影響) (The effects of Injinhotang-sihosogantang-gagambang on liver injury)

  • 김태식;강재춘
    • 대한예방한의학회지
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    • 제3권2호
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    • pp.183-210
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    • 1999
  • In order to investigate the protective effect of Injinhotanghapsihosogantang-gagambang on the liver injury of rats induced by $CCl_4$ and d-galactosamine, the serum transaminase(GOT&GPT) alkaline phosphatase(ALP), lactic dehydrogenase(LDH) for enzyme activities, triglyceride for serum component, liver weight and glutathione S-transferase(GST), Superoxide dimutase(SOD) were measured. All animals were divided into 5 groups, those were normal group(untreated), control group(treated with vehicle 0.9% Saline solution), sample I group(10mg/kg administrated), sample II group(30mg/kg administrated), Silymarin 200 administrated group. The results were as follows: 1. The inhibitory effects of the serum GOT activities in rats induced by $CCl_4$ were noted in both sample I (p<0.001) and sample II group(p<0.001). In serum GPT activities, sample I (p<0.01) and sample II group(p<0.01). 2. The inhibitory effects of the serum LDH activities in rats induced by $CCl_4$ were noted in both sample I (p<0.001) and sample II group(p<0.001). 3. The increased effects of the serum ALP activities in rats induced by $CCl_4$ were not recognized. 4. The inhibitory effects of the serum triglyceride content level in rats induced by $CCl_4$ were inhibited in only sample II group(p<0.05). 5. The increased effects of the liver weight level in rats induced by $CCl_4$ were inhibited in both sample I (p<0.05) and sample II group(p<0.05). 6. The inhibitory effects of the GST activities in rats induced by $CCl_4$ were not recognized. In SOD activities, both sample I (p<0.05) and sample II group(p<0.001) showed the inthbitory effects. 7. The inhibitory effects of in the serum GOT, GPT activities in rats induced by d-galactosamine were not recognized. 8. The increases of the serum LDH level in rats induced by d-galactosamine were noted in both sample I (p<0.01) and sample II group(p<0.001). 9. The inhibitory of the serum triglyceride content level in rats induced d-galactosamine were noted in only sample II group(p<0.05). According to the above results, it is considered that Injinhotanghapsihosogantang-gagambang has protective effect against liver injury in rats induced by $CCl_4$ and d-galactosamine.

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삼두해정탕이 사염화탄소(四鹽化炭素) 및 d-Galactosamine에 의(依)하여 유발(誘發)된 실험적(實驗的) 흰쥐의 간손상(肝損傷)에 미치는 영향(影響) (The effects of Samduhaejungtang on liver injury of rats induced by $CCl_4$ and d-galactosamine)

  • 강재춘;송호림
    • 대한한방내과학회지
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    • 제19권1호
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    • pp.39-56
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    • 1998
  • In order to investigate the protective effect of Samduhaejungtang on the liver injury of rats induced by $CCl_4$ and d-galactosamine, the serum transaminase(GOT& GPT), alkaline phosphatase(ALP), lactic dehydrogenase(LDH) for enzyme activities and triglyceride, total bilirubin amounts for serum component were measured. All animals were divided into 4 groups, those were normal group(untreated), control group(treated with vehicle 0.9% Saline solution), sample Ⅰ group(1000mg/kg administrated), sample Ⅱ group(2000mg/kg administrated). The results were as follows : 1. The inhibitory effects of the serum GOT activities in rats induced by $CCl_4$ were noted in both sample Ⅰ group(p<0.01) and sample Ⅱ group(p<0.001). In serum GPT activities, sample Ⅱ group(p<0.05) only showed the inhibitory effects. 2. The inhibitory effects of the serum ALP activities in rats induced by $CCl_4$ were noted in both sample Ⅰ group(p<0.01) and sample Ⅱ group(p<0.001). 3. The inhibitory effects of the serum LDH activities in rats induced by $CCl_4$ were noted in sample Ⅱ group(p<0.05). 4. The increases of the serum triglyceride content level in rats induced by $CCl_4$ were inhibited in both sample Ⅰ group(p<0.01) and sample Ⅱ group(p<0.001). 5. The increases of the serum total bilirubin content level in rats induced by $CCl_4$ were inhibited in both sample Ⅰ group(p<0.01) and sample Ⅱ group(p<0.001). 6. The inhibitory effects of the serum GOT& GPT activities in rats induced by d-galactosamine were noted in sample Ⅱ group(p<0.001), but sample Ⅰ group was not recongnized. 7. The significantly inhibitory effects of in the serum LDH activities in rats induced by d-galactosamine were note in sample Ⅱ group(p<0.05). 8. The increases of the serum triglyceride content level in rats induced by d-galactosamine were inhibited in sample Ⅱ group(p<0.01). 9. The increases of the serum total bilirubin content level in rats induced by d-galactosamine were inhibited in sample Ⅱ group(p<0.05). According to the above results, it is considered that Samduhaejungtang has protective effect against liver injury in rats induced by $CCl_4$ and d-galactosamine.

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The Dynamics of Noise and Vibration Engineering Vibrant as ever, for years to come

  • Leuridan, Jan
    • 한국소음진동공학회:학술대회논문집
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    • 한국소음진동공학회 2010년도 춘계학술대회 논문집
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    • pp.47-47
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    • 2010
  • Over the past 20 years, constant progress in noise and vibration (NVH) engineering has enabled to constantly advance quality and comfort of operation and use of really any products - from automobiles to aircraft, to all kinds of industrial vehicles and machines - to the extend that for many products, supreme NVH performance has becomes part of its brand image in the market. At the same time, the product innovation agenda in the automotive, aircraft and really many other industries, has been extended very much in recent years by meeting ever more strict environmental regulations. Like in the automotive industry, the drive towards meeting emission and CO2 targets leads to very much accelerated adoption of new powertrain concepts (downsizing of ICE, hybrid-electrical...), and to new vehicle architectures and the application of new materials to reduce weight, which bring new challenges for not only maintaining but further improving NVH performance. This drives for innovation in NVH engineering, so as to succeed in meeting a product brand performance for NVH, while as the same time satisfying eco-constraints. Product innovation has also become increasingly dependent on the adoption of electronics and software, which drives for new solutions for NVH engineering that can be applied for NVH performance optimization of mechatronic products. Finally, relentless pressure to shorten time to market while maintaining overall product quality and reliability, mandates that the practice and solutions for NVH engineering can be optimally applied in all phases of product development. The presentation will first review the afore trends for product and process innovation, and discuss the challenges they represent for NVH engineering. Next, the presentation discusses new solutions for NVH engineering of products, so as to meet target brand values, while at the same time meeting ever more strict eco constraints, and this within a context of increasing adoption of electronics and controls to drive product innovation. NVH being very much defined by system level performance, these solutions implement the approach of "Model Based System Engineering" to increase the impact of system level analysis for NVH in all phases of product development: - At the Concept Phase, to be able to do business case analysis of new product concepts; to arrive at an optimized and robust product architecture (e.g. to hybrid powertrain lay-out, to optimize fuel economy); to enable target cascading, to subsystem and component level. - In Development Phase, to increase realism and productivity of simulation, so as to frontload virtual validation of components and subsystems and to further reduce reliance on physical testing. - During the final System Testing Phase, to enable subsystem testing by a combination of physical testing and simulation: using simulation models to simulate the final integration context when testing a subsystem, enabling to frontload subsystem testing before final system integration is possible. - To interconnect Mechanical, Electronical and Controls engineering, in all phases of development, by supporting model driven controls engineering (MIL, SIL, HIL). Finally, the presentation reviews examples of how LMS is implementing such new applications for NVH engineering with lead customers in Europe, Asia and US, with demonstrated benefits both in terms of shortening development cycles, and/or enabling a simulation based approach to reduce reliance on physical testing.

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도심지 공사시 지하안전 확보를 위한 기술개발 동향 (Technological Development Trends for Underground Safety in Urban Construction)

  • 백용;김우석
    • 터널과지하공간
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    • 제27권6호
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    • pp.343-350
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    • 2017
  • 최근 도심지 지상공간의 포화로 전세계적으로 지하공간개발이 활발히 진행되고 있으며, 지상 및 지하구조물에 인접하여 굴착이 많이 이루어지고 있다. 굴착공사 중 시공 부주의나 시공기술 미흡, 지하수 유출, 급격한 지층의 변화, 토류 시스템 구성품의 문제 등으로 인해 각종 지반함몰 사고가 발생하여 사회적 이슈로 부각되고 있다. 국가적으로 이를 대응하기 위하여 도심지 지하 시설물에 대한 예방중심의 선제적 재난 재해 관리 및 신속 복구 시스템 구축을 추진 중에 있다. 본 연구에서는 굴착공사 시 지반 내부적인 변화 요소(지하수위 변화, 지하매설물 손상 등)와 외부적인 변화요소(차량하중, 지진, 지반굴착 등)를 고려한 지하안전 확보를 위한 기술개발 동향에 대하여 자료를 수집하였다. 지반거동 해석 및 지반함몰 평가기술과 지반함몰 예방을 위한 안전한 굴착 및 보강기술, 지반함몰 발생시 긴급복구 기술의 개선 및 국내 자립화가 요구되고 있는 가운데 현재 도심지 굴착공사시 지반함몰 예방을 위한 기술개발 현황에 대하여 소개하고자 한다. 현재 연구가 진행되고 있는 부분도 있으나 크게 분류하여 예측/평가기술, 복합탐사기술, 차수보강기술, 긴급복구기술, 굴착기술의 5개 분야로 설명하고자 한다.

삼두해정탕가미방이 $CCl_4$ 및 d-Galactosamine에 依하여 誘發된 흰쥐의 肝損傷에 미치는 影響 (The effects of Samduhaejungtang-gamibang on liver injury of rats induced by $CCl_4$ and d-Galactosamine)

  • 강재춘;이상민
    • 대한한방내과학회지
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    • 제20권1호
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    • pp.181-197
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    • 1999
  • In order to investigate the protective effect of Samduhaejungtang-gamibang on the liver injury of rats induced by $CCl_4$ and d-galactosamine, the serum transaminase(GOT& GPT) alkaline phosphatase(ALP), lactic dehydrogenase(LDH) for enzyme activities and triglyceride, total bilirubin amounts for serum component were measured. All animals were divided into 4 groups, those were normal group(untreated), control group(treated with vehicle 0.9% Saline solution), sample Ⅰ group(1500mg/kg administrated), sample Ⅱ group(3000mg/kg administrated). The results were as follows: 1. The inhibitory effects of the serum GOT activities in rats induced by $CCl_4$ were noted in sample Ⅱ group(p<0.01). In serum GPT activities, sample Ⅱ group(p<0.05) only showed the inhibitory effects. 2. The inhibitory effects of the serum ALP activities in rats induced by $CCl_4$ were noted in sample Ⅱ group(p<0.01) 3. The inhibitory effects of the serum LPH activities in rats induced by $CCl_4$ were noted in sample Ⅱ group, but it is not recognized statistically. 4. The increases effects of the serum triglyceride content level in rats induced by $CCl_4$ were inhibited in both sample Ⅰ group(p<0.05) and sample Ⅱ group(p<0.01) 5. The increases effects of the serum total bilirubin content level in rats induced by $CCl_4$ were inhibited in sample Ⅱ group(p<0.05) 6. The inhibitory effects of the serum GOT, GPT activities in rats induced by d-galactosamine were noted in sample Ⅱ group (p<0.001), but sample Ⅰ group was not recognized. 7. The signiticantly inhibitory effects of in the serum LDH activities in rats induced by d-galactosamine were noted in both sample Ⅰ group(p<0.05) and sample Ⅱ group (p<0.001) 8. The increases of the serum ALP content level in rats induced by d-galactosamine were inhibited in sample Ⅱ group(p<0.05) 9. The increases of the serum total bilirubin content level in rats induced d-galactosamine were inhibited in sample Ⅱgroup(p<0.05) According to the above results, it is considered that Samduhaejungtang-gamibang has protective effect against liver injury in rats induced by $CCl_4$ and d-galactosamine. So it is required to study about the actions of mutual relation of medicines and patho-mechanism by experiment.

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Single Oral Dose Toxicity Study of Aqueous Extracts of Binso-san in ICR Mice

  • Park, Kyung;Kim, Dae-Jun;Byun, Joon-Seok
    • 동의생리병리학회지
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    • 제24권1호
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    • pp.134-142
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    • 2010
  • Although BinSo-San(BSS), a mixed herbal formula consisted of 11 types of medicinal herbs and have been used as anti-inflammatory agent, In the present study, the acute toxicity (single oral dose toxicity) of lyophilized BSS aqueous extracts was monitored in male and female mice after oral administration according to Korea Food and Drug Administration (KFDA) Guidelines (2005-60, 2005). In order to observe the 50% lethal dose ($LD_{50}$), approximate lethal dosage (ALD), maximum tolerance dosage (MTD) and target organs, test articles were once orally administered to female and male ICR mice at dose levels of 2000, 1000, 500, 250 and 0 (control) mg/kg (body wt.) according to the recommendation of KFDA Guidelines (2005-60, 2005). The mortality and changes on body weight, clinical signs and gross observation were monitored during 14 days after dosing according to KFDA Guidelines (2005-60, 2005) with organ weight and histopathology of 12 types of principle organs. We could not find any mortality, clinical signs and changes in the body weights except for dose-independent increases of body weight and gains restricted in 1000 mg/kg of BSS extracts-dosing female group. Hypertrophic changes of lymphoid organs.thymus, spleen and popliteal lymph nodes were detectedat postmortem observation with BSS extracts dose-dependent increases of lymphoid organ weights, and hyperplasia of lymphoid cells in these all three lymphoid organs at histopathological observations. These changes are considered as results of pharmacological effects of BSS extracts or their components, immunomodulating effects, not toxicological signs. In addition, some sporadic accidental findings such as congestion spots, cyst formation in kidney, atrophy of thymus and spleen with depletion of lymphoid cells, and edematous changes of uterus with desquamation of uterus mucosa as estrus cycles were detected throughout the whole experimental groups including both male and female vehicle controls. The significant (p<0.01) increases of absolute weights of kidney and pancreas detected in BSS extracts 1000 mg/kg-treated female group are considered as secondary changes from increases of body weights. The results obtained in this study suggest that the BSS extract is non-toxic in mice and is therefore likely to be safe for clinical use. The LD50 and ALD of BSS aqueous extracts in both female and male mice were considered as over 2000 mg/kg because no mortalities were detected upto 2000 mg/kg that was the highest dose recommended by KFDA and OECD. In addition, the MTD of BSS extracts was also considered as over 2000 mg/kg because no BSS extracts-treatment related toxicological signs were detected at histopathological observation except for BSS or their component-related pharmacological effects, the immunomodulating effects detected in the present study.

주행모드에서 사용연료에 따른 자동차의 $CO_2$ 배출특성과 연료소비율의 상관관계 비교 분석 (Relationship between $CO_2$ emission and fuel consumption rate according to used fuels at driving mode)

  • 김용태;이호길;강정호;한성빈;정연종
    • 에너지공학
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    • 제17권4호
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    • pp.227-232
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    • 2008
  • 이산화탄소는 지구온난화를 일으키는 온실가스의 하나의 주요요인으로 생각되어진다. $CO_2$는 탄화수소를 연료로 사용하는 연소에서 배기가스의 주성분이다. 자동차의 $CO_2$ 배출물에 대한 규제는 최근에 더욱 절박하게 대두되어 왔다. 이러한 심각한 규제는 배기가스를 저감하는 대체연료를 개발할 수 있는 자동차 제품들에게 요구되는 것이다. 본 논문은 가솔린, 디젤, LPG 자동차를 사용하여, FTP-75와 NEDC(ECE15+EUDC) 모두에 따라서 $CO_2$ 배출물과 연료소비율(연비)과의 상관관계를 검토했다. 이 논문을 통해서 탄소중량비가 낮은 연료 일수록 $CO_2$ 발생량의 감소율이 큰 것을 알 수 있다. 사용한 연료에 따라서 $CO_2$ 배출량과 연비와의 관계를 함수로 표현할 수 있었으며, 높은 상관관계를 갖는 것을 알 수 있었다. LPG차량은 휘발유와 디젤차량보다 $CO_2$ 배출량이 적게 배출되는 것을 알 수 있었다.

제2형 당뇨병 모델 마우스에서 ginsenoside Rg1의 항당뇨 효과 (Antihyperlipidemic Effect of Ginsenoside Rg1 in Type 2 Diabetic Mice)

  • 박재홍;이지연;여지영;남정수;정명호
    • 생명과학회지
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    • 제21권7호
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    • pp.932-938
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    • 2011
  • Ginsenoside Rg1은 인삼에서 분리한 약물학적인 활성을 가지는 물질이다. 본 연구는 Rg1이 제2형 당뇨병 모델 동물에서 혈당과 지질대사에 유익한 효과를 가지는지를 확인하기 위한 목적으로 수행되었다. 10주령의 db/db 마우스에 Rg1을 10 mg/kg 농도로 15일간 경구투여한 결과 공복혈당이 감소하였고, 포도당 내성이 개선되었다. 특히 혈중 중성지방과 유리지방산이 유의적으로 감소하였고 혈중 HDL-콜레스테롤이 증가되었다. 또한 chimeric GAL4-PPAR${\alpha}$ receptor 활성 프로모터를 활성화시켰고 PPAR${\alpha}$ gene인 CPT-1 (carnitine palmitoyltransferase-1)과 ACO (acyl-CoA oxidase)의 발현을 증가시켰는데 이것으로 Rg1의 지질대사 개선이 PPAR${\alpha}$ 활성에 의한 지방산 산화에 의한 것임을 확인할 수 있었다. 모든 결과를 종합해 볼 때, Rg1은 제2형 당뇨병과 관련된 고혈당증과 고지혈증에 유용한 효과를 가짐을 확인하였다.

가속도 계측 자료를 이용한 콘크리트 교량의 처짐 산정 (Calculation of Deflection Using the Acceleration Data for Concrete Bridges)

  • 윤영균;유희중
    • 한국구조물진단유지관리공학회 논문집
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    • 제15권5호
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    • pp.92-100
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    • 2011
  • 본 연구는 실제 교량에서 차량 주행에 따른 가속도 계측 자료를 이용하여 교량의 고유진동수를 진동 모드별로 파악한 후, 수치 모델링을 통하여 유도된 동적하중에 따른 6차 모드까지의 고유진동수를 고려하여 처짐을 계산할 수 있는 산정식에 관한 것이다. 처짐 계산식은 모드중첩법에 의한 비감쇠 강제진동 이론을 이용하여 교량을 등속도로 이동하는 동적 주행하중에 의해 발생하는 처짐을 계산할 수 있도록 수치 모델링을 하였으며, 이를 검증하고 자동으로 계산할 수 있도록 하였다. 그리고, 제안된 처짐 계산식을 검증하기 위하여 콘크리트 교량을 대상으로 동적재하시험을 실시하여 처짐을 측정하고 이 값을 본 연구의 처짐 계산식의 결과와 비교하여 정확성 및 타당성 검증을 실시하였다. 이 결과, 본 연구에서 제시하는 처짐 계산식은 고유진동수를 고려하는 진동모드의 차수가 낮은 경우에 비교적 정확한 처짐을 예측하며, 주행속도에 따라서는 적용하는 진동 모드 차수에 의하여 처짐 예측의 정확도가 영향을 받는 것을 확인하였다. 그리고, 주행속도가 비교적 빠른 경우에 한하여 본 연구에서 제시하는 처짐 계산식은 진동 모드에 상관없이 비교적 정확하고 신뢰도가 양호한 계산 결과를 얻을 수 있는 것으로 나타났다.

전동 조향 장치용 브러쉬리스 영구자석 전동기의 스테이터 스큐 설계 (Design of Brushless Permanent Machine with Skewed Stator for Electrical Power Steering System)

  • 이충성;정경태;홍정표;김해중;김영균
    • 한국자기학회지
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    • 제25권6호
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    • pp.189-197
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    • 2015
  • 최근 차량의 연비규제 강화로 인해, 기존 내연기관의 차량 부품 구동방식이 유압방식 대신 전동방식으로 대체되어 가고 있다. 이러한 부품의 대표적인 예가, Electronic Power Steering(EPS)이며, 현재 대부분의 차량에 적용되고 있다. EPS의 핵심 부품으로서는 전동기가 있으며, EPS의 조향감 개선 및 진동/소음 저감을 위해 전동기의 Cogging torque 및 Torque Ripple 저감이 요구된다. 일반적으로 Cogging torque 및 Torque ripple을 저감하기 위해서, 고정자 또는 회전자에 스큐를 적용한다. 본 연구에서는 고정자에 스큐가 적용된 Bushless PMSM(Permanent Magnet Synchronous Motor)의 설계 방법 및 해석방법에 대해 소개한다. 고정자 skew가 적용된 EPS용 PMSM에 대해 초기 설계를 진행하고, RSM(Response Surface Methodology)을 이용한 최적설계를 수행한다. 유한요소해석을 통해 역기전력, Inductance, Load torque 등의 성능을 확인한다. 마지막으로 시제품 제작 및 실험을 통해 설계 방법에 대한 신뢰성을 검증한다.