• BMB Reports
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• 제51권2호
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• pp.73-78
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• 2018

Vascular endothelial growth factor and its receptor (VEGF-VEGFR) system play a critical role in the regulation of angiogenesis and lymphangiogenesis in vertebrates. Each of the VEGF has specific receptors, which it activates by binding to the extracellular domain of the receptors, and, thus, regulates the angiogenic balance in the early embryonic and adult stages. However, de-regulation of the VEGF-VEGFR implicates directly in various diseases, particularly cancer. Moreover, tumor growth needs a dedicated blood supply to provide oxygen and other essential nutrients. Tumor metastasis requires blood vessels to carry tumors to distant sites, where they can implant and begin the growth of secondary tumors. Thus, investigation of signaling systems related to the human disease, such as VEGF-VEGFR, will facilitate the development of treatments for such illnesses.

• 한국자원식물학회:학술대회논문집
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• 한국자원식물학회 2002년도 춘계 학술발표대회
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• pp.38-38
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• 2002

• IMMUNE NETWORK
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• 제13권3호
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• pp.102-106
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• 2013

Emerging evidence suggests that gap formation and opening of the endothelial junctions during leukocyte extravasation is actively controlled to maintain the integrity of the vascular barrier. While the role for endothelial cells to this process has been well defined, it is not clear whether leukocytes are also actively contributing to endothelial barrier function. We have recently showed that extravasating leukocytes deposit microparticles on the subendothelium during the late stages of extravasation, which is LFA-1 dependent. Using multiphotonintravital microscopy (MP-IVM) of mouse cremaster muscle vessels in the current work, we show that microparticle formation and deposition maintains the integrity of the microvascular barrier during leukocyte extravasation. Inhibition of neutrophil-derived microparticle formation resulted in dramatically increased vascular leakage. These findings suggest that deposition of microparticles during neutrophil extravasation is essential for maintaining endothelial barrier function and may result in temporal difference between neutrophil extravasation and an increase in vascular leakage.

• Journal of Plant Biology
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• 제29권2호
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• pp.129-133
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• 1986

Transections of the stem region close to the shoot apex show the occurrence of an outer, complete ring of procambium and an inner group of discrete procambial strands. From the outer ring, small, discrete vascular bundles and vascular cambium originate, while the inner group forms the discrete, medullary vascular bundles with intrafascicular cambium. Secondary thickening is essentially due to the activity of the cylinder or complete ring of vascular cambium that originates from the procambium. The medullary intrafascicular cambia also form some secondary tissues. The vascular cambium produces secondary xylem inwards and secondary phloem outwards as in the normal secondary thickening process. The distinctive feature, however, is perpetual discreteness of the medullary vascular bundles. No successive series of cambia or secondary vascular bundles are found.

• BMB Reports
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• 제54권11호
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• pp.569-574
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• 2021

Vascular calcification is the heterotopic accumulation of calcium phosphate salts in the vascular tissue and is highly correlated with increased cardiovascular morbidity and mortality. In this study, we found that the expression of neuromedin B (NMB) and NMB receptor is upregulated in phosphate-induced calcification of vascular smooth muscle cells (VSMCs). Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/β-catenin signaling and VSMC apoptosis. PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. The results of this study suggest that NMB-NMB receptor axis may have potential therapeutic value in the diagnosis and treatment of vascular calcification.

• BMB Reports
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• 제50권4호
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• pp.208-213
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• 2017

Vascular endothelial growth factor (VEGF) is an essential cytokine that has functions in the formation of new blood vessels and regression of cardiac hypertrophy. VEGF/VEGF-receptor-1 (VEGFR1) signaling plays a key role in the regression of cardiac hypertrophy, whereas VEGF/VEGFR2 signaling leads to cardiac hypertrophy. In this study, we identified the prohypertrophic role of miR-374 using neonatal rat ventricular myocytes (NRVMs). Our results showed that overexpression of miR-374 activated G protein-coupled receptor-mediated prohypertrophic pathways by the inhibition of VEGFR1-dependent regression pathways. Luciferase assays revealed that miR-374 could directly target the 3'-untranslated regions of VEGFR1 and cGMP-dependent protein kinase-1. Collectively, these findings demonstrated that miR-374 was a novel pro-hypertrophic microRNA functioning to suppress the VEGFR1-mediated regression pathway.

• 식물분류학회지
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• 제40권1호
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• pp.16-26
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• 2010

한국산 조팝나무속(Spiraea L.)에 속하는 3절 18분류군(sectts. Calospira: 복산방화서절 - 7분류군, Chamaedryon: 산방화서절 또는 산형화서절 - 10분류군, Spiraria: 원추화서절 - 1분류군)에 대해 엽병의 횡단면을 단부, 중앙부, 기부로 나누어서 비교하고 기재하였다. 엽병의 횡단면은 아원형, 렌즈형이거나 반달형이고, 두 개의 분리된 날개를 갖는 분류군과 날개를 갖지 않는 분류군으로 세 부위(단부, 중앙부, 기부)에서 차이를 보였다. 엽병의 해부학적 형질로는 횡단면의 모양 및 크기, 유관속의 모양 및 크기, 그리고 모용 및 결정체의 모양과 존재 여부들이 분류군 간에 비교 되었다. 본 연구 결과에서는 엽병의 해부학적 형질들이 한국산 조팝나무속내 분류체계에 적용시키기에는 미약하였지만, 종간 진단형질로는 유용함이 확인되었다. 엽병형질들을 바탕으로 한국산 조팝나무속 분류군에 대한 검색표를 제시하였다.

• 한국자원식물학회지
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• 제22권2호
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• pp.159-179
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• 2009

화천 일산에 대한 관속식물 분포와 용도를 파악하기 위하여 2008년 4월부터 10월까지 6회에 걸쳐 조사하였다. 그 결과 확인된 관속식물은 총 91과 295속 422종 1아종 58변종 15품종 등 총 496분류군이었다. 조사된 496종류 중에는 한국특산식물 17분류군, 희귀식물 9분류군과 멸종위기 식물인 백부자가 포함되어있다. 식물구계학적 특정식물종은 금강초롱꽃과 백부자를 포함하여 총 68분류군으로 나타났다. 귀화식물은 27분류군이었으며 귀화율은 5.4%, 도시화지수는 9.4%로 나타났다. 용도는 식용이 201종류(40.5%)로 가장 높게 나타났으며, 약용이 168종류(33.9%), 목초용이 69종류(13.9%), 관상용이 61종류(12.3%), 목재용이 17종류(3.4%), 섬유용이 16종류(3.2%), 그리고 공업용이 4종류(0.8%)로 나타났다.

• Genomics & Informatics
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• 제19권1호
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• pp.6.1-6.10
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• 2021

Vascular endothelial growth factor (VEGF) is expressed at elevated levels by most cancer cells, which can stimulate vascular endothelial cell growth, survival, proliferation as well as trigger angiogenesis modulated by VEGF and VEGFR (a tyrosine kinase receptor) signaling. The angiogenic effects of the VEGF family are thought to be primarily mediated through the interaction of VEGF with VEGFR-2. Targeting this signaling molecule and its receptor is a novel approach for blocking angiogenesis. In recent years virtual high throughput screening has emerged as a widely accepted powerful technique in the identification of novel and diverse leads. The high resolution X-ray structure of VEGF has paved the way to introduce new small molecular inhibitors by structure-based virtual screening. In this study using different alkaloid molecules as potential novel inhibitors of VEGF, we proposed three alkaloid candidates for inhibiting VEGF and VEGFR mediated angiogenesis. As these three alkaloid compounds exhibited high scoring functions, which also highlights their high binding ability, it is evident that these alkaloids can be taken to further drug development pipelines for use as novel lead compounds to design new and effective drugs against cancer.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 1999년도 정기총회 및 춘계 학술발표회
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• pp.29-29
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• 1999