Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Antihyperlipidemic Effect of Ginsenoside Rg1 in Type 2 Diabetic Mice

제2형 당뇨병 모델 마우스에서 ginsenoside Rg1의 항당뇨 효과

  • Park, Jae-Hong (School of Korean Medicine, Pusan National University) ;
  • Lee, Ji-Youn (School of Korean Medicine, Pusan National University) ;
  • Yeo, Ji-Young (School of Korean Medicine, Pusan National University) ;
  • Nam, Jeong-Su (School of Korean Medicine, Pusan National University) ;
  • Jung, Myeong-Ho (School of Korean Medicine, Pusan National University)
  • 박재홍 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 이지연 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 여지영 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 남정수 (부산대학교 한의학전문대학원 양생기능의학부) ;
  • 정명호 (부산대학교 한의학전문대학원 양생기능의학부)
  • Received : 2011.04.14
  • Accepted : 2011.05.13
  • Published : 2011.07.30
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Abstract

Ginsenoside Rg1 is a pharmacologically active component isolated from ginseng. The goal of this study was to clarify the beneficial effects of Rg1 on glucose and lipid metabolism in diabetic animals (db/db mice). To accomplish this, ten week old db/db mice were administered 10 mg/kg of Rg1 for 15 days. Rg1 did not influence the weight of db/db mice when compared with vehicle-treated db/db mice. The administration of Rg1 lowered fasting plasma glucose, and improved glucose tolerance. Importantly, Rg1 markedly reduced both plasma triglyceride and free fatty acids, and increased high-density lipoprotein cholesterol (HDL-C) concentrations in db/db mice. Rg1 activated promoter activity of chimeric GAL4-PPAR${\alpha}$ reporter and increased expression of peroxisome proliferator-activated receptor alpha (PPAR${\alpha}$) target genes such as carnitine palmitoyltransferase-1 (CPT-1) and acyl-CoA oxidase (ACO), which are involved in fatty acid oxidation. These findings indicated that improvement of lipid profiles by Rg1 may be associated with increased fatty acid oxidation via PPAR${\alpha}$ activation. Taken together, these results suggest that Rg1 could have beneficial effects for controlling hyperglycemia and hyperlipidemia associated with type 2 diabetes.

Ginsenoside Rg1은 인삼에서 분리한 약물학적인 활성을 가지는 물질이다. 본 연구는 Rg1이 제2형 당뇨병 모델 동물에서 혈당과 지질대사에 유익한 효과를 가지는지를 확인하기 위한 목적으로 수행되었다. 10주령의 db/db 마우스에 Rg1을 10 mg/kg 농도로 15일간 경구투여한 결과 공복혈당이 감소하였고, 포도당 내성이 개선되었다. 특히 혈중 중성지방과 유리지방산이 유의적으로 감소하였고 혈중 HDL-콜레스테롤이 증가되었다. 또한 chimeric GAL4-PPAR${\alpha}$ receptor 활성 프로모터를 활성화시켰고 PPAR${\alpha}$ gene인 CPT-1 (carnitine palmitoyltransferase-1)과 ACO (acyl-CoA oxidase)의 발현을 증가시켰는데 이것으로 Rg1의 지질대사 개선이 PPAR${\alpha}$ 활성에 의한 지방산 산화에 의한 것임을 확인할 수 있었다. 모든 결과를 종합해 볼 때, Rg1은 제2형 당뇨병과 관련된 고혈당증과 고지혈증에 유용한 효과를 가짐을 확인하였다.

Keywords

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