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Korean Society for Biochemistry and Molecular Biology (생화학분자생물학회)
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Neuromedin B modulates phosphate-induced vascular calcification

  • Park, Hyun-Joo (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Kim, Mi-Kyoung (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Kim, Yeon (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Kim, Hyung Joon (Department of Oral Physiology, School of Dentistry, Pusan National University) ;
  • Bae, Soo-Kyung (Periodontal Disease Signaling Network Research Center (MRC), School of Dentistry, Pusan National University) ;
  • Bae, Moon-Kyoung (Department of Oral Physiology, School of Dentistry, Pusan National University)
  • Received : 2021.07.08
  • Accepted : 2021.10.06
  • Published : 2021.11.30
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Abstract

Vascular calcification is the heterotopic accumulation of calcium phosphate salts in the vascular tissue and is highly correlated with increased cardiovascular morbidity and mortality. In this study, we found that the expression of neuromedin B (NMB) and NMB receptor is upregulated in phosphate-induced calcification of vascular smooth muscle cells (VSMCs). Silencing of NMB or treatment with NMB receptor antagonist, PD168368, inhibited the phosphate-induced osteogenic differentiation of VSMCs by inhibiting Wnt/β-catenin signaling and VSMC apoptosis. PD168368 also attenuated the arterial calcification in cultured aortic rings and in a rat model of chronic kidney disease. The results of this study suggest that NMB-NMB receptor axis may have potential therapeutic value in the diagnosis and treatment of vascular calcification.

Keywords

Acknowledgement

This research was supported by the National Research Foundation of Korea grant, funded by the Korean government (MSIT) (NRF-2018R1A5A2023879) (to M-K Bae), and Basic Science Research Program through the National Research Foundation of Korea funded by the Ministry of Education (NRF-2019R1I1A1A01061 377) (to H-J Park).

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